The benefits of smoking, if any, may be due to lowering endotoxin and estrogen

DavidPS

The Woody Allen clip about tobacco.
https://www.youtube.com/watch?v=Q0ewp4f2pNw

DavidPS

Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?

Abstract

Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other unspecific physical complaints. Several investigators could demonstrate that the SARS-CoV-2 related spike glycoprotein (SGP) attaches not only to ACE-2 receptors but also shows DNA sections highly affine to nicotinic acetylcholine receptors (nAChRs). The nAChR is the principal structure of cholinergic neuromodulation and is responsible for coordinated neuronal network interaction. Non-intrinsic viral nAChR attachment compromises integrative interneuronal communication substantially. This explains the cognitive, neuromuscular and mood impairment, as well as the vegetative symptoms, characterizing post-COVID-19 syndrome. The agonist ligand nicotine shows an up to 30-fold higher affinity to nACHRs than acetylcholine (ACh). We therefore hypothesize that this molecule could displace the virus from nAChR attachment and pave the way for unimpaired cholinergic signal transmission. Treating several individuals suffering from post-COVID-19 syndrome with a nicotine patch application, we witnessed improvements ranging from immediate and substantial to complete remission in a matter of days.

AinmBeo

@DavidPS
So, is this study related to the Haidut comment on the Peat site that nicotine is cholinergic?

https://lowtoxinforum.com/threads/caffeine-increases-pregnenolone-progesterone-in-the-brain.3583/page-2#post-81386

I would consider using microdose nicotine as a patch, for endotoxin issues, except for Haidut's comment that nicotine is cholinergic...

DavidPS

@AinmBeo - A nicotine patch for long-covid (aka post-COVID-19 syndrome) may be worth a try. I never had long-covid and I am only a bystander (with no medical background) trying to keep an open mind for the future.

Nicotine and the nicotinic cholinergic system in COVID-19 (2020)

Abstract

There is an urgent need to address the devastating pandemic, COVID-19, caused by SARS-CoV-2. The efforts to understand the details of this disease in hope of providing effective treatments are commendable. It is clear now that the virus can cause far more damage in patients with comorbid conditions—particularly in those with respiratory, cardiovascular, or immune-compromised system—than in patients without such comorbidities. Drug use can further exacerbate the condition. In this regard, the ill effects of smoking are amply documented, and no doubt can be a confounding factor in COVID-19 progression. Although conflicting hypotheses on the potential role of nicotine in COVID-19 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ACE2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in COVID-19. Thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with COVID-19, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in COVID-19, owing to their varied effects including mood regulation, anti-inflammatory, and purported interference with SARS-CoV-2 entry and/or replication.

RandomUser

Would intravenous or an edema be a viable way of consuming alcohol without the negative gut/endotoxin effects? I'm aware that it's an extremely dangerous way to consume alcohol, but if you were diligent about dosing, it seems you'd avoid that major drawback.

@haidut

smoking tobacco is way more therapeutic on gut issues than chewing the nicotine gum

@RandomUser this type of neuroticism brian johnson approach misses the point . drinking is supposed to be fun

RandomUser

@sneedful

It's about experimenting. I drink for fun and don't plan on stopping drinking. Taking alcohol via enema gets you drunk way quicker by the way. So it's a win-win-win. You get drunk quicker, more drunk overall, and you're potentially sidestepping ones of the biggest drawbacks. Trying new ways of doing things IS fun Doing the same activity the same way a million times over without branching out is boring.

Milk Destroyer

Has anyone here started smoking for the first time after becoming interested in bioenergetics? I'd love to hear someone's experience from this perspective.

@Milk-Destroyer I smoked before and always quit and made a big deal about it . coupled with not great metabolism, smoking kind of sucks. I can see why people do it though.

after peating stopping and starting smoking is no big thing. I stop when I run out and haven't ordered more. I think im switching from hand rolled to pipe though because sometimes id just like to take one or two puffs and then go back to what I and doing rather than wait for an entire handroll to burn out, and putting them out halfway to save them for later usually just ends up wasting it as it crumbles up or whatever.

I mean it's still annoying to run out and not have more and a couple times I had to go to the corner store in a tiff to go buy more at high prices compared to ordering from other country but overall its nbd.

@RandomUser oh ok. have fun with ur bumming alcohol journey

Milk Destroyer

@sneedful Thanks for the insight.

yerrag

I wonder if methylenewhite is a member here. He smokes tobacco by rolling the tobacco itself, and he lights up the tobacco not from a lighter, but from the dying embers of s burning stick. He says that is the right way to light a tobacco, as the smoke it creates is gentle on the lungs.

