Glucose loading cures everything?
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@gentlepotato said in Glucose loading cures everything?:
I just got a new bag of glucose, same brand, but it smells more perfumed. I don't use any kind of perfumed products so for me it's very strong, and the smell reminds me of perfumed soap. There's a similar aftertaste, but other than that I feel the same having it. Has anyone experienced this? I found some mentions of it when I googled, but I'm not sure it was pure glucose or other sweeteners.
I bought a 50 lb bag of dextrose but it had a strange odor so didn't use it. I've had better luck with a couple of the brands in plastic containers, so I'm sticking with those.
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Nutricost is what I am using now, and it’s great. No odor at all.
My progress so far: I’m up to 30g X 4. Gained a few pounds which I’ll try to lose today and tomorrow, that has more to do with other factors I think. My temps are not really any different. I no longer have any stomach issue when I take my glucose.
I went on a fast walk up and down hills and when I returned my temps were really low, indicating a hypoglycemic episode. I’m sleeping well as usual.
I am feeling better than I usually do right now so far, fewer endotoxin symptoms, so that could be a good sign.
I’m just going to continue and see what happens.
My theory as to why this works:
I think this forces the body into sugar burning mode.
The lipolysis retreats. Ultimately you retrain your body to becoming a young sugar burner, which has many benefits in terms of raising CO2 levels and free radicals (protecting against cancer).
I think Dr. Stephens’ brain theory is sorta wrong, but they do call dementia type 3 diabetes. I think this dextrose works because without the fructose, it can efficiently stop excessive lipolysis and kickstart oxphos.
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@gentlepotato said in Glucose loading cures everything?:
it's very strong, and the smell reminds me of perfumed soap. There's a similar aftertaste
I had experienced and reported something similar already. You can try to keep the bag wide open for a few days (and put it into other containers) and see if some of those solvents dissipate. Some of them will. But as you can even taste them it's likely some (or all) will remain.
+1 on S.Holme's suggestion of not buying dextrose in cardboard boxes or paper bags anymore. (As also for many other foods' packagings, indeed) -
Thanks for your reports coming in, everyone.
@Ecstatic_Hamster said in Glucose loading cures everything?:
I think Dr. Stephens’ brain theory is sorta wrong, but they do call dementia type 3 diabetes. I think this dextrose works because without the fructose, it can efficiently stop excessive lipolysis and kickstart oxphos.
I also reckon that ultimately a lot is going to be mediated through liver energy metabolism. Which, not least through biliary functioning, duodenal microbiome and barrier integrity and non-translocation of pathogens, toxins and LPS, is directly related to brain inflammation and functioning.
This brief little comment also stuck with me and I am now looking into extra CoQ10 and (tauro)ursodeoxycholicacid:
@LetTheRedeemed said in "Glucose Loading" protocol, a la Dr Stephens - A Critique:
Honestly, if one's liver function is so compromised they need to avoid fructose, [...]
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@CrumblingCookie said in Glucose loading cures everything?:
Thanks for your reports coming in, everyone.
@Ecstatic_Hamster said in Glucose loading cures everything?:
I think Dr. Stephens’ brain theory is sorta wrong, but they do call dementia type 3 diabetes. I think this dextrose works because without the fructose, it can efficiently stop excessive lipolysis and kickstart oxphos.
I also reckon that ultimately a lot is going to be mediated through liver energy metabolism. Which, not least through biliary functioning, duodenal microbiome and barrier integrity and non-translocation of pathogens, toxins and LPS, is directly related to brain inflammation and functioning.
This brief little comment also stuck with me and I am now looking into extra CoQ10 and (tauro)ursodeoxycholicacid:
@LetTheRedeemed said in "Glucose Loading" protocol, a la Dr Stephens - A Critique:
Honestly, if one's liver function is so compromised they need to avoid fructose, [...]
I wonder if the fructose (in fruit and sucrose) is why so many gain weight when they begin following Dr. Peat. I did.
