Glucose loading cures everything?
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@Ecstatic_Hamster said:
that is a huge dose of folate.
Mind-bogglingly huge!
From what I could read, neuropsychiatric improvements from restoring cerebral folate sufficiency is a veeeeeery slow and a gradual process.
In other cases where 15mg folic acid daily was used, improvements only became evident 9 months later. With further, significant improvements 18 months later. And things still improving 39 months later.
And many of those reported cases really weren't attributable to genetics but were all secondary due to long-standing "innocuous" conditions like poor diet, alcoholism, hepatic diseases.
Crazy.For me, that's really essential to know that a finding of low serum folate does not become resolved after a few weeks of supplementation and a good follow-up serum folate lab. I've had some low serum levels stretched over several years in the past. Which I wrongly considered over and sufficiently dealt with.
The 3x 1mg folate makes me feel more sleepy - similiar to when I started (or raised) the glucose servings except now it's only in the mornings up to the early afternoons and not all day. Apart from that I notice no drawbacks.
Whereas without P5P and glucose I remember very well that any large amount of folate made me feel weirded-out and uncomfortably light-headed.Overall, this fosters my suspected trajectory: That taking dextrose by itself is not enough to fix everything but that it is a crucial element to regeneration and also demands reevaluation of previously tried measures and supplements to finally unfurl their eluded benefits.
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Has Dr. Stevens treated anyone with severe autism? A family member of mine is 31, severely autistic, non verbal and sometimes bangs his head, necessitating a helmet at times. He is extremely sensitive to many things, his mother has given up on any detox, the reactions to even some B vitamins can be extreme. I haven't read Dr. Stevens book, but am wondering if glucose could help someone like him or if it could trigger too much detox. He is having trouble walking at this point and his mother is losing hope.
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@Sippy I don't know. But I would probably try it. Dr. Stephens may actually reinforce this, who knows, because he has used it apparently with people who had all sorts of brain issues. He really points to all problems as originating in the brain, resulting in hyperglycolysis, resulting in throttling of glucose, resulting in...all sorts of mental illness and issues. So yeah. Yeah. And I can't see how it would cause harm.
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@Sippy said in Glucose loading cures everything?:
Has Dr. Stevens treated anyone with severe autism? A family member of mine is 31, severely autistic, non verbal and sometimes bangs his head, necessitating a helmet at times. He is extremely sensitive to many things, his mother has given up on any detox, the reactions to even some B vitamins can be extreme. I haven't read Dr. Stevens book, but am wondering if glucose could help someone like him or if it could trigger too much detox. He is having trouble walking at this point and his mother is losing hope.
It's definitely worth a try.
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@Sippy
Short answer: Yes, i think it can be helpful.Longer musing: I think people who are neurodivergent and already have issues with neurotransmitters are at higher risk for trouble with the Itaconate shunt, because it causes the GABA shunt, which leads to neurotransmitters being used for ATP instead of what they're supposed to be used for.
There's also a strange phenomenon with autism where people have seen symptoms disappear when they have a fever. If symptoms disappear when the Itaconate shunt is not actived (the fever may indicate the adaptive immune system is activated), maybe debilitating autism is "just" another manifestation (one of many) of the Itaconate shunt (the innate immune system not letting the adaptive immune system do it's job).
(Edit: Actually not sure that a fever may indicate the adaptive immune system is activated; I just very rarely have a fever since my Itaconate shunt issues started - and on the rare occasion I have a fever I've experienced certain symptoms get better. Here's an article about the phenomenon: https://news.mit.edu/2024/understanding-why-autism-symptoms-sometimes-improve-amid-fever-0523)
Hope they can find some relief, it sounds challenging.
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@gentlepotato said in Glucose loading cures everything?:
Here's an article about the phenomenon: https://news.mit.edu/2024/understanding-why-autism-symptoms-sometimes-improve-amid-fever-0523
"developmentally determined" hmm
@ThinPicking said in Propranolol, agression & autism:
Maybe Wakefield was right
@sippy have a read of that thread and the blog link. After GPs insight there.
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C CrumblingCookie referenced this topic on Nov 30, 2024, 10:49 PM
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This post is deleted! -
Bumping this thread. I want to see MORE!
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@Kilgore welcome!
Thanks for the nudge, I've been meaning to share a bit. I'll try to soon, but I'm still having reactivations and immune responses - which I think is positive, but it's quite exhausting.
Is there anything in particular you'd like to know?
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I also would love to see more. Very interesting.
My experience with dextrose is a definite stabilization of mood and euphoria, typically I need 50g to feel this and 50g sugar does the same in terms of direction of effect, but not strength.
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We still use glucose, but our high dose experiment is over. I use it often instead of regular sugar in tea, coffee, etc. I'm on to the next experiment now, low dose nicotine patches. So far I like the effects, but that's for another thread. I'm also going back on Idealabs Mitolipin...for asthma, which I've never had until recently (likely a post covid ailment).
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dam, if I can't see s-Holmes' comments does that mean I'm blocked or something?
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@S-Holmes
Do you have any positive feedback from the glucose loading?Also where did you get the low dose patches? 7mg is the lowest I have seen but I would like 2 or 3 mg.
Thanks
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@LetTheRedeemed said in Glucose loading cures everything?:
dam, if I can't see s-Holmes' comments does that mean I'm blocked or something?
Don't take it personally. This is probably why.
@LetTheRedeemed said in What do you guys think of Trump now that he won:
@Hando-Jin I wish I could meet @ThinPicking
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@ThinPicking hahahahaha
I mean I thought I was fair with S-Holmes, I shared some serious disagreements on a few occasions but thought it was non-malicious… oh well happy new years!
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I was an obnoxious bastard but it was also non-malicious. Now I see in the dark.
Happy New Year!
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Wow seems like an unethical use of blocking when there was no abuse or meanness — totally stopping moving forward scientific inquiry and development... I had thoughtful criticism of glucose loading and now she’s even given up on it.
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Okay, so your experiment can be summarized as:
You spent years reading information, instead of cracking the organism's algorithm yourself, you wasted all that time trying to copy what looked like recommendations and failed, and now, after getting tired of your attempts and feelings, you have only the strength left to search for "miracle drugs" - but it turns out there are none!
I can only tell you that the solution to your problems definitely exists! If you have invested many years in reading information from Ray Peat and others, then you have an excellent foundation and you can absolutely do what it takes to crack the puzzle yourself. No one has provided us with the finished puzzle ready to use and you probably haven't realized it until today (If you say you've applied everything you've learned and still haven't been able to fix the system).
By the way, this brain valve is biological nonsense that the doctor invented to bridge his gap in understanding the organism.
The active thyroid hormone T3 is required to provide enough glucose to the brain
Inflammation, intracellular calcium, nitric oxide, and intracellular estrogen prevent proper cell function, including efficient utilization of glucose
Fructose with glucose as in fruits, honey, and white sugar is a powerful tool for repairing metabolism and the liver, but if the liver is too fatty - fructose can accelerate fat accumulation even more and the balance between glucose and fructose consumption needs to be found depending on the state of the system, such as the level of fat in the liver and the ability of the cells to accept and burn glucose - because excess sugars in relation to the body's ability to utilize it, leads to the same problems as excess fats.
Reduce inflammation, serotonin, nitric oxide, estrogen, PTH, cleanse the digestive system and fat from the liver, supplement thyroid hormones with great skill, combine strength training, body warming and red light, avoid an anti-metabolic, pro-inflammatory diet - good luck (this is of course just super general information)
