The benefits of smoking, if any, may be due to lowering endotoxin and estrogen
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@DavidPS
So, is this study related to the Haidut comment on the Peat site that nicotine is cholinergic?I would consider using microdose nicotine as a patch, for endotoxin issues, except for Haidut's comment that nicotine is cholinergic...
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@AinmBeo - A nicotine patch for long-covid (aka post-COVID-19 syndrome) may be worth a try. I never had long-covid and I am only a bystander (with no medical background) trying to keep an open mind for the future.
Nicotine and the nicotinic cholinergic system in COVID-19 (2020)
Abstract
There is an urgent need to address the devastating pandemic, COVID-19, caused by SARS-CoV-2. The efforts to understand the details of this disease in hope of providing effective treatments are commendable. It is clear now that the virus can cause far more damage in patients with comorbid conditions—particularly in those with respiratory, cardiovascular, or immune-compromised system—than in patients without such comorbidities. Drug use can further exacerbate the condition. In this regard, the ill effects of smoking are amply documented, and no doubt can be a confounding factor in COVID-19 progression. Although conflicting hypotheses on the potential role of nicotine in COVID-19 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ACE2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in COVID-19. Thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with COVID-19, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in COVID-19, owing to their varied effects including mood regulation, anti-inflammatory, and purported interference with SARS-CoV-2 entry and/or replication.
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Would intravenous or an edema be a viable way of consuming alcohol without the negative gut/endotoxin effects? I'm aware that it's an extremely dangerous way to consume alcohol, but if you were diligent about dosing, it seems you'd avoid that major drawback.
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smoking tobacco is way more therapeutic on gut issues than chewing the nicotine gum
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@RandomUser this type of neuroticism brian johnson approach misses the point . drinking is supposed to be fun
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It's about experimenting. I drink for fun and don't plan on stopping drinking. Taking alcohol via enema gets you drunk way quicker by the way. So it's a win-win-win. You get drunk quicker, more drunk overall, and you're potentially sidestepping ones of the biggest drawbacks. Trying new ways of doing things IS fun Doing the same activity the same way a million times over without branching out is boring.
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Has anyone here started smoking for the first time after becoming interested in bioenergetics? I'd love to hear someone's experience from this perspective.
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@Milk-Destroyer I smoked before and always quit and made a big deal about it . coupled with not great metabolism, smoking kind of sucks. I can see why people do it though.
after peating stopping and starting smoking is no big thing. I stop when I run out and haven't ordered more. I think im switching from hand rolled to pipe though because sometimes id just like to take one or two puffs and then go back to what I and doing rather than wait for an entire handroll to burn out, and putting them out halfway to save them for later usually just ends up wasting it as it crumbles up or whatever.
I mean it's still annoying to run out and not have more and a couple times I had to go to the corner store in a tiff to go buy more at high prices compared to ordering from other country but overall its nbd.
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@RandomUser oh ok. have fun with ur bumming alcohol journey
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@sneedful Thanks for the insight.
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I wonder if methylenewhite is a member here. He smokes tobacco by rolling the tobacco itself, and he lights up the tobacco not from a lighter, but from the dying embers of s burning stick. He says that is the right way to light a tobacco, as the smoke it creates is gentle on the lungs.
He didn't elaborate, and at that time I wasn't in a position to ask the right question. But now, I am dealing with a lung issue where my lungs get somehow logged with some water that can be described as edematous, or left unchecked, could develop into pleural effusion, which causes hardness of breathing and can be detected in my ECG graph as a low qrs wave that portends a developing situation that would lead to heart failure, as the heart is heavily dependent (like any other organ) on a stable and rich oxygen supply, and is very dependent on the lungs working very well. And I'm speaking from my experience with heart failure last year, and how it all came about starting from a case of self-induced bronchitis that just snowballed.
My lung issue now has a lot to do with having a lot of dead red blood cells not being cleared from my system, given that there must be an extraordinary amount of them accumulated from the length of time I allowed my body to operate in a hypoxemic (low oxygen state in the blood). I took for granted the severity of being sub 90 in my spO2, and thought the body would eventually right itself back to normal spO2 at the range of 94-99%. That mistake would cost me a heart failure incident which I luckily survived with s trip to the ER and a couple of days at the ICU, and some more days at a regular hospital room.
As I recovered, I find myself not able to regain a hundred percent of my old self. But I also realize that doctors can only save us from dying, but they are simply incapable of restoring us back to our former more healthy state. A major hospitalization is often subconsciously accepted as the start of a downward decline in health, though it is only upon death that more connected and observant people would acknowledge
So I had to dive back into Peat's writings, specifically on a subject that is often mentioned in the COVID saga. It is about the enzyme heme oxygenase. I tried to make sense of heme oxygenase back then, but I couldn't connect. I won't attempt to give you a summary of what it's about, as I find it to be something that can be better understood only when you are motivated well enough to make an effort to understand it. As I am when my health and possibly survival depended on fully understanding it.
