Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin
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I am dealing with shortness of breath as well as edema in my ankles and my waist that is reminiscent of last year's leadup to heart failure.
This time I know better on what causes it, and am taking things to my own hands rather than defer to the expertise of my cardiologist and my pulmologist. Although I will be forever thankful to my doctors for saving me from death from heart failure, I realize seeing them to solve this repeat issue is only going to lead to the same issue cropping up every now and then, with each time making me weaker. This rinse and repeat cycle only ends with me weaker and closer to death in a slow death spiral common to patients having been confined for heart issues.
I surmised by deductive reasoning that when I used zapper emf frequency to spur my lymphatic system to release dead red bloods that had congested in my lymph, it let loose a mass of RBCs into my lungs. The enzyme heme oxygenase began to produce carbon monoxide and iron from the heme in RBC. Free iron is toxic as well, but I shall concentrate in the interest of brevity on the harm being caused by the carbon monoxide.
The CO (carbon monoxide) causes the lungs to be watery and to restrict breathing. So much so that I experience hardness of breathing, and my spO2 levels would plunge 88, though this sporadic, and values of 75 would occasionally come up. This isn't good.
The doctors would never see this as a CO issue from dead red blood cells. the cardio would give me BP medication to lower BP and diuretics to get rid of water in my lungs. My pulmo would concur.
I did some research on how to deal with CO poisoning, and got a lot of hits, and all of these solutions involve the use of methylene blue at large amounta such as 50mg to 70mg to be taken in one sitting diluted in 100ml water. There is another option, using IV and using less water.
Well and good. But I would wonder why I can't find a protocol using MB for my situation. Further search only got me treatments using oxygen and hyperbaric oxygen. Personally, I think this is inane.They won't work. As how would more oxygen work when the lung is watery and can't take in oxygen in normal amounts.
I've taken lower amounts of mb to see if I could see mb effective at lower doses. But the doses I've taken are really low, just to be safe (although I'm aware that dosing is biphasic and lower doses can make it ineffective or even harmful).
I've done a day at 3 doses of 16mg (40 std drops of 400 mcg) and another at 3 doses of 32mg. Both are no good.
Am thinking of doing at a much higher one time dose of 35mg (which is half of the dose for CO poisoning common for CO inhalation in enclosed garages) and if this doesn't work I'll punch it up to 70mg.
I think 70mg is safe, but thought I'd run this by you guys here.
Incidentally, my case of CO poisoning via heme oxygenase may be more common but never diagnosed. I just happen to stumble upon it when my zapper emf treatment caused this issue. I think anytime the lungs suffer and is congested, the possibility of red blood cells dying en masse can result in the pooling of rbcs that are a ticking time bomb waiting to be released. What about the case of long CoVID also?
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@yerrag said:
As how would more oxygen work when the lung is watery and can't take in oxygen in normal amounts.
Have you looked into uses of molecular hydrogen gas?
Especially within recent years it has shown to be very effective in pulmonary conditions. By reducing the inflammation at the alveoli level the actual gas exchange is re-enabled. I.e., giving O2 in increasing gradients in pulmonary conditions often only increases the stress and doesn't get through to the bloodstream whilst there's more and more water filling the lungs.
The molecular hydrogen however (added to normal air, or as H2+O2, or as Brown's gas from a wet cell catalyst comprising H2+O2+plasma H2) soothes and allows for O2 to get in and CO and whatnot to get out.
I can confirm it increases SpO2 and capillary perfusion within moments. It's also a sort of a nutrient feeding right into these ATP nanomotors (ATP synthase?). And it's somewhat immunoinhibitive to an uncertain practical extent, decreasing NETs and citrullination and by antagonising TLR4 also the beta defensins/innate immunity and of course the ROS by neutralizing the hydroxyl radical (HO) in particular.
Overall the best effects of molecular hydrogen arise not from continuous but from intermittent use.Lymphatic massage manuals or one of those "Chi machines" may be another idea to support lymphatic drainage, along with foot or full body baths with perhaps sodium hydrogen carbonate or hydrogen peroxide (to bring in more oxygen to bind with the CO (which also creates HO radicals so in a way it's an opposite approach to H2)) or magnesium chloride (the chloride for increasing renal excretions).
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Thanks but I don't have a hydrogen machine, though I admit I also am skeptical of hydrogen machines.
Which leaves me with deciding what dosage to use for the mb.After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
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@yerrag said:
After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
The wanted benefits should be felt very quickly, IIRC within 1 hour. If 20mg in the morning works well, maybe 15mg 8hrs later is also already enough. If the 20mg didn't bring any benefits but no bad feelings either, I myself would take try another 20mg already one hour after the first dose.
