The Mysterious Case of Pufa Depletion
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@alfredoolivas so are you saying that if you cooked with pure stearic acid, you'd absorb only 15% of it? in other words, you get a free total fat reduction, or are you talking about absorption in the pure form?
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@engineer “I'm not a fan of consuming stearic acid from manufactured sources. "The efficiency with which human subjects digest stearoyl from cocoa butter still remains uncertain, while the digestion of total long-chain fat from this source is 0.89-0.95 g/g, high in comparison with 0.33 g/g for Salatrim 23CA and 0.15 g/g for tristearin in their prepared states." https://pubmed.ncbi.nlm.nih.gov/19087439/. According to this study, stearic acid in cocoa butter is 89-95% absorb-able, while staric acid from tristearin is 15% absorb-able. The fireinabottle stearic acid is mainly tristearin. The cocoa butter stearic acid is mainly stearoyl“
I remember this Reddit comment that’s all. Yeah.
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Alright I’m starting my journey to pufa depletion in a year. I crunched some numbers and, assuming my total pufa stores are around 35-45% of total fat weight, I figure I can get that down to 8% in a year.
It’s gonna consist of dropping my total body weight stores to about 10-11lb of total BW, or around 8-10% body fat, then purposely gaining weight with saturated fat, then dropping total body weight back down to 10-11lb.
Each time I drop my body weight my total pufa stores also go down in weight. Then Purposely adding fat mass to my frame will dilute the percentage of pufa stores. Rinse wash repeat.
I am Rays biggest Peater
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@alfredoolivas on the stearic acid issu i think I remember haidut citing studies and say ing it helped for himself but then later discovered he developed a tolerance-like thing for it, so it didn't work asmuch. I'll see if i can find those discussions
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@texugodomel you’re twitter got suspended? If you have a new account and would like shoutouts to regain your following let us know !
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I think I got your handle wrong mate, ignore me
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@texugodomel I've been thinking about what you've said on this thread.
Despite my attempt at a quick dilution, will my cellular lipid structure maintain the same 2-6 year half life of pufa?
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@hcwilliams
No. This is an estimate extrapolated from another situation and is based on removing only PUFAs from the diet while keeping everything else the same.
If you accelerate total weight loss, or accelerate it by other means, this “half-life rule” does not apply
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@TexugoDoMel wow, the human body has incredible adaptation
I wonder why, then, Ray expressed interest in personally supplementing with Dipalmitoylphosphatidylcholine (DPPC) and Distearoylphosphatidylcholine (DSPC) which help saturate lipid cardiolipin.
...Expressing interest far enough into his low pufa diet for it to have... negligible effects at best (?)
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@hcwilliams bro if you just ate extremely low fat and locked in with a calorie deficit, you would of dropped a percentage in LA bodyfat by now, just do it and stop overthinking. Don’t be lazy
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@alfredoolivas bro I’m just asking questions
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@hcwilliams
Ray recommended the slow approach.
-Remove PUFAs from the diet
-More carbs
-Antilipolytics (B3, aspirin, etc.)
-Other “saturators” (such as policosanol and perhaps the ones you mentioned)
-T3 supplementation(which has a PUFA-depleting effect when you've already limited them in your diet)That way, you limited the PUFAs’ access to the mitochondria and could safely eliminate them through glucuronidation.
The effect is the same as what I mentioned in one of my earlier comments. If a sample were taken, the tissues would have very low levels of PUFAs, so you could eliminate them in a controlled manner, which isn’t the case for most peaters, since losing fat isn’t really a concern for most of them. In that case, every time too much stored PUFAs were released, the situation would change.
If someone has the patience to wait 4–6 years for that, I don't see why they shouldn't plan for gradual weight loss as well. You can easily lose 10–20 kg over that time without even worrying about it. Peaters madness
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@alfredoolivas @texugodomel ive been digging thru some of yalls posts and twitter and it looks like im not the only one on this pufa depletion journey lol
can someone explain whats going on with this fella here^^? seems like he would be pretty saturated by now? is he on thyroid medication?
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fuck nvm he's high starch
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@hcwilliams how much weight have you lost
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@alfredoolivas 20lb including water weight
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@hcwilliams said:
Is there any supporting evidence for these claims? If by lipogensis you mean the creation of saturated fat from glucose then yes of course this can greatly help dilute stored PUFA, ray veven recommended this. But despite it, it still takes years to achieve dilution from what I understand . It’s also a small amount and not significant.
Lipogenesis is not creating "saturated fat from glucose." This is a massive misconception. Lipogenesis creates Palmitic Acid (which is a saturated fat) from Acetyl-CoA and Maylonyl-CoA (which itself is created from Acetyl-CoA). Those Acetyl groups can come from any energy source- glucose, fructose, Krebs cycle intermediates, alcohol, and (the big one) other fats. Studies frequently show that a high fat diet activates Fatty Acid Synthase more than lower fat diets. Many fats, especially PUFA and Omega 3 fats, undergo "carbon recycling," which is breaking down the fat into Acetyl groups, and then rebuilding them into safer fats like Palmitic Acid. FAS only creates palmitic acid, but there are other enzymes that can elongate and desaturate it.
A lower fat, high carb/sugar diet will use most of those carbs for energy, while circulating PUFA will be broken down into acetyl groups, and then rebuilt into palmitic acid. So, the process is much more direct, and not all PUFA will be burned as PUFA, some will be broken down and rebuilt into SFA, and some will be excreted.
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@ZackVegas thanks for that
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@hcwilliams amazing work
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@alfredoolivas thank the DNP
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