Dexamphetamine withdrawal
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My husband is trying to come off or drastically reduce his dose of dexamphetamine. He was taking 45 x 5mg tablets a day for the past 3 months. Before that he was taking 27 x 5mg tablets a day for at least 4 years (some reductions in dose in between and up and down slightly at that dose).
7 days ago he quit cold turkey. He couldn’t function, was aggressive, agitated, depressed - catatonic at times, unable to get out of bed with exhaustion but could not sleep a lot.
Yesterday I have him 15 tablets as he was in so much pain and suffering.
He started this medication for fatigue more than add. Said he felt fatigued from age 10. This was around the time a family trauma started with a very ill family member that almost died many times then did die years later. His mum was on ssris whilst pregnant and for years before conceiving him.
During this withdrawal he has tried famotidine, ondansetron, heaps of aspirin. Nothing really helped.
He is hesitant to try mirtazipine because of past bad experience (anger). Bad reaction to clonidine (I’m thinking because he uses the medication for severe fatigue clonidine would have made that worse). I do think he should try even 3mg mirtazipine tonight to see if it helps withdrawal but again fatigue is a worry.
I just read an article in here mentioning some amino acids but I think the issue is really poor energy metabolism related to excess serotonin.
He is on slow release t3, 5mg twice a day. Says ndt makes him feel a bit weird (but I mean 45 dex a day could make anything feel weird)
Temp 36.14 on waking pulse 80. He eats bioenergetic style and gets 3500 calories a day.
We have bromocriptine on order and I’ll try get lisuride too
I’m wondering if anyone has any experience with this and what we might be missing
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@LucyJ As a last resort, low dosing LSD for a month may be helpful.
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Hi
I went through this
The only thing that got life moving again for me was high quality animal organs, dairy, fruit etc,,, Just the best quality food but mainly beef/lamb organs
Vitamin B3 helped me too, along with salt
If there is severe fatigue its the body screaming 'let me rest' or 'give me good food'
I would try epsom salt baths or soaking your feet, this can help relax the body if its been tense for a long time and helped me sleep
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The best way to reset stimulant tolerance is through NMDA antagonism.
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I think he actually has idiopathic hypersomnia and I was looking into this. I am going to find a source and try this I really think it will sort out the withdrawal and the actual problem thank you
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So lsd does this? And amantadine? Or is there something better?
I really appreciate this advice!! It makes so much sense
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@questforhealth
He’s eating well but I will try add b3 and baths. I think he’s said b3 makes him feel weird previously but thank you I will try -
@Appa
Can this be taken whilst stimulants are still being taken? Or can eg lisuride be used at the same time as stimulants are being tapered as he’s getting withdrawals as he drops the dose. The fatigue is really bad.I’m worried I’m going to cause serotonin syndrome but I can’t find much info that seems accurate on what actually happens
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@questforhealth
What b3 did you take? I think he has low brain histamine causing hypersomnia and reliance on dex and b3 could help this. Well the nicotinic acid version (which peat says don’t use) seems like it would help low histamine people? -
thats the one I used yeah
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@Appa said in Dexamphetamine withdrawal:
The best way to reset stimulant tolerance is through NMDA antagonism.
Magnesium is an NMDA antagonist.
An epsom salt foot bath or Mg supplement can work.
Amantadine is a powerful NMDA antagonist as well as having multiple other properties (inc dopamine "receptor activation" at D2).NMDA antagonists can "take the edge off" excitotoxicity and help to reset neurotransmitter patterns/systems aka habits.
