I need x-rays
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Secondly, depending on the ratios of gelatin to other proteins, the amount of carrot salad, aspirin and cynomel doses, these substances may not be benign (!).
Could you expound on this point?
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@happyhanneke do you hold a smart phone for extended periods of time?
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@LetTheRedeemed said in I need x-rays:
do you hold a smart phone for extended periods of time?
Well seen: it could explain many things.
Pain and arthritis suspected
If general localization (hands, neck, ankles) arthritis inflammation is due to two possible factors, bacteria or a molecule (wga from wheat).
Here it’s not the case. If testimony is asked, see Jacqueline Lagacée who‘s suffered from very painful arthritis in her hands (immune cause).DavidsPS has made a good suggestion to optimize carburation (appropriate fuel) but I’m going to put in excerpt some citations from ray PEAT, and you’ll make your mind to see you are going to take it into account or left it aside. Note it’s only a part of the problem.
Therapeutic effects of niacinamide
From Ray PEAT
“It’s the stored PUFA, released by stress or hunger, that slow metabolism. Niacinamide helps to lower free fatty acids, and good nutrition will allow the liver to slowly detoxify the PUFA, if it isn’t being flooded with large amounts of them. A small amount of coconut oil with each meal will increase the ability to oxidize fat, by momentarily stopping the anti-thyroid effect of the PUFA. Aspirin is another thing that reduces the stress-related increase of free fatty acids, stimulating metabolism. Taking a thyroid supplement is reasonable until the ratio of saturated fats to PUFA is about 2 to 1.”“In the same way that topical lactate can cause vasodilatation and disturbed energy metabolism (Rnedle, et al., 2001), topical niacinamide, progesterone, vitamin K, and coenzyme Q10 can improve the metabolism and function of the local tissues.”
“The same better-late-than-never philosophy can be applied to Alzheimer’s disease, Parkinson’s disease, and other degenerative nerve diseases. Aspirin protects against several kinds of toxicity, including excitotoxicity (glutamate), dopamine toxicity, and oxidative free radical toxicity. Since its effects on the mitochondria are similar to those of thyroid (T3), using both of them might improve brain energy production more than just thyroid. (By activating T3, aspirin can sometimes increase the temperature and pulse rate.)Magnesium, niacinamide, and other nerve protective substances work together.”
“Glucose and niacinamide work very closely with each other, and with thyroid hormone, in the maintenance and repair of cells and tissues. When one of these energy-producing factors is lacking, the changes in cell functions – a sort of pre-inflammatory state – activate corrective processes.”
“Although this is an ecological problem, it is possible to decrease the damage by avoiding the polyunsaturated fats and the many toxins that synergize with them, while increasing glucose, niacinamide, carbon dioxide, and other factors that support high energy metabolism, including adequate exposure to long wavelength light and avoidance of harmful radiation. As long as the protective factors are present, increased amounts of protective factors such as progesterone, thyroid, sugar, niacinamide, and carbon dioxide can be used therapeutically and preventatively.”“The features of the stress metabolism include increases of stress hormones, lactate, ammonia, free fatty acids, and fat synthesis, and a decrease in carbon dioxide. Factors that lower the stress hormones, increase carbon dioxide, and help to lower the circulating free fatty acids, lactate, and ammonia, include vitamin B1 (to increase CO2 and reduce lactate), niacinamide (to reduce free fatty acids), sugar (to reduce cortisol, adrenaline, and free fatty acids), salt (to lower adrenaline), thyroid hormone (to increase CO2). Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis (Marshall, et al., 1976).”
“In some of the publications claiming that resveratrol increases lifespan, it was reported that niacinamide had the opposite effect, suppressing Sir2, the longevity gene, and shortening the organism’s lifespan. To put their claims into context, it’s helpful to look at a variety of experiments involving treatment with niacinamide.
It protects nerves, vascular cells, insulin-producing cells in the pancreas, and a variety of other types of cell from cell death produced by lack of oxygen, excitotoxicity, endotoxin, and a variety of stressors and toxins. (Niacinamide acts in many ways as a negation of resveratrol; for example, resveratrol interferes with the ability of the beta cells to secrete insulin [Szkudelski, 2007]).