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Thanks for the input about the glucose! It's in a plastic bag, and there's a noticeable difference between the two bags I got, where one smells way more. But I'll try to air them out and see what happens!
@Ecstatic_Hamster Thanks for sharing! I didn't know the names of the pathways, and had not had capacity to read up on it yet, but I've been thinking along the same lines. I don't remember if I already mentioned this, but I wonder if the liver will accumulate fat if it is prioritizing those pathways, since fat has more energy per gram, and as a side effect would not store as much glucose, which could exasperate the problem. I had a blood test show higher triglycerides (after the week I did high sucrose, before my glucose arrived) and I was thinking it was because the liver was releasing fat and making space for glycogen. I seem to have more glycogen stored now.
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I like Dr. Mercola's gut healing protocol using glucose (I'm not using sucrose).
https://articles.mercola.com/sites/articles/archive/2024/09/15/the-truth-about-health.aspx
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How's everyone's sleep and anxiety level? I've just switched back to 1 tbsp every hour, after doing a few weeks of 3x4 + 1. Now I'm suspecting the higher doses caused a BG spike (it did when I tried a bigger dose, while I was wearing a continuous glucose monitor), and therefore consecutive rapid fall or even crashes, during the night especially.
I think I've had the worst sleep I can remember having for years, incredibly anxious and wildly sensitive to sound. I didn't realize it could be the change in doses, because my building experienced two very unusual and activating events (that turned out to be nothing) at night during the week and a half before I switched. What I've thought of as anxiety in the past has practically always turned out to be low blood sugar, but these unusual events made me think this time it could be anxiety. So it took me a while to see the possible connection, but yesterday I switched back. And last night my hearing was normal, I couldn't "make" myself anxious even when I tried and I slept well again.
Now I'm even more curious about how low cortisol affects blood sugar regulation, and whether adrenaline takes over cortisol's job - and if adrenaline can be activated by just blood sugar falling, even if it's not low. If anyone has done any research about this let me know.
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This is a very interesting thread.
I am about halfway through the High Calorie Malnutrition book, and it seems to me that doing this sort of sugar therapy will require large doses of thiamine to keep your levels up. A b-complex is also good and necessary, but thiamine will be easily depleted on this sort of program, as I understand it.
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@idealabsrat That's interstiting - high dose B1 thiamine is one approach in the ME/CFS world. Some people get much better from it, but it's a whole protocol and can be very expensive, and I found the protocol confusing. I think it's based on the idea that there is a low level of pyruvate dehydrogenase, and B1 is needed to create that - but from what I understand the low level of PDH is a former theory to the Itaconate Shunt hypothesis.
What is the thinking behind high B1 thiamine in the approach you mention? Can you share details?
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I have been reading here for some time, and just registered to write here. I've had dextrose as my main source of energy for 2,5 years, because I don't tolerate enough of any other carbs.
This summer I learned about the dextrose protocol and tried it. I got terrible blood sugar crashes.
Now I have found what works for me. I take one Tbsp at a time, and then I wait a few minutes before I take another Tbsp. Lately I've been taking 7 Tbsp during 30 minutes 3 times a day, before breakfast, lunch and dinner. I don't get blood sugar crashes now. -
@gentlepotato basically, thiamine deficiency is almost as prevalent as hypothyroidism, in the two are very much intertwined.
It's an enzyme transporter, responsible for multiple parts of the ETC, and whole host of things. It's very easily depleted by oxphos, and by metabolizing alcohol.
Thiamine is actually very cheap if you buy powder and put it in capsules. I use benfotiamine. At first I took a couple grams a day, and it took a week before it started to excrete in the urine.
Incidentally, high dose thiamine cured my "seasonal allergies" where I would wake up every day congested or only able to breath through one nostril.
@takethiamine on X has detailed threads about B1maxxing.
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Thanks for all the info, and I'll check out the profile.
@idealabsrat said in Glucose loading cures everything?:
At first I took a couple grams a day, and it took a week before it started to excrete in the urine.
