Dry eye disorder is often caused by androgen deficiency (restored by increasing testosterone)

cs3000

Androgens play a major role in keeping healthy eye & skin moisture

e.g dry eye disorder is common post menopause when hormones drop

replacing hormones post menopause restores skin moisture , but
https://pubmed.ncbi.nlm.nih.gov/11451620/

replacing estrogen post menopause isnt effective for helping dry eye disorder and can even worsen it ([Sex Hormones and Their Effects on Ocular Disorders and Pathophysiology: Current Aspects and Our Experience]
"The role of estrogen is not yet fully understood, but several in vitro animal and human studies show that estrogens decrease the secretion of the sebaceous glands, inhibit lipogenesis, and promote inflammation of the ocular surface"(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8949880/))

Higher E2 and lower luteinizing hormone (LH) were associated with worsening of dry eye symptoms (ρ = 0.34 p = 0.03, ρ = −0.49 p = 0.001). Reduction in LH and increase in progesterone (P4) were associated with increased ocular pain (ρ = 0.45, p = 0.004 and ρ = 0.39, p = 0.01). Dry eye symptoms were predicted by LH and tear break up

, even though low estrogen is correlated with dry eye disorder.
correlation exists as testosterone levels also drop in menopause, and the low estrogen is a sign of low testosterone too

Sometimes progesterone helps probably by countering estrogens effects, so combo may be best
https://iovs.arvojournals.org/article.aspx?articleid=2382585

&

On a clinical level, in fact, there is an alteration in the functioning of the meibomian glands and an increase in the risk of DED in all cases in which there is a reduction in circulating androgens, a dysfunction or insensitivity of the androgen receptors, or anti-androgen therapy
Meibomian glands provide key components to the tear film that help maintain a healthy ocular surface. When meibomian glands function correctly, the lipids secreted reduce ocular surface water evaporation and prevent dry eye

some men get vision problems paired with dry eyes and skin issues as they get older and its largely because of this testosterone/androgen drop (in both genders)
Age-Related Changes in Male Skin: Quantitative Evaluation of One Hundred and Fifty Male Subjects especially with skin issues on the neck or face. insomnia also

so in many cases the cure is replacing the lacking androgens / fixing the lack. e.g Hypothyroidism might also play a role here, as enough thyroid hormone needed to stimulate STaR protein for testosterone synthesis

Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women - PubMed
(testosterone mainly, in this study the estrogen likely wasnt necessary) "Ten (91%) of 11 patients reported improvement in dry eye symptoms while receiving treatment. For these 10, relief occurred after an average of 4.1 months of treatment (SD 3.2, range, 1-9 months)."

on the other side, in some cases tipping over to androgen excess can cause a blockage. something to be aware of, if taking high amounts and trying to fix eye issues which should only need a return to normal levels
https://www.nature.com/articles/6701905
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1857578/

izkrov

@cs3000 said in Dry eye disorder is often caused by hormone deficiency (restored by increasing testosterone):

because testosterone levels also drop in menopause, and the low estrogen is a sign of low testosterone

You have a preconceived notion and you're using some random combination of words to prove it. Low estrogen is a sign of low testosterone? I better go drink some soylent for some larger gains then. Genuinely retarded.

even though low estrogen is connected to dry eye disorder

Women are high in estrogen in menopause, this is completely wrong.
A quick example to disprove this would be that St. John's Wort is highly unsaturated (and therefore estrogenic) and it causes retina damage. Many people report some kind of sensitivity to light and dry eyes. Progesterone opposes estrogen and fixes that issue. Source: me after I took progest-e. Ray even wrote about this:

The popular supplements melatonin, tryptophan, fish oils, St. John's wort, and the various omega -3 oils, all increase the risk of retinal light damage and macular degeneration. Serotonin uptake inhibiting antidepressants are suspected to be able to cause it.

https://raypeat.com/articles/articles/aging-eyes.shtml

This really isn't so simple as just low T. Why don't you go on raypeat.com and actually read some of the articles first

Crypt Keeper

My eyes run like crazy when I go outside in the cold, especially if it's windy. The Internet (which is never wrong) says this is a dry eye issue. All this time I thought it was caused by low estrogen.