Niacinamide protects mitochondrial respiration from many of the age-related factors that can damage mitochondria and decrease energy production. Lipopolysaccharide, the bacterial endotoxin, increases the production of the free radical nitric oxide, leading to the secretion of inflammatory mediators and the suppression of energy production by the mitochondria. These effects are blocked by niacinamide (Fukuzawa, et al., 1997). Calorie restriction also protects mitochondrial respiration, in yeasts (Lin, et al., 2002) and rats (Broderick, et al., 2002)
The “replicative lifespan” of human cells in vitro is extended by treatment with niacinamide (Kang, et al., 2006).
In an experiment with human keratinocytes in vitro, resveratrol had the opposite effect, reducing their ability to divide (Blander, et al., 2009). By the definitions of “aging” used by the advocates of the rate-of-living theory, this experiment suggests that resveratrol causes premature aging. Estrogen has a similar effect on keratinocytes. Resveratrol, nitric oxide, and estrogen, unlike niacinamide, suppress mitochondrial respiration. Resveratrol inhibits the formation of progesterone (Chen, et al., 2007), which is synthesized in mitochondria.”“The amino acid theanine, found in tea, has been reported to decrease the amount of serotonin in the brain, probably by decreasing its synthesis and increasing its degradation. This seems to be the opposite of the processes in hibernation. Progesterone, thyroid, and niacinamide (not nicotinic acid or inositol hexanicotinate) are other safe substances that help to reduce serotonin formation, and/or accelerate its elimination. (Niacinamide seems to increase serotonin uptake.)”
“Niacinamide, by reducing lipolysis, would be another anti-inflammatory agent that could help to interrupt the degenerative processes initiated by exposure to radiation.”
“The “treatment” for intracellular fatigue consists of normalizing thyroid and steroid metabolism, and eating a diet including fruit juice, milk, some eggs, liver, and gelatin, assuring adequate calcium, potassium, sodium, and magnesium, and using supplements of niacinamide (B3), aspirin, and carbon dioxide when necessary.”
“Niacinamide, progesterone, sugar, carbon dioxide, and red light protect against both free fatty acids and prostaglandins.”“The foods that nourish the patient well enough to support healing while permitting energy reserves to be built up are also the foods that don’t interfere with the hormones, that don’t cause spurious excitation of the tissues. The polyunsaturated fats directly stimulate the stress hormones, activate the excitatory amino acid signals, and directly excite cells, while the saturated fats have opposite effects, and are anti-inflammatory, and also don’t interfere with mitochondrial function. When we eat more carbohydrate than can be oxidized, some of it will be turned into saturated fats and omega-9 fats, and these will support mitochondrial energy production. Carbohydrates in the diet also help to decrease the mobilization of fatty acids from storage; niacinamide and aspirin support that effect.”
“Niacinamide, by lowering free fatty acids and regulating the redox system, supporting sugar oxidation, is useful in the whole spectrum of metabolic degenerative diseases.”
“The inflammatory factors that can promote cell growth can, with just slight variation, deplete cellular energy to the extent that the cells die from the energetic cost of the repair process, or mutate from defective repairs. Niacinamide can have an “anti-inflammatory” function, preventing death from multiple organ failure, by interrupting the reactions to nitric oxide and peroxynitrile (Cuzzocrea, et al., 1999). The cells’ type, environment, and history determine the different outcomes.”
“The same simple metabolic therapies, such as thyroid, progesterone, magnesium, and carbon dioxide, are appropriate for a great range of seemingly different diseases. Other biochemicals, such as adenosine and niacinamide, have more specific protective effects, farther downstream in the “cascade” effects of stress.”
“Thyroid hormone, vitamins A and E, niacinamide (to inhibit systemic lipolysis), magnesium, calcium, progesterone, sugar, saturated fats, and gelatin all contribute in basic ways to prevention of the inflammatory states that eventually lead to the amyloid diseases. The scarcity of degenerative brain disease in high altitude populations is consistent with a protective role for carbon dioxide.”