He didn't elaborate, and at that time I wasn't in a position to ask the right question. But now, I am dealing with a lung issue where my lungs get somehow logged with some water that can be described as edematous, or left unchecked, could develop into pleural effusion, which causes hardness of breathing and can be detected in my ECG graph as a low qrs wave that portends a developing situation that would lead to heart failure, as the heart is heavily dependent (like any other organ) on a stable and rich oxygen supply, and is very dependent on the lungs working very well. And I'm speaking from my experience with heart failure last year, and how it all came about starting from a case of self-induced bronchitis that just snowballed.

My lung issue now has a lot to do with having a lot of dead red blood cells not being cleared from my system, given that there must be an extraordinary amount of them accumulated from the length of time I allowed my body to operate in a hypoxemic (low oxygen state in the blood). I took for granted the severity of being sub 90 in my spO2, and thought the body would eventually right itself back to normal spO2 at the range of 94-99%. That mistake would cost me a heart failure incident which I luckily survived with s trip to the ER and a couple of days at the ICU, and some more days at a regular hospital room.

As I recovered, I find myself not able to regain a hundred percent of my old self. But I also realize that doctors can only save us from dying, but they are simply incapable of restoring us back to our former more healthy state. A major hospitalization is often subconsciously accepted as the start of a downward decline in health, though it is only upon death that more connected and observant people would acknowledge

So I had to dive back into Peat's writings, specifically on a subject that is often mentioned in the COVID saga. It is about the enzyme heme oxygenase. I tried to make sense of heme oxygenase back then, but I couldn't connect. I won't attempt to give you a summary of what it's about, as I find it to be something that can be better understood only when you are motivated well enough to make an effort to understand it. As I am when my health and possibly survival depended on fully understanding it.

You just have to do a keyword search on all of Ray's newsletters and books and pull up all the material you can read and make sense of it. I can do this search easily with a paid search app on my phone.

But anyway, back to the smoke used in your cigar and why I think it matters, as methylenewhite said without giving specifics. I think smoke that comes from the dying embers may burn more completely, and ends up with more carbon dioxide as a product of the slow burning of the tobacco. As opposed to the smoke that comes from the tobacco lit up by a lighter, in which a higher proportion of the product of the incomplete burning is in the form of carbon monoxide.

And this matters greatly. As my lungs right now don't breathe well, and my spO2 levels drop and can go all the way down to 88%. This is the result of the presence of carbon monoxide, which causes my lungs to be edematous, and this water gets in the way of complete air exchange in my alveoli/bronchi, which explains why I am getting less oxygen from my lungs. This is the result of heme oxygenase breaking down the heme from my dead red blood cells which produces free iron and carbon monoxide, both of which are harmful.

There are many ways to mitigate the effect of carbon monoxide, such as methylene blue, red light, etc. This is a long list actually ranging from steroids to simple substances such as CO2. But I am not one to throw the kitchen sink at a problem. It is too messy and when using too many substances at once, I really do get lost in the many trees and lose the forest.

So far, I'm using only methylene blue and red light and carbon dioxide, in the form of carbogen. I would sleep with the red light at a distance far enough so that the dosage would be low enough to allow me to be exposed to it the whole night as I sleep. I have a carbogen machine which I connect to a cannula so I can breathe carbogen the whole night. And I take methylene blue, although I may still be under dosing it as I'm afraid of overdosing.

My breathing is improving, but I feel the rate of my improvement is so glacial. I have to think about more ways to speed it up.

I think smoking tobacco may be something worth trying, as long as I light up my tobacco the right way. Tobacco also delivers nicotinamide or B3, which would also be helpful.

I will be this way until all the dead red blood cells in my system is cleared.

@yerrag maybe you can sweat them out in a sauna?

AlphaCog

Ongoing trial:
Efficacy of Nicotine in Preventing COVID-19 Infection (NICOVID-PREV)
https://clinicaltrials.gov/study/NCT04583410

yerrag

@sneedful said in The benefits of smoking, if any, may be due to lowering endotoxin and estrogen:

@yerrag maybe you can sweat them out in a sauna?

