moggy chicken log
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@sunsunsun lucky dog to have an owner like yourself
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As a change to the protocol I will be restricting electrolytes apart from sodium and calcium as well restricting fluid intake to like 2l a day. Let’s see. Travels were really good and Ray Peat blessed me, the only PUFA I was given and of course I accepted, was a slice of pizza with garlic mayo on it. It was good af lol
Why electrolytes restriction?
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@user1 intuition and historically in the west people weren’t pottasium and magnesium maxxing. They ate the RDA or below. They didn’t really even consume pottasium rich fruits. They drunk when thirsty. Not for hydration, boost performance etc. And personal experience, most importantly
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@sunsunsun maybe. Salt, insulin and euthyroidism promote its retention
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@user1 intuition and historically in the west people weren’t pottasium and magnesium maxxing. They ate the RDA or below. They didn’t really even consume pottasium rich fruits. And personal experience, most importantly
If you eat any whole food, non refined, for the most part it has potassium and magnesium, whever its fruits, tubers, animals foods. Do you get negative effects from these? If you eat a lot of these foods, it feel like. It can dilute your fluids and Lower your concentratioln of many things, including selenium, molybdenum, zinc, salt, specifically of. You don't i'gest the seeds and don't digest some part of it, so If The goal is to.mog, some nuts, underground foods, some.meat/fish(if you do.eat meat, ain't saying you should), whole milk Dairys, is optimal, you can notice that you might. Need the foods mention'ed above If you start feeling like Your feelings are not/less intense, you feel low/0 fertility even after an overnight fast, your dreams get dullers/darker in color, potentially slopper, and you get higher propency to negative emotions awake and during dreams
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@alfredoolivas do you have any theories about what's happening with excess mag and pot, and what's possible with their reduction?
I like Ray's kinda-theory that something being high or low somewhere in a traditional diet isn't a priori good, but that other nutrients or hormones compensate for their deficiency so it's effect is neutralized. the fat lady hasn't sung yet of course, so you may be on to something and I look forward to hearing
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@LetTheRedeemed I tried to type my thoughts last night but my reasoning, history and experiences are too long and jumbled and even biased. I’ll try this out and get back to you all, this Saturday
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@LetTheRedeemed I tried to type my thoughts last night but my reasoning, history and experiences are too long and jumbled and even biased. I’ll try this out and get back to you all, this Saturday
perhaps the Peatiest approach of all
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@LetTheRedeemed XD facts.
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week 14: 71.5kg down from 81.1kg, Salt and fluid restriction is definitely thermogenic. I can’t tell if appetite has changed.
Doing 12g of salt spread throughout the day. Weight jumped up to 72.2kg, mayhaps it’s coming down. I will keep on doing this. I scored high on Mensa denmark (121 IQ), so I think it’s a diet that supports cognition. That’s not even a flex btw, you read for my experiences, you get my experiences; the good and the bad
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wait, are you off GLP-1 ? if so why dont you use it?
secondly, nice work on the Mensa test
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@sunsunsun I’ve been off for a year? That’s news? Not even trying to make a joke lol, I would have mentioned that I was taking them on this thread. My motility is too slow already, so I would be at greater risk of gastoparesis, I am not hyperphagic and there are anti dopamine side effects.
Thanks
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My motility is too slow already, so I would be at greater risk of gastoparesis
Resolor 0.5 mg one hour before bedtime to optimize a lazy MMC.
If dysbiosis:
Erythromycin and rifaximin both have potential roles in addressing a "lazy" gastrointestinal migrating motor complex (MMC), but they work through different mechanisms. Erythromycin, a prokinetic agent, directly stimulates the MMC and gastric emptying. Rifaximin, a poorly absorbed antibiotic, can improve symptoms associated with MMC dysfunction, particularly in cases of small intestinal bacterial overgrowth (SIBO) and related conditions like IBS-D, by reducing methane production and modulating the gut microbiota. -
@LucH thanks boss. Resolor would work well, I take nicotine to have a bowel movement everyday and aparrently it works via serotonergic/ cholinergic mechanisms. does it stay local in the gut?
I did have 3 bowels movements on Monday. I was not taking aspirin and consumed pufa the day before. Do you think the lack of prostaglandins can cause constipation?
I don't think I have a gut overgrowth, my gut doesn't get bloated or I fart, it's just digestion is so slow sometimes...
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it's just digestion is so slow sometimes...
Yes, I understand: I see 2 possible problems:
- lack of enzymes when overloaded. When my digestion is lazzy I take one caps (enzymedica lipogold). + one stimulation at the evening for bile. Only when required.