“Eliminating polyunsaturated fats from the diet is essential if the bystander effect is eventually to be restrained. Aspirin and salicylic acid can block many of the carcinogenic effects of the PUFA. Saturated fats have a variety of anti-inflammatory and anticancer actions. Some of those effects are direct, others are the result of blocking the toxic effects of the PUFA. Keeping the stored unsaturated fats from circulating in the blood is helpful, since it takes years to eliminate them from the tissues after the diet has changed. Niacinamide inhibits lipolysis. Avoiding overproduction of lipolytic adrenaline requires adequate thyroid hormone, and the adjustment of the diet to minimize fluctuations of blood sugar.”“Niacinamide inhibits the release of free fatty acids from the tissues, and thyroid sustains the oxidation of glucose.”
“Niacinamide, like progesterone, inhibits the production of nitric oxide, and also like progesterone, it improves recovery from brain injury (Hoane, et al., 2008).”
“Since the blood becomes more concentrated, viscous, and clottable during the night (especially during long winter nights), the risk of a heart attack or stroke would probably be reduced by drinking orange juice before getting out of bed (and at bed-time), to dilute the blood and decrease adrenaline and the free fatty acids, which contribute to the increased tendency to form clots in the morning. (Assanelli, et al., discuss the importance of adrenaline in morning/winter sudden death; Antoniades and Westmoreland show that the availability of glucose can override major promoters of clotting and bleeding.)
Things to reduce the stress-related coagulopathies: Sugar and niacin to minimize the liberation of fatty acids, progesterone and thyroid to protect against estrogen and to avoid hypoglycemia (which increases adrenaline and free fatty acids and accelerates clotting), magnesium and gelatin (or glycine), to protect against intracellular calcium overload and hypoxia, and vitamin E and salicylic acid for anti-inflammatory effects, are major nutrients that protect the circulatory system against clotting, bleeding, edema, and tumefaction.”
Dr. Ray Peat Ph.D.
https://www.functionalps.com/blog/2012/03/20/ray-peat-phd-on-therapeutic-effect-of-niacinamide/Therapeutic effects of niacinamide
Carbon dioxide (CO2), niacinamide (B3) and aspirin are protective towards mitochondrial respiration.
“Niacinamide, used in moderate doses, can safely help to restrain the excessive production of free fatty acids, and also helps to limit the wasteful conversion of glucose into fat. There is evidence that diabetics are chronically deficient in niacin. Excess fatty acids in the blood probably divert tryptophan from niacin synthesis into serotonin synthesis.”
Ray Peat
Editor’s Note: Ray PEAT advices 50 – 70 mg niacinamide, beginning with a low amount.
In another question form readers, RP advices to take 10 mg B3 from time to time to enhance mitochondrial breathing, when things have returned to a more “normal” state.
Comment LucH: I’ll make an association of several points; just niacinamide is not going to solve painful tensions.Mind niacin (skin flush) if above 20-25 mg. Take niacinamide.
Mind the kind of B6. B6 PLP is fine but some people won’t tolerate more than 20-25 mg (brain sensitive). When taking high dose B6 (100 mg), we should begin with moderate amount. Make staples and pause. I’ve done it so; 5 days per week, for 3 weeks. Pause one week, Again 3 weeks. Stop. 3 or 4 times a year if needed. Excess B6 is going to bring problem with GABA (self-protection due to residual molecules). -
It is not clear to me what x-rays are going to do to improve your situation. It may give you a label (such as arthritis) and provide a basis for your doctor to prescribe drugs, but it will not make your condition better.
'Text neck' and poor posture are common issues that need to be ruled out be before going on to the medical treadmill. In the past, I have had some upper body (neck and shoulders) issues associated with poor posture from extensive computer work. It is very common these days and in my case DYI treatment worked.
Here is a generic link to some exercises to consider:
https://www.youtube.com/results?search_query=forward+head+posture+painThe best way to cure a dietary disease is to improve the diet.
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@DavidPS said in I need x-rays:
It is not clear to me what x-rays are going to do
It's probably not x-rays but red-light therapy.
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I am in touch with Danny so most of what I do has been discussed with him.
I never have cold hands or feet.
