@ThinPicking no I haven't. I salt food to taste but don't eat enough calories so probably worth trying more. I will give it a shit thank you

@CrumblingCookie
I could try NAC again. I have it in my supplement graveyard.
Currently my glutamate issue has been made worse by progest e and p5p (10mg) which doesn’t make sense to me as they should help but the insomnia is the worst it’s been in years. I am almosy scared of all supplements currently. B3 really sets me off shaking at 50mg (niacinamide) but I could try low dose b2 again.

Wonder if Amantadine or memantadine would be worth a try or even micro dosing ketamine to try stop whatever is currently going on?

Does anyone know where I could get this? I live in Australia and it doesn't seem to be easily accessed.

I have a major glutamate anxiety issue and want to try this to see if it helps...

@Jonk Yep that's actually the book that got me to start taking it given my history with bronchitis and explained a lot of my childhood issues. I should potentially re read it. I feel like I need more of it (armour) but then freak out its too much T4...
Thanks for sending that supp through, I will have a look

@cs3000 Yeah been running on adrenaline since I can remember. Very stressful childhood and excessive exercise and severely underweight. I eat salt to taste but could try measuring it out and making sure I am getting 5g.

I haven't tried methylfoate for 2 years but it was one of the worst histamine gut reactions I got. I was taking bioceutical MTHF. I think I read if you were deficient in other b vitamins then you could have histamine response from folate. I'm better with consuming liver which you've reminded me to do.

I wish I could take tudca on an empty stomach! My upper gi is so sensitive and I feel a lot of adrenaline comes from my stomach and small intestine being irritated. Hence famotidine helping so much. So you take tudca before you eat each day?

@Jonk which multi do you take? I have pretty bad reactions to most supps. I think you replied to me on the old RPF suggesting a b vitamin but yeah everytime I try them I seem to get anxiety.(probably because they irritate my super sensitive upper GI) I'm really trying to find a way to commit to cronometer and meal plan as my goals for this year. So will start with one day and see how I go. Thank you

@cs3000 Thank you. Yes I do think lack of calories and getting enough protein is a big part.

I have this huge resistance to use chronometer, not entirely sure why. I really struggle to stick with it (out of character for me).

I do handle dextrose so I could get some. I stick to fruit juice for most of my carbs as you might have read I really struggle with fibre and starch still.

Truthfully I'm really co-ordinated and I've never had seizures.

I think the antibiotics is the die off releasing histamine that makes me crash. I wake up feeling hungover and woozy.

Surprisingly the armour makes me feel calm but I could try that.

The fatigue isn't normal fatigue (when I crash). Its like I'm hyper running around doing all my tasks and then wham it hits me and I cannot move, I have to fall asleep straight away. Maybe it's my liver.

Another thing is my teeth chatter constantly and I react very badly to clonidine and benadryl with hyped adrenaline surges and I can't sleep after taking them!? I have also decided today that ketotifen makes me worse re asthma/ breathing so I'm stopping it as swear it's increasing histamine (I only started it 1.5 weeks ago)

@cs3000 Just remembered I get hives from sun exposure on my chest so yeh maybe is actual MCAS

@cs3000
So I have a history of eczema and my thumb is often still itchy and scalp but I'm not a hives MCAS. I'm anxiety and hyper and fatigue and crash, poor appetite, reflux, POTS, hypermobility and severe nausea, breathing difficulties. I get skin sensory issues and can't handle wet hair and wetsuit but not hives.

I'm working to try and get more calories in but the poor appetite sucks for this. Even periactin doesn't seem to increase my appetite. I react to most supplements so don't take anything regularly. I have been recommended vitamin d and k2. If I take antibiotics and I don't take famotidine with it, I crash 2 hours post and sleep for 3 hours. If I take famotidine this doesn't happen. So maybe its just severe histamine in my gut and sibo not classic MCAS

Not so much uncoordintation but more shaking so bad it's had to balance and muscles almost collapsing. Often I can get through something but I'm shaking and feel very weak and dizzy after.

Any ideas for increasing appetite and calories welcome!

So pretty sure I have MCAS amongst a few other things maybe linked to RCCX gene. I'm not typical MCAS but crash asleep reactions and cervical instability/hypermobility and mild pots. I have quite bad shakiness and muscle weakness.

Famotidine helps as does cypro and ketotifen but not with the muscle weakness and shaking. They help with reflux and insomnia and anxiety.

Has anyone delt with MCAS and managed to reduce a lot of their symptoms? The cervical issue is mostly only a problem if I exercise. Exercise really sets me off but I so want to move and dance even though I feel like fainting quite often after class.

I take 1 grain of armour a day but do wonder if I should just take t3...

@Corngold thanks for this info. I just had a look, seems hard to get bufferin where I am and a few nasty ingredient but figure I could make my own version with quick eze and small dose aspirin and see if that helps