Lower limit MB dose to cause significant pigment alteration in urine
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Have any serotonergic sally's experimented in high dose MB oral use? If so what is the minimum efficacious dose one needs to take to experience blue urinary excretion?
If not too high, I would like to experiment along side anti-serotonergic compounds to turn my urine blue as I think it would be a cool party trick.
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@peatilian I wouldn't risk combining MB with anti serotonin compounds at all, especially for a simple party trick. Personally I have came to be a MB hater, as I got great results from doses in the mcg range for a week or two, as per Rays recommendation, but subsequently started getting bad serotonin symptoms. Ever since then, every time I've tried it I've been with met with a mildy unpleasant experience. I probably just don't need it.
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@Dakota I never understood the obsession with it. Would Cardenosine achieve similar effects?
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@peatilian i have been taking 2.5mg 3-4x week and after a few weeks of doing this I’ve just started to notice blue hue in urine. So on days i lift I’ll cut it down to 500-1000mcg, and on days i train Muay Thai I’ll continue doing the 2.5mg or nothing at all.
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@donovan said in Lower limit MB dose to cause significant pigment alteration in urine:
@peatilian i have been taking 2.5mg 3-4x week and after a few weeks of doing this I’ve just started to notice blue hue in urine. So on days i lift I’ll cut it down to 500-1000mcg, and on days i train Muay Thai I’ll continue doing the 2.5mg or nothing at all.
Interesting, I notice a slight color change to green when I dose up to 4mg in a day. Maybe if I start 4mg twice a day my pee will turn blue.
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@peatilian i believe i remember haidut mentioning that it is stored in the body with a half-life of 48 hours(?), and the effective dose is 5mg, so 2.5mg ED or even EOD should be sufficient .
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@Terminator IIRC haidut said that a high dose of vitamin K might be similar to methylene blue, methylene blue is helping to mediate electron transfer while vitamin K is helping to facilitate it. I don't know much about cardenosine, but it looks like it would go well with methylene blue according to haiduts cardenosine thread (mainly because of the succinic acid). More on their combination here: https://twitter.com/GenEnergyNotes/status/1750325138695074263?t=ezyK8iYZRUb6Ws-Q6oGALg&s=19
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Semiregular (everyday or every other day) 5mg reliably dyes my urine blue about 3 to 6 hours after dosing. 10 mg usually gets me two or three blue urinations.
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@stolkovandrew said in Lower limit MB dose to cause significant pigment alteration in urine:
Semiregular (everyday or every other day) 5mg reliably dyes my urine blue about 3 to 6 hours after dosing. 10 mg usually gets me two or three blue urinations.
Thank you for sharing. The most I’ve taken in a day is 4mg which sometimes give me a green color. I was unsure if doubling that dose would give me my wanted blue urine but it sounds like it should. Will report back soon with pics :).
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@peatilian I would assume the required dose depends on utilisation, as MB turns clear after it's used up. It took me a while to get to the doses I listed, mind you. So maybe some kind of "saturation" mechanic is also at play here.
Drinking lots before helps to make the blue more noticeable by making urine less yellow.
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More than 4-5mg I start seeing significant pigmentation, though it's dependent on how active I am. On a sedentary day 8-10 drops of Oxidal tints urine very noticeably, whereas the same dose before a gym session results in very little pigmentation.
This leads me to believe the more you use MB to counter hypoxia, the less pigmented your urine will be at a given dose. -
@peatilian MB should be used in small, even tiny doses while carefully watching for any possible problems. I've taken it countless times and never had my urine change color. It's strange so many people refuse to take it in conservative doses.
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@peatilian I have experimented with MB quite a lot recently, and 5mg is usually what starts turning urine to a different color.
I think Haidut said that it's very rare for someone not in their early twenties to have the urine turn color with less than that.
I also think it was said that an anti-serotonergic compound used with MB would be beneficial to prevent any bad effects from the MAO inhibition.
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Yeah i would say upper dose is 2.5mg, i will most likely drop down to 1mg 2x weekly, on days i lift weights
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Older RPF posts talked about 10mg being the upper limit before potential risks of increased serotonin. In the interview with Mercola Haidut talked about how 1mg per day would with time build to high levels in tissues.
I am still planning to experiment with 10mg per day for a week or so to see if the effect on some viral titers but that's it. After that I don't think I would take more than 1mg per day, and even Peat had said that 0.5mg per day should be enough.
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many people refuse to take it in conservative doses.
I personally settled into taking quite big doses (many mgs), after a few months of experimentation. Hundreds of micrograms were noticeable, but far cry from even 2 mgs.
That said, I've since stepped down from the peak of 8 mg to now 5. Really depends on what you are taking it for, whether you are taking anything else. My MB needs, to keep symptoms at bay go down when I take Aspirin, for ex.
So, for me, comparatively big doses are rational. Can't speak for others
