Strong Sistas finally posted an interview with Dr. Ray Peat - The Basics Of Pro-Metabolic
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@DavidPS Good to know thanks..
Any other video recommendations for people new to this sphere such as myself?
I've seen one Danny Roddy and Nate Lawrence video. -
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That is such an interesting comment on the benefits of blood donation.
Does anbody know more about that?He talks about it at about 4:58
"Besides getting rid of the iron, as you start aging there are signals like exosomes or extra-cellular vesicles that carry information that excelerates aging and if you just get rid of those, you are tending to reverse the aging process"
From what Ive read these exosomes can carry inflammatory cytokines like TNFa or IL-6 and others. But they can also carry the so called senescence factors (SASP), which create a circle of contionous inflammation.
So in that sense donating blood works against senscent cells and inflammation, which are two main cotributors to the aging process.
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Another take away from this interview was the exact mechanism by which calcium helps with heavy metal toxicity. It's about PTH, which makes the body retain heavy metals, so by consuming calcium (and thus lowering PTH) you stop accumulating heavy metals.
So by using that logic, Vitamin D and K should also be anti-heavy metal.
Another nutrient that keeps coming up when talking about heavy metals is selenium.
Not only does it protects from oxidative stress, caused by heavy metals, it also binds with heavy metals forming less toxic, more excretable -selenite molecules.Here, selenium deficiency has been shown to double PTH levels:
"This group had a 2-fold increase in parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in plasma."
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@Mauritio - Good find and great connection!
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@gg12 said in Strong Sistas finally posted an interview with Dr. Ray Peat - The Basics Of Pro-Metabolic:
@DavidPS Good to know thanks..
Any other video recommendations for people new to this sphere such as myself?
I've seen one Danny Roddy and Nate Lawrence video.Georgi Dinkov videos on Youtube, aka "Haidut" from this forum and the old RayPeatforum. He also posts at his own blog http://haidut.me/
Great find @DavidPS, and interesting info @Mauritio, can't wait to check it out.
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Nice to see you making the effort connecting the dots.
I've been wondering why in one of his last newsletters Ray would say that when the body is in the process of drawing calcium from the bones, in an osteoclastic process, it cannot be at the same time in a full optimal mitochondrial respiratory mode where among other things CO2 is being produced. I am paraphrasing a lot here but the idea is that calcium balance plays a vital role in enabling mitochondrial metabolism. Which is why these factors need to be considered instead of just reaching out for thyroid supplementation, which many tend to do with poor results when taking thyroid without considering other factors that affect metabolism.
I was hoping Ray would explain more in subsequenr newsletters, as I felt he wasn't doing as much new research into publications at that point, and he was connecting more dots from his prior research over the years. And the best from him was yet to come. But his passing overtook him.
Do you have any more thoughts on why calcium and it's balance, with the presence of osteoblastic activity, would favor mitochondrial respiration?
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@yerrag said in Strong Sistas finally posted an interview with Dr. Ray Peat - The Basics Of Pro-Metabolic:
I've been wondering why in one of his last newsletters Ray would say that when the body is in the process of drawing calcium from the bones, in an osteoclastic process, it cannot be at the same time in a full optimal mitochondrial respiratory mode where among other things CO2 is being produced.
From this paper Calcium paradox disease: Calcium deficiency prompting secondary hyperparathyroidism and cellular calcium overload
in Page 7:Mitochondria are conspicuously affected by
Ca overload [151]. These organelles have the capacity
to store significant amounts of Ca in the form of biologi-
cally inactive amorphous calcium phosphate, but when
their buffer capacity is overtaxed mitochondrian physi-
ology is disrupted with severe reduction of oxidative
phosphorylation, resulting in an ATP deficit that in turn
diminishes the effectiveness of the Ca pump with fur-
ther cellular Ca overload. Elevation of [Ca] stimulates
Ca-activated neutral protease [7,8] and phospholipases
[6], affecting the pathophysiological process of muscu-
lar dystrophy [152] and other diseases characterized by
cellular Ca dishomeostasis [146] -
@Mauritio said in Strong Sistas finally posted an interview with Dr. Ray Peat - The Basics Of Pro-Metabolic:
So by using that logic, Vitamin D and K should also be anti-heavy metal.
Re: Vitamin D -- No.
It facilitates the absorption of heavy metals from the gut.
Confirmed myself by idealab's multiple hair and nail analyses.
I have several posts on this as well as some reference research on the formally known as RPF. -
@Lejeboca said in Strong Sistas finally posted an interview with Dr. Ray Peat - The Basics Of Pro-Metabolic:
@yerrag said in Strong Sistas finally posted an interview with Dr. Ray Peat - The Basics Of Pro-Metabolic:
I've been wondering why in one of his last newsletters Ray would say that when the body is in the process of drawing calcium from the bones, in an osteoclastic process, it cannot be at the same time in a full optimal mitochondrial respiratory mode where among other things CO2 is being produced.
From this paper Calcium paradox disease: Calcium deficiency prompting secondary hyperparathyroidism and cellular calcium overload
in Page 7:Mitochondria are conspicuously affected by
Ca overload [151]. These organelles have the capacity
to store significant amounts of Ca in the form of biologi-
cally inactive amorphous calcium phosphate, but when
their buffer capacity is overtaxed mitochondrian physi-
ology is disrupted with severe reduction of oxidative
phosphorylation, resulting in an ATP deficit that in turn
diminishes the effectiveness of the Ca pump with fur-
ther cellular Ca overload. Elevation of [Ca] stimulates
Ca-activated neutral protease [7,8] and phospholipases
[6], affecting the pathophysiological process of muscu-
lar dystrophy [152] and other diseases characterized by
cellular Ca dishomeostasis [146]That sounds like a good answer to yerrags question above. We don't want intra-cellular calcium.
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With regard to the Calcium paradox, CO2 is involved:
Peatbot.com: Yes, carbon dioxide (CO2) is involved in the calcium paradox. The context provided discusses how CO2 plays a role in maintaining calcium in an ionized, water-soluble state, which prevents it from accumulating inside cells. When CO2 levels are low, such as during hyperventilation, calcium tends to move into cells, leading to muscle cramps and other issues. This movement of calcium into cells when CO2 is absent or reduced is part of the calcium paradox, where calcium behaves differently depending on the presence of CO2 and other factors like ADP levels. CO2 helps to keep calcium outside of cells, and its absence can lead to increased intracellular calcium, which can have various physiological effects.
Peatbot.com: To increase CO2 levels in your body, you can consider the following methods based on the provided context:
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Re-breathing Technique: Breathe into a paper bag for a minute or two at a time until you feel a sensation of suffocation, then breathe fresh air. Doing this two or three times a day can help increase CO2 levels.
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High Altitude Exposure: Spending time at high altitudes can naturally increase CO2 levels in your body. This is because the body adapts to the lower oxygen levels by increasing CO2 concentration.
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CO2 Enrichment for Injuries: For localized treatment, such as for a broken bone or sprained ankle, you can place the injured area in a plastic bag filled with carbon dioxide. This method has been used in some European hospitals to enhance healing.
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Dietary Adjustments: Shifting your diet away from polyunsaturated fats can help increase CO2 levels. These fats interfere with glucose metabolism, and burning glucose produces more CO2 compared to fat metabolism.
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Carbonated Hot Springs: Visiting carbonated hot springs can help your body absorb CO2 through the skin, as the body has an affinity for carbon dioxide.
These methods are suggested in the context provided and may not be suitable for everyone. It's important to consider individual health conditions and consult with a healthcare professional if needed.
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@Lejeboca Thanks a lot!