What does that mean? Is that good or bad, and how do you know that's happening?
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@gentlepotato I was referring to just HOW deficient I was.
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@Lena that’s interesting, actually. Thank you.
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@Lena said in Glucose loading cures everything?:
I have been reading here for some time, and just registered to write here. I've had dextrose as my main source of energy for 2,5 years, because I don't tolerate enough of any other carbs.
This summer I learned about the dextrose protocol and tried it. I got terrible blood sugar crashes.
Now I have found what works for me. I take one Tbsp at a time, and then I wait a few minutes before I take another Tbsp. Lately I've been taking 7 Tbsp during 30 minutes 3 times a day, before breakfast, lunch and dinner. I don't get blood sugar crashes now.Thanks @Lena for sharing. That's so interesting.
As someone who has also experienced extreme blood sugar crashes on the glucose protocol, I'm curious to know more:- when you say you take 1 tablespoon at a time, I'm assuming you dissolve in water? I'm curious how much water/liquid per tablespoon?
- sorry for being pedantic, what is a "few" minutes, between tablespoons?
- what does your meals consist of? Macros and food types?
- has the volume of food changed on the dextrose protocol? I have found if I don't eat enough food with the Dextrose I experience hypo glycaemia.
- do you mind sharing age. I'm assuming you're female?
Thanks in advance!
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@idealabsrat thank you!
I'm going to try to check out thiamine.
I'm wondering how one determines that thiamine is being excreted in urine?
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@idealabsrat thanks for clarifying! Where do you buy the thiamine powder? Can you recommend a brand?
@marmalade_cat said
I'm wondering how one determines that thiamine is being excreted in urine?
Me too, wasn't able to find anything on this when I searched.
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@marmalade_cat said:
I'm wondering how one determines that thiamine is being excreted in urine?
I guess because thiamin has a very distinctive taste and smell?
The intramuscular route can be also dirt-cheap with 5-10 weeks of thiamin vials, syringes, needles, alcohol wipes going for $30, tops. What's really pricey is the oral benfothiamin form (or the Allithiamin/TTFD - glutathion needed to tackle the mercaptan group of this form).
But those forms are not neccessary as the same effects can be achieved by using four to five times as much ordinary Thiamin-HCl and every 5h in order to maintain maximum levels. There had been a global backlog for thiamin powder in recent years with really difficult availability. Don't know how that is going currently. I expect bulkpowders would carry thiamin-HCl in their store.
It's well worth looking into, imo. -
I’ve read through a copy of Dr David Stephens book recently And he suggested people land on a dose Between 40-80 Grams, 3 to 4 times a day, So between 160 and 320 grams Per day As a minimum and it can go much higher. This made me realise if I was going to do this I needed to vastly increase the amount of glucose I was taking each day.
I was trying to work out what feeling was aiming for when I knew I was at the correct dose. I’ve been exerting myself quite hard today, which caused my trigger happy adrenaline to start up with all the usual feelings of palpitations, but as per usual after I had finished exerting myself I got this 30 minutes of well-being and feeling really good. I thought, of course! This is the amount of glucose I need, I need the same amount of glucose as what my adrenaline produces in these moments of stress to start the feelings of well-being and ultimately endorphins. Although helpful, it also doesn’t make any sense for my glucose consumption to be Exactly the same amount throughout the day. It’s better to take glucose consistently throughout the day than not, but it feels ideally the amount of glucose should respond to the need of stressors and feeling To match the supply and demand. I’ve ended up dissolving 240 g of dextrose in a litre of milk to buffer it with the slightly. I keep it in a flask with me throughout the day and I’m going to try to intuitively drink the glucose in response to the stresses of the day. I think it’s may be worth upping the amount in the flask too!
Ultimately, I am hoping that this will achieve the affect that Dr David Stevens sees, with my brain cells becoming less resistant to glucose, Due to the lower levels of adrenaline needed, and therefore less lipolysis.
Also trying to combine thiamine, and co2 to create a virtuous spiral But early days with this!