- lazy MMC (interprandial digestion)
Targeting MMC dysfunction in lazy bowel syndrome
Resolor (prucalopride) is already a selective 5-HT₄ agonist — it is stimulating serotonin receptors, specifically the ones that drive propulsive motility and enhance MMC activity in the small bowel. So that box is already ticked, and ticked well.
Adding broader serotonergic stimulation won’t do the job.
Acetylcholine receptors
Well seen but not appropriate so. Why? Chasing acetylcholine receptors without fixing the MMC timing is like pressing the accelerator when the ignition isn't firing.
What actually targets the mechanism:
- Motilin rhythm re-education— fasting windows timed to allow full MMC cycles (ideally 90–120 min of genuine inter-meal fasting, no snacking). Best 180-240 minutes.
• Ghrelin axis — ghrelin is a potent motilin-receptor agonist and MMC driver; avoiding late meal (after 8 PM) protects the biological rhythms.
• Prucalopride at the right time is already the most mechanistically precise pharmacological lever available. The best one. I've used it to re-inialize a lazy transit with dysbiosis (+ essential oils, with a protocol)
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@LucH Gotcha thanks, please share the protocol if possible
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the protocol if possible
Yes, OK, but tomorrow.
Sth else: Adrenal stimulation
When I want to stimulate energy (within 2 hours after wake up), I massage the dorsal area where the adrenal glands are located with essential oil in a base (mainly black spruce essential oil, with Scots pine and andiroba) (épinette noire et pin sylvestre). Contraindication: hormone-like action (cancer). -
share the protocol if possible
For general purpose:
How to stimulate MMC (lazy interprandial movement)- Definition of MMC
- When using a prokinetic as standalone solution or a combo with an antibiotic and which one (erythromycin or rifaximin).
- How to use EO (dose and protocol)
*) The migrating motor complex (MMC)
MMC stands for migrating motor complex
MMC is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (= interprandial phase) (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic.
NB 1: I’ve used Resolor 0.5 mg, as prokinetic (1 tablet 1 mg cut into 2 pieces) which is classified as laxative but not used so).
NB2: When the gastro-intestinal problems last for more than 3 months, we have to suppose there is bacterial overgrowth or inappropriate colonic phyla in the second part of the colon. At his point, the need for antibiotic is required (medical assistance).
Rifaximin is the most commonly prescribed antibiotic for small intestinal bacterial overgrowth (SIBO) and is considered a good option for addressing lazy transit and bacterial overgrowth in the second part of the colon. Rifaximin is often the first-line treatment for SIBO, with studies showing eradication rates of up to 84% (with assistance of a healthcare professional).
NB: Erythromycin, as a prokinetic drug, accelerates gastric emptying in both healthy individuals with normal gastrointestinal function and in patients with critical gastroparesis
*) Which antibiotic
Erythromycin and rifaximin both have potential roles in addressing a "lazy" gastrointestinal migrating motor complex (MMC), but they work through different mechanisms. Erythromycin, a prokinetic agent, directly stimulates the MMC and gastric emptying. Rifaximin, a poorly absorbed antibiotic, can improve symptoms associated with MMC dysfunction, particularly in cases of small intestinal bacterial overgrowth (SIBO) and related conditions like IBS-D, by reducing methane production and modulating the gut microbiota.
Erythromicin Mechanism
Erythromycin acts as a motilin receptor agonist, stimulating the MMC and promoting gastric emptying. It induces premature MMCs at lower doses and can prolong their cycle length at higher doses.
Considerations: Erythromycin can cause side effects like diarrhea and nausea. It may also contribute to antibiotic resistance if used frequently.Rifaximin Mechanism:
Rifaximin is a non-absorbable antibiotic that primarily acts within the gastrointestinal tract. It can reduce bacterial overgrowth, including methane-producing bacteria, which can be a factor in slow transit constipation.
Considerations: Rifaximin has a favorable safety profile with minimal systemic absorption and fewer side effects compared to other antibiotics.Which to Choose?
The choice between erythromycin and rifaximin depends on the specific underlying cause of the "lazy" MMC and associated symptoms:
• If delayed gastric emptying is the primary issue:
Erythromycin is a good choice as a prokinetic agent to improve gastric motility and emptying.
• If SIBO, dysbiosis, or IBS-D are suspected or diagnosed:
Rifaximin is a good option to address bacterial overgrowth and related symptoms.
• In some cases, a combination of both might be considered:
For example, erythromycin could be used to improve gastric emptying, while rifaximin addresses SIBO.
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