moggy chicken log

LucH

@alfredoolivas said:

My motility is too slow already, so I would be at greater risk of gastoparesis

Resolor 0.5 mg one hour before bedtime to optimize a lazy MMC.
If dysbiosis:
Erythromycin and rifaximin both have potential roles in addressing a "lazy" gastrointestinal migrating motor complex (MMC), but they work through different mechanisms. Erythromycin, a prokinetic agent, directly stimulates the MMC and gastric emptying. Rifaximin, a poorly absorbed antibiotic, can improve symptoms associated with MMC dysfunction, particularly in cases of small intestinal bacterial overgrowth (SIBO) and related conditions like IBS-D, by reducing methane production and modulating the gut microbiota.

alfredoolivas

@LucH thanks boss. Resolor would work well, I take nicotine to have a bowel movement everyday and aparrently it works via serotonergic/ cholinergic mechanisms. does it stay local in the gut?

I did have 3 bowels movements on Monday. I was not taking aspirin and consumed pufa the day before. Do you think the lack of prostaglandins can cause constipation?

I don't think I have a gut overgrowth, my gut doesn't get bloated or I fart, it's just digestion is so slow sometimes...

LucH

@alfredoolivas said:

it's just digestion is so slow sometimes...

Yes, I understand: I see 2 possible problems:

lack of enzymes when overloaded. When my digestion is lazzy I take one caps (enzymedica lipogold). + one stimulation at the evening for bile. Only when required.
lazy MMC (interprandial digestion)
Targeting MMC dysfunction in lazy bowel syndrome
Resolor (prucalopride) is already a selective 5-HT₄ agonist — it is stimulating serotonin receptors, specifically the ones that drive propulsive motility and enhance MMC activity in the small bowel. So that box is already ticked, and ticked well.
Adding broader serotonergic stimulation won’t do the job.
Acetylcholine receptors
Well seen but not appropriate so. Why? Chasing acetylcholine receptors without fixing the MMC timing is like pressing the accelerator when the ignition isn't firing.
What actually targets the mechanism:

Motilin rhythm re-education— fasting windows timed to allow full MMC cycles (ideally 90–120 min of genuine inter-meal fasting, no snacking). Best 180-240 minutes.
• Ghrelin axis — ghrelin is a potent motilin-receptor agonist and MMC driver; avoiding late meal (after 8 PM) protects the biological rhythms.
• Prucalopride at the right time is already the most mechanistically precise pharmacological lever available. The best one. I've used it to re-inialize a lazy transit with dysbiosis (+ essential oils, with a protocol)