Unpleasant experience on thyroid
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@scamp You might need to use T4 too. Apparently many people have this reaction to T3 monotherapy, and there's a reason neither Ray Peat not any of the "thyroidologists" he cites has recommended it.
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I have neglected the temperature till now, because not much is happening here. My typical sleep-deprived morning temperature has risen somewhat, from pre-thyroid 96.1-96-3 to now 96.8-97. Interestingly, my afternoon temperatures have not increased at all, remaining at around 97.7 to 98. Once, when I could sleep somewhat well, I got a morning temperature of 98.1 or so.
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Some more observations:
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I have detailed dreams with coherent plots that I remember almost every night. Before thyroid I rarely dreamed and it never happened when I was sleep deprived. If only these weren't all nightmares it would be pretty cool;
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my spatial abilities seem to improve in leaps and bounds on their own. I've mentioned an improved driving ability before, but I haven't noticed just how much has changed. For example, before thyroid parking backwards was very difficult for me, because I had no ability to conceptualize what is going on where I couldn't directly see or to accurately estimate small distances. Now I do and it's like gaining a new sense. (Is this where the stereotype of women having a hard time with parallel parking etc. comes from?);
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I have a lot of new hair (baby hairs?) on my head, but it's all gray. I had some gray strands before as a reaction to stress, but now it's more uniform. It's not that noticeable yet, but if the trend continues I'm gonna look like I've dyed the edge of my hairline, leaving the rest my usual black.
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Today is the third day of taking 6 drops of Tyromax (7 are equal to a grain). This evening I've managed to clock a temperature of 98.2, the highest so far outside having a fever.
I feel hungry all the time for something unspecified - I eat eggs, cheese, apples, drink like a gallon of milk a day, dump white sugar down the drain, it's not enough even when I feel stuffed to the gills. I seem to crave starch specifically, I will try to introduce white rice again.
I also started taking niacin again. 250 mg dose has failed to produce a flush, so it seems I'm quite depleted.
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Okay, this came downhill fast.
Now I have 99 after eating and I don't feel good at all. I feel agitated My hands are still cold. My pulse is 80, so I assume I don't have any heart complications. I have also very frequent bowel movements. No other symptoms of hyperthyroidism.
What to do? Just abandon the whole experiment and hope my natural production is not permanently suppressed? Go back to the last dose (4 drops) in which I've felt good and stay on it until I have absolutely no stress symptoms? Ride it out? Add some more supplements (I have been wary of adding niacin to the mix, but maybe I actually need it)? Change the product? Do not attempt to supplement thyroid without dropping my general stress levels?
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@DonkeyDude the ratio of T4 to T3 should be at least 10:1, that’s what I’ve been reading.
Too much exogenous T3 lowers ft4 because it directly suppresses TSH, which in turn, halts your natural T4 production. And the exogenous T4 that you take is not enough.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821467/
So you either lower the T3 dose, or increase the T4 dose.
Add Levothyroxine on top of NDT. -
@GreekDemiGod T4 suppresses TSH, which is a good thing. I don't think TSH is in charge of T4 production. I think most people would agree a ratio of 3:1 or 4:1 for T4:T3 is fine (which is what I think is in Tyromax)
@DonkeyDude cortisol, adrenaline, prolactin, TSH are all stress mediators that are there for a reason. if you're trying to directly increase your metabolic rate without regard for what lowered it in the first place I'm not sure that's a good idea. I think you should lower the dosage to 4 drops and take pregnenolone to lower stress then just take it from there. no need to push for something that affects you adversely.
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@GreekDemiGod interesting. I'm not sure how I could get pure T4, though. Also, aren't most people supposed to do better on more T3? Didn't you start your recent thyroid treatment with equal doses of both?
@izkrov said in Unpleasant experience on thyroid:
if you're trying to directly increase your metabolic rate without regard for what lowered it in the first place I'm not sure that's a good idea.
I believe my metabolic rate was lowered by severe childhood stress combined with secondary malnutrition (constant stress messed up my digestion which lowered my appetite; also there was this weird power play at home related to food). I assumed that with proper nutrition and a more supportive social environment I might try and reverse that problem.
I'm much more calmer now; and after some thought I think it's because I had taurine with my (probably too strong as is) morning coffee. I didn't think of it before because I used to do megadoses of taurine with little effect (and it never did anything for my temps). For the time being I will lay off the taurine, lower my caffeine intake and stay with five drops for two more weeks. I will also look into what might be still missing in my nutrition.
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@DonkeyDude I wouldn’t abandon ship after one bad day. It takes time for the body to adjust. A bad week yea probably lower the dose till u get your temps back to how u want them. 99 isn’t too high really
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@DonkeyDude I switched to a higher ratio.
I’ve been reading how people who take NDT or high doses of T3 have the following pattern on a blood test: suppressed TSH from The exogenous T3, high ft3, and low ft4 due to the high exogenous T3 that s down-regulating the natural production. That’s when it clicked for me.
T3 comes with possible side effects and palpitations. T4 has a true therapeutic long-lasting effects.
Even Ray has said that 1-2 mcg is the highest T3 dose one should take per 2 hours.My blood tests from yesterday showed the same pattern on 1:1 ratio of T4 to T3.
Lowered TSH
Increased ft3
Lowered ft4.I switched to a higher ratio about a week ago.
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@GreekDemiGod I'm getting a thyroid panel soon, I'll see if my results match yours. What you say contradicts Peat, but fits Kenneth Blanchard's thyroid book I've recently read, are you familiar with it?
@BroJonas yeah, my temps are back and I'm calmer now. What freaked me out was the quick increase from sub-98 to 99. Now I think it's endotoxin related; I have bloating and stomach problems. I hoped that my gut issues would be solved by thyroid, but apparently not, or not yet. Niacin and S. Boulardii helped, and now my temperatures are back where they were before. I have to figure out a way to eat enough carbs without irritating my intestines: white sugar is mostly out, bananas are out, white rice probably too. I will also start eating liver more regularly to cover possible deficiencies.
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So I got a blood test today. I didn't get a full thyroid panel due to the cost.
My results are as below:
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Total cholesterol: 183 mg/dl. Before starting thyroid it was 180, and Ray said for someone on thyroid even 160 is acceptable, so I'm good here;
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Ferritin: 32.8 μg/l. I test that because one time I did get a result in the low teens and adding more iron helped somewhat. I need to eat liver more regularly, I felt better when it was around 50.
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Vitamin D (25-OH): 22.8 ng/ml. This is what I get for being a cheapskate. When starting thyroid I reasoned that the test is expensive, and I already had a vit D supplement on hand, so I assumed taking 2000 IU daily will be enough to avoid this problem. Today I took 10 000 IU and there's already some improvement in my mood; I assume this might be the main reason for my recent difficulties;
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TSH: 2.2 μU/mL. So I'm definitely not experiencing a thyroid storm and my TSH is not being suppressed by excess T3. However, this is puzzling because my TSH was actually lower (1.2) before starting NDT.
Does anyone know why taking thyroid might increase someone's TSH? Is it because exogenous hormones have suppressed my natural production, but due to vitamin D deficiency (or some other deficiencies) it fails to increase metabolism and thus the pituitary signals for even more? Or maybe my TSH was suppressed by cortisol (after all, 1.2 is kind of low for someone with waking temperatures in the low 97s), the NDT has lowered cortisol, so now TSH can reach its natural level? Or maybe NDT just isn't for me and I need more T3?
My plan for now is to eat liver at least once and preferably twice a week, blast Vitamin D like there's no tomorrow, and stay on the five drop dose until the worst issues go away.
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