I don't think I can take a lot of aspirin. I just take a tiny amount and I already get bleeding gums and if I accidentally get a small cut it bleeds like crazy. I take vit K too but it doesn't seem to make it better. The small amount is ok but if I take more I'm worried about the bleeding, even when I brush my teeth.Yes I do hold a smart phone for an extended period of time. I'm as addicted as anybody else
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@LucH
wait, what does this mean? I have been using red light lately
Didn't even think about that. -
@happyhanneke said in I need x-rays:
what does this mean? I have been using red light lately
The Therapeutic Effects of Red and Near-Infrared Light (2017)
http://valtsus.blogspot.com/2017/05/the-therapeutic-effects-of-red-and-near.html
“Previous studies have shown that exposing cells to a particular wavelength of light, 670 nanometers, toward the red end of the visible spectrum, causes their energy-producing mitochondria to boost production of adenosine triphosphate, which powers the cells.” (Science 2017)
Near-infrared penetrates the tissue better than red light, so it’s more commonly used for treating body parts that are under the skin (brain, glands, joints, muscles). Visible red light is more commonly used in the treatment of wounds or skin diseases.
The right dose
Low-to-moderate doses of light are often described as stimulating and high doses as inhibitory, because some markers that can be increased by low doses of light, have been shown to decrease with excessive light doses. The exact mechanism of biphasic dose-response is not known, but it might be related to excessive formation of reactive oxygen species (ROS). -
@happyhanneke said in I need x-rays:
Yes I do hold a smart phone for an extended period of time. I'm as addicted as anybody else
I try to prop my phone again something as much as possible so I am not actually holding it when I use it. I have been looking for something to hold with the phone in it when I do have to have it in hand, so I am touching it as little as possible.
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@LucH
I actually do have Helycrisse. How do you apply it? You use a carrier oil? -
@happyhanneke said in I need x-rays:
I actually do have Helycrisse. How do you apply it? You use a carrier oil?
Not obliged to but the penetration will be easier. Advised to do so.
2 possibilities with oil + EO- I have a small pot with 10 ml oil ( tsp). I put a finger in it and rub the skin. Afterwards I take 2 drops EO on a finger and I rub the place where it is needed. x 2. Not very practical but quicker. Total 4 drops, 3 times a day.
- I mix oil and EO in the pot.
Mind the proportions: 40 % EO.
For 10 ml oil, it makes 4 ml EO (4 x 20 drops). Not cheap so.
Try to add lavendula or tea tree. lavendula if you don't take aspirin.
I'd add 1/3 anti-pain EO if no aspirin. But with no irritable touch.
Edit: Instead of oil, you can use body milk if you don't mix the whole thing.
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@happyhanneke said in I need x-rays:
I am in touch with Danny so most of what I do has been discussed with him.
awesome
I never have cold hands or feet.
cool
I don't think I can take a lot of aspirin. I just take a tiny amount and I already get bleeding gums and if I accidentally get a small cut it bleeds like crazy. I take vit K too but it doesn't seem to make it better. The small amount is ok but if I take more I'm worried about the bleeding, even when I brush my teeth.
got it. I'd suggest trying to reverse a vitamin K deficiency, with just prolonged higher doses of vitamin K (K2MK4 is a must, idealabs is suggested). If you can't go higher dose on the aspirin, I'd consider getting a couple bottles and going reasonably high dose topical on the belly button, and orally.
Danny said how when he was reaching 3 g of aspirin, he was bleeding like crazy, and unbeknownst to him had likely induced a vit K deficiency, upped 5mg to 10mg vit K and that went away pretty quickly. Maybe you need more. keep up calcium and vit D and you're killin it.
All these nutrients will be important cofactors in the improvement of arthritis, anyway!
Yes I do hold a smart phone for an extended period of time. I'm as addicted as anybody else
same, but after I deleted a game I was seriously spending too much time on, my own arthritic pains have gone away. Also, I try to limit things on the phone, that I could do on a computer instead, that seems to gives less centralized radiation.
I don't think there's a way around this. I remember Ray commenting how he'd be emailing people back and forth about their problems for years, and then find out they are on their smart phone all the time. Note: radiation mitigating devices has not worked for me (still keep them on my phone)
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@DavidPS Great point DavidPS. I second this. One should be doing the things that will fix arthritis anyway, so knowing if what you've got is arthritis is a moot point.
If you google what a doctor will prescribe, it'd basically be painkillers/NSAID's, steroids, and DMARDs (supposedly stop progression of arthritis)...