You just have to do a keyword search on all of Ray's newsletters and books and pull up all the material you can read and make sense of it. I can do this search easily with a paid search app on my phone.
But anyway, back to the smoke used in your cigar and why I think it matters, as methylenewhite said without giving specifics. I think smoke that comes from the dying embers may burn more completely, and ends up with more carbon dioxide as a product of the slow burning of the tobacco. As opposed to the smoke that comes from the tobacco lit up by a lighter, in which a higher proportion of the product of the incomplete burning is in the form of carbon monoxide.
And this matters greatly. As my lungs right now don't breathe well, and my spO2 levels drop and can go all the way down to 88%. This is the result of the presence of carbon monoxide, which causes my lungs to be edematous, and this water gets in the way of complete air exchange in my alveoli/bronchi, which explains why I am getting less oxygen from my lungs. This is the result of heme oxygenase breaking down the heme from my dead red blood cells which produces free iron and carbon monoxide, both of which are harmful.
There are many ways to mitigate the effect of carbon monoxide, such as methylene blue, red light, etc. This is a long list actually ranging from steroids to simple substances such as CO2. But I am not one to throw the kitchen sink at a problem. It is too messy and when using too many substances at once, I really do get lost in the many trees and lose the forest.
So far, I'm using only methylene blue and red light and carbon dioxide, in the form of carbogen. I would sleep with the red light at a distance far enough so that the dosage would be low enough to allow me to be exposed to it the whole night as I sleep. I have a carbogen machine which I connect to a cannula so I can breathe carbogen the whole night. And I take methylene blue, although I may still be under dosing it as I'm afraid of overdosing.
My breathing is improving, but I feel the rate of my improvement is so glacial. I have to think about more ways to speed it up.
I think smoking tobacco may be something worth trying, as long as I light up my tobacco the right way. Tobacco also delivers nicotinamide or B3, which would also be helpful.
I will be this way until all the dead red blood cells in my system is cleared.
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@yerrag maybe you can sweat them out in a sauna?
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Ongoing trial:
Efficacy of Nicotine in Preventing COVID-19 Infection (NICOVID-PREV)
https://clinicaltrials.gov/study/NCT04583410 -
@sneedful said in The benefits of smoking, if any, may be due to lowering endotoxin and estrogen:
@yerrag maybe you can sweat them out in a sauna?
Thanks. It may help.
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@yerrag
I dont know your case at all but I do know that people with sleep apnea caused by small jaws and tongue ties due to improper development have low spo2 levels at night and often have lots of issues as there tongue falls back in thier thoat at night blocking air waking them up giving them a big shot of adrenaline so they cant fall back asleep. Also you cant breath as much air when your airway is obstructed by small jaws.
To fix this do palate expansion then tongue tie release then jaw surgery
Look up "jawhacks " on youtube to learn more its a silent epidemic
Not the ay peat perspective but just something I wanted to share that mainsteam health doesn't talk about -
@gg12 said in The benefits of smoking, if any, may be due to lowering endotoxin and estrogen:
@yerrag
I dont know your case at all but I do know that people with sleep apnea caused by small jaws and tongue ties due to improper development have low spo2 levels at night and often have lots of issues as there tongue falls back in thier thoat at night blocking air waking them up giving them a big shot of adrenaline so they cant fall back asleep. Also you cant breath as much air when your airway is obstructed by small jaws.
To fix this do palate expansion then tongue tie release then jaw surgery
Look up "jawhacks " on youtube to learn more its a silent epidemic
Not the ay peat perspective but just something I wanted to share that mainsteam health doesn't talk aboutI guess you merely scanned my post and missed the part about my lungs becoming edematous being one of two causes my spO2 levels are low. But sleep apnea from obstruction isn't my condition which actually mainstream medicine would point to as a kneejerk response to low spO2 levels during sleep.
I'm not sure what a Peaty explanation to low spO² levels while sleeping is, but I think it would go along the lines of low serum CO2 levels (from poor sugar metabolism) and accompanying high serum acidity from high lactic acid would lead to high breathing rates while asleep, as the respiratory center attempts to correct the high acidity by trying to breathe out CO2 when there really isn't enough serum CO², leading to further lower tissue oxygenation and hypoxia. This. causes the body to have to use the mouth to breathe in addition to the nose, and causes snoring to happen, in an attempt to get more oxygen even while the blood is already carrying enough oxygen already. Even when spO2 levels are high at 99%, people can still snore because the oxygen in blood isn't getting through to the tissues due to low serum CO2.