Thanks. It may help.

gg12

@yerrag
I dont know your case at all but I do know that people with sleep apnea caused by small jaws and tongue ties due to improper development have low spo2 levels at night and often have lots of issues as there tongue falls back in thier thoat at night blocking air waking them up giving them a big shot of adrenaline so they cant fall back asleep. Also you cant breath as much air when your airway is obstructed by small jaws.
To fix this do palate expansion then tongue tie release then jaw surgery
Look up "jawhacks " on youtube to learn more its a silent epidemic
Not the ay peat perspective but just something I wanted to share that mainsteam health doesn't talk about

yerrag

@gg12 said in The benefits of smoking, if any, may be due to lowering endotoxin and estrogen:

@yerrag
I dont know your case at all but I do know that people with sleep apnea caused by small jaws and tongue ties due to improper development have low spo2 levels at night and often have lots of issues as there tongue falls back in thier thoat at night blocking air waking them up giving them a big shot of adrenaline so they cant fall back asleep. Also you cant breath as much air when your airway is obstructed by small jaws.
To fix this do palate expansion then tongue tie release then jaw surgery
Look up "jawhacks " on youtube to learn more its a silent epidemic
Not the ay peat perspective but just something I wanted to share that mainsteam health doesn't talk about

I guess you merely scanned my post and missed the part about my lungs becoming edematous being one of two causes my spO2 levels are low. But sleep apnea from obstruction isn't my condition which actually mainstream medicine would point to as a kneejerk response to low spO2 levels during sleep.

I'm not sure what a Peaty explanation to low spO² levels while sleeping is, but I think it would go along the lines of low serum CO2 levels (from poor sugar metabolism) and accompanying high serum acidity from high lactic acid would lead to high breathing rates while asleep, as the respiratory center attempts to correct the high acidity by trying to breathe out CO2 when there really isn't enough serum CO², leading to further lower tissue oxygenation and hypoxia. This. causes the body to have to use the mouth to breathe in addition to the nose, and causes snoring to happen, in an attempt to get more oxygen even while the blood is already carrying enough oxygen already. Even when spO2 levels are high at 99%, people can still snore because the oxygen in blood isn't getting through to the tissues due to low serum CO2.

dapose

@yerrag Hi yerrag! Hey have you ever used the Peaty suggestion of a negative ion generator? Specifically one with very low O3 production. Danny and Ray talked about it years ago on podcasts and I think Ray was brining it up in the context of helping the lungs get rid of serotonin. I have a few units made by Wein products. No idea if this could help your lung issues but I guess it would help something! Also, this makes me think of @haidut post maybe a year or more ago about air filters being a big source for endotoxin! Because the filters (like a furnace air filter) can shred bacteria as it passes through the filter and some percentage of the bacteria parts end up getting breathed in by us and causing havoc. Not a medical term I don’t think but… I also remember reading an article that Saturated fat is specifically protective for the lungs.
Anyways… I’ll see if I can track this stuff down for you if you’re interested or maybe you’ve been there done that!
Peace

yerrag

@dapose

Your timing is perfect! I'm back to having issues sleeping last night. I think it is serotonin buildup due to lungs becoming edematous, and when in bad shape for whatever reason the lungs lose its ability to deactivate serotonin.

I haven't tried using negative ion generators but I think it will help in an incrementally synergistic way, given the edematous condition. I've found using methylene blue, red light, breathing carbogen, vitamin d, eggshell calcium supplementation, magnesium carbonate - altogether help in minimizing the effect of carbon monoxide in causing edema in my lungs, which is the result of heme oxygenase breaking down dead red blood cells producing CO, biliverdin, and iron. I have an ongoing release of previously congested dead rbc's from my lymphatic system which sees no end until all the dead rbc's are flushed out of my system. I'm dealing with the after effects of heart failure which began with bronchitis that caused a mass killing of RBCs that overwhelmed my system. Normally RBCs die and get recycled and/or excreted in small manageable quantities, but in a larger scale the body can't manage it well enough. And I don't think our doctors are trained to handle such cases, which having a Peat viewpoint and approach helps us see through.

So far I've benefited from reading Ray's research and insights into heme oxygenase, and I have an approach to deal with the stressful conditions involving carbon monoxide and iron release by heme oxygenase. The healing and recovery process is slow, and for the next 3 months I imagine I have to be at rest as my breathing is strained and my blood pressure would remain high as a result of my phagocytes having to eat up iron and it's waste be excreted out fecally.

I'd appreciate very much your passing on what info you have on negative ion generators. If I end up buying one, it would just add to my toolbox of useful devices outside of the medical complex, which I haven't regreted acquiring.