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@LetTheRedeemed said in I need x-rays:
I'd suggest trying to reverse a vitamin K deficiency, with just prolonged higher doses of vitamin K (K2MK4 is a must,
Masterjohn says K2 MK7 for fluidity problems is optimal, better than K1.
Mind the protection (oxidation) for MK7. Rather fragile (3 months if not well encapsulated with e.g. rosmarinus). So No liquid form with MK7.
Excerpt:
There is reason to think MK-7 would be better at supporting blood clotting.
“MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.”
https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/ -
@LucH I agree Mk7 better than K1, but apparently Mk7 functions like a surrogate of Mk4 -- it's sole reason that I recall for it's continued support is that it's half life is twice as long, but, that's likely because it's used half as effectively. Apparently K1 itself is converted to Mk4.
https://lowtoxinforum.com/threads/k2-mk4-or-mk7.13828/page-4Based on this, I believe it would be better to just continually consume more Mk4.
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@LetTheRedeemed said in I need x-rays:
I believe it would be better to just continually consume more Mk4.
Yes, I do so (MK4) but once a week I take the full spectrum.
I won't account much on the conversion rate (K1 => needs for MK4 and MK7), very weak (15%) and random. -
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@LetTheRedeemed , Ray recommends gelatin to be about 1/3 of the total amount of protein since gelatin is missing essential amino acids.
For me, the ratio has to be even lower, of about 1/4, not produce negative effects such as brittle nails and hair. -
@LetTheRedeemed
I've been taking VitK by Thorne. As seen below. Would that mean 1-2 tablets a day?
I only take one every other day so probably can take more. I don't like to take a lot of supplements that's why I don't take much at the moment. I do think aspirin is important and that's why I take this as well.
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@happyhanneke said in I need x-rays:
Would that mean 1-2 tablets a day?
half-life of K2 MK7 is 72 hours.
I’ve had a discussion on RPF about the dosage of vitamin K2. How much is too much?
I won’t recommend taking more than 2 mg / day, given the fact that the menaquinones (K2 family) are broken down into menadiones, which can be "toxic" If repeated.
http://ajplung.physiology.org/content/ajplung/262/5/L637.full.pdfMenadione in excess clearly affects the mitochondrial function. (5)
However there is no reported health risk when taking K2. Excess K2 is excreted through urine and feces (through bile). No direct adverse effect doesn’t mean there is no impact on energy level. This is a personal comment. It depends on the way the body neutralizes an excess oral supplement.
Mind excess alpha-tocopherols too (vitamin E) because it may interfere with synthesis of K2. (6- 7). And do not take at the same meal.
Also if you take phytonutrients as AINS (curcumine or aspirin) because it affects cytochrome P450 (detox pathway). You need a recovery period between 2 cures.References
5. http://jcs.biologists.org/content/106/1/309
6. http://health.oregonstate.edu/biblio/vitamin-e-decreases-extra-hepatic-menaquinone-4-concentrations-rats-fed-menadione-or
7. http://www.pubpdf.com/pub/22707266/Vitamin-E-decreases-extra-hepatic-menaquinone-4-concentrations-in-rats-fed-menadione-or-phylloquinon
α-Toco may interfere with the side chain removal of phylloquinone (PK) to form menadione (MN) as an intermediate for synthesis of tissue-specific menaquinone-4 (MK-4).Dosage
K1= 45 mcg.
Enough to improve the level of artery calcification and cardiac mortality. It depends on the interaction between A D K vitamins.
K2 type MK4: 45 mg (45.000 mcg).
Recommended to decarboxylate the Osteocalcin level.
K2 type MK7: 240 mcg for diabetics and obese people. Level recommended in the prevention of atherosclerosis, diabetes, osteoporosis, obesity, etc.
From « Dosage optimum » on this link (in French):
http://mirzoune-ciboulette.forumactif.org/t706-vitamine-k2-achat-exemples-de-produits#6433
Info on absorption, target and dosage of vitamin K (and links from Chris Masterjohn and Kate Rheaume-blue) (in French, with English links)
https://mirzoune-ciboulette.forumactif.org/t1704-vit-k-mk4-vs-mk7-update-02-2020#21497
