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    hirsutism from progest-e

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    • P
      peaty runescape
      last edited by

      So my girlfriend had painful period cramps and was had pms lately, so I gave her progest-e.

      every time after taking it she had a headache so she stopped after 7 days (3-4 drops dermally).

      She then noticed that her moustache is starting to grow. She also had period for 20 days. then it luckily stopped and stabilised.

      Does someone have any suggestion, how to help her with her hirsutism?

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      • S
        StrongestPeater @peaty runescape
        last edited by

        @tehpro I saw something about needing to fix thyroid before hopping on progest-e... and I would say I agree with it..

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        • P
          peaty runescape @StrongestPeater
          last edited by

          @StrongestPeater I heard that too, so testing thyroid levels would be a good start? I won't give her any thyroid meds on my own, as I am not really good at that(I made mess for her when I gave her progest-e). If she get's potentionally diagnosed for hypothyroidism, are the meds that doctor gives you ok?

          she always has icy feet (but she ain't dming anyone) and hands.

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          • S
            StrongestPeater @peaty runescape
            last edited by

            @peaty-runescape I am not well read enough to answer but I think you need to lurk on peaty twitter more. Meds that doctor gives most likely wont be good from what I have read...

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            • KvotheK
              Kvothe
              last edited by

              Progesterone doesn't cause hirsutism, there is no mechanism ever mentioned. Besides, a dose of 3-4 drops on the skin will barely affect circulating progesterone levels in the body. So, it makes no sense to assume that the progesterone is responsible for a sudden occurence of hirsutism. Vellus hair transformation into terminal hair is mostly due to the effect of androgens. Something that suddenly lowered her SHBG and significantly increased free androgens could be responsible.

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              • P
                peaty runescape @Kvothe
                last edited by

                @Kvothe said in hirsutism from progest-e:

                Progesterone doesn't cause hirsutism, there is no mechanism ever mentioned. Besides, a dose of 3-4 drops on the skin will barely affect circulating progesterone levels in the body. So, it makes no sense to assume that the progesterone is responsible for a sudden occurence of hirsutism. Vellus hair transformation into terminal hair is mostly due to the effect of androgens. Something that suddenly lowered her SHBG and significantly increased free androgens could be responsible.

                Reply

                Dear kingkiller, it surely caused a hormonal inbalance since it caused instant headaches everytime (so it had a strong effect), and she had a 3 week long period after that.
                She never had period lasting more than a week before. So everything points to progest-e, as she did not make any other changes.

                But it is true that her hirsutism might not be connected to that - as she had some hair falling out after stopping birth control half a year ago, maybe that could have caused it?

                KvotheK 1 Reply Last reply Reply Quote 0
                • KvotheK
                  Kvothe @peaty runescape
                  last edited by

                  @peaty-runescape Where did she apply the mixture?

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                  • P
                    peaty runescape @Kvothe
                    last edited by

                    @Kvothe to the stomach or navel, as it helped her period cramps.

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                    • izkrovI
                      izkrov
                      last edited by

                      I remember vaguely, from reading twitter that a lot of women that started progest-e initially had bad effects. One girl took 2 drops orally and felt like shit, dropped it for awhile but when she picked it back up and took 5 drops a day, it really helped her period pain.
                      I'm just speculating here, but what's probably happening is progest-e is releasing stored tissue estrogen and it's circulating throughout the system, causing headaches. I think for her hirsutism, androgens rose in order to be protective against the circulating estrogen.

                      On the RPF the way they suggested to counteract this was to take a megadose, like 200mg for the first time. My own idea would be to first take thyroid and ensure the liver's efficient so you can detox estrogen, and then do the megadose. If men take a large enough dose their whiskers stop growing, so for her hopefully the megadose would oppose androgens enough that it helps with the hirsutism.
                      Just throwing ideas out there.

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                      • C
                        CatlikeLantern @peaty runescape
                        last edited by

                        @peaty-runescape bro, message me. I have plenty of info and advice as my wife went through this exact thing.

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                        • N
                          nicgabhann @CatlikeLantern
                          last edited by

                          @CatlikeLantern Hi there, can I also message you?

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                          • B
                            BroJonas
                            last edited by

                            Ray kinda denied that Progest E could have any adverse effects as long as they took enough of it. And a mega dose at first might be needed. On the progest e site it says those with pcos may just turn small amount of Progesterone into estrogen so a big dose is needed at first.

                            But PCOS is driven by low thyroid and high adrenal activity so shifting that with extra thyroid supplementation should be more effective while Progest E will kinda temporarily patch symptoms, but is still very therapeutic

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                            • C
                              CatlikeLantern @nicgabhann
                              last edited by

                              @nicgabhann sure thing!

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