If up to 1mg/kg bodyweight within a couple of hours brings no relief I'd dimiss it and look elsewhere and keep MB in the cupboard for an acute urgent situation of ischemia.
I think MB is a very powerful and important instrument acutely.
I don't think it generally changes chronic conditions once it's out of the system again (after a few days). I won't take it again without carbs or glucose / on an empty stomach because of the glucose drop.I also just remembered that Methylene Blue as a phenothiazine complexes with B2 and leads to higher excretion so it's important to not become deplete in B2 while "binging" MB. Vitamin B2 also acts as an important redox agent.
@yerrag said:
I don't have a hydrogen machine, though I admit I also am skeptical of hydrogen machines.
That's okay. Maybe careful inhalation of H202 solution (stabilizer-free) could also help the impaired alveoli? Either with a spray bottle or nebulizer or a vaporizer, humidifier for the whole room over night at about max. 1%.
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@CrumblingCookie said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@yerrag said:
After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
The wanted benefits should be felt very quickly, IIRC within 1 hour. If 20mg in the morning works well, maybe 15mg 8hrs later is also already enough. I think MB is a very powerful and important instrument acutely.
Yes. Good thinking.
I don't think it generally changes chronic conditions once it's out of the system again (after a few days). Just don't take it without carbs or glucose / on an empty stomach to avoid a glucose drop.
If the source of carbon monoxide (dead red blood cells worked on by heme oxygenase) is depleted, there would be no chronic condition to deal with.
I also just remembered that Methylene Blue as a phenothiazine complexes with B2 and leads to higher excretion so it's important to not become deplete in B2 while "binging" MB. Vitamin B2 also acts as an important redox agent.
Thanks, I'll increase my B2 intake just to be sure.
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@yerrag said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@CrumblingCookie said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@yerrag said:
After breakfast I'll decide on the dosage I likely would do a 3 x 20mg for the day.
The wanted benefits should be felt very quickly, IIRC within 1 hour. If 20mg in the morning works well, maybe 15mg 8hrs later is also already enough. I think MB is a very powerful and important instrument acutely.
Yes. Good thinking.
I don't think it generally changes chronic conditions once it's out of the system again (after a few days). Just don't take it without carbs or glucose / on an empty stomach to avoid a glucose drop.
If the source of carbon monoxide (dead red blood cells worked on by heme oxygenase) is depleted, there would be no chronic condition to deal with.
I also just remembered that Methylene Blue as a phenothiazine complexes with B2 and leads to higher excretion so it's important to not become deplete in B2 while "binging" MB. Vitamin B2 also acts as an important redox agent.
Thanks, I'll increase my B2 intake just to be sure.
The past two days I have become bloaty and serotogenic and couldn't sleep.
The first day on mb I got the dose right, at 3x16mg. I doubled it the next day to 3x32mb, which was a mistake as 70mb/day was my limit. And I had made a boo boo in my calculations.
Yesterday I felt terrible and ate little. Too much and the medicine becomes the disease itself.
Last night I chewed on a teaspoon of fennel seeds, and I caught some needed sleep, though short as it is.
I hope the meth blue wears out quickly. Will take a few days of rest to recover and the resume my original plan of detoxing the carbon monoxide, which may or may not have exhausted its source of dead read blood cells taking up space in my lymph.
When all is done, the CO will be gone and my breathing not be strained, and the free iron that uses to be in my hemoglobin would be sequestered chelated, and excreted. This will in turn lower my blood pressure.
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@yerrag
Sorry to read that you crashed into excessive MB MAO-inhibition and agitation, anxiety.
3x32mg = 96mg of MB in one day after already 48mg the day before and some the day before is really much.
It'd be easiest if some of the caused anxiety and insomnia were caused by low-BG and some dextrose could help.
I know fresh ginger, ginger juice or oily ginger extract are anti-serotonine at high doses. They'll block CYP3A4, though, so not a sustainable thing to do.Not sure whether your CO hypothesis holds up after a trial with this much MB. Do you think your current extrapolations are becoming too far stretched? Perhaps very limited in their practical extent, even if theoretically true?
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@CrumblingCookie said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
@yerrag
Sorry to read that you crashed into excessive MB MAO-inhibition and agitation, anxiety.
3x32mg = 96mg of MB in one day after already 48mg the day before and some the day before is really much.Yes, two days since the 96mb day I get very hyper that lying down causes a hyper reaction. I'm hoping I could use the Cypro which I manage to find tucked between a nook and cranny. My sis gave me chamomile tea to calm me down
There's always a first time.
It'd be easiest if some of the caused anxiety and insomnia were caused by low-BG and some dextrose could help.
Not with me. My.blood sugar is top notch.
I know fresh ginger, ginger juice or oily ginger extract are anti-serotonine at high doