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Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

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  • D
    DavidPS
    last edited by Jul 6, 2024, 1:00 PM

    This is an off-label use of antibotics.

    Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

    077acbc9-9f05-49da-9fe5-152dfce4b87d-image.png

    ““Effective health care depends on self-care” - Ivan Illich, 👀
    ☂️

    1 Reply Last reply Reply Quote 0
    • M
      Mauritio
      last edited by Jul 7, 2024, 12:17 PM

      Taurine might help with senescence as well.

      https://www.nature.com/articles/s41598-024-57973-4

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      D 1 Reply Last reply Jul 9, 2024, 9:02 AM Reply Quote 0
      • D
        DavidPS @Mauritio
        last edited by Jul 9, 2024, 9:02 AM

        @Mauritio -Thanks. Senescent cells can not be good to have in the brain. Taurine looks like an inexpensive supplement to help maintain a healthy brain.

        ““Effective health care depends on self-care” - Ivan Illich, 👀
        ☂️

        Y 1 Reply Last reply Jul 10, 2024, 12:23 AM Reply Quote 0
        • Y
          yerrag @DavidPS
          last edited by Jul 10, 2024, 12:23 AM

          @DavidPS
          @Mauritio

          Are senescent cells not naturally going to undergo apoptosis and be done with? If you supply the body with good nutrition and you live a lifestyle that is conducive to supporting an optimal metabolism, why can't you trust the body to know when it is time for a senescent cell to go via apoptosis? Why second guess much less depend on researchers that make yarns and tall tales funded by grants that are mostly biased to favor a mechanistic approach that is driven to profit from making us sick and thereby becoming a cash cow for the evil complex?

          Temporal thinking is the faculty that’s
          engaged by an enriched environment, but it’s
          wrong to call it “thinking,” because it’s simply
          the way organisms exist... - Ray Peat Nov 2017 Newsletter

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          • D
            DavidPS
            last edited by Jul 11, 2024, 8:41 PM

            Exercise is an old family of senoytics.

            Senolytic effects of exercise in human muscles require acute inflammation 2024

            We provide the first evidence demonstrating an attenuated senolytic effect of HIIE in human skeletal muscle under ibuprofen treatments, suggesting the necessity of inflammation for the exercise-induced senolytic outcomes.

            ““Effective health care depends on self-care” - Ivan Illich, 👀
            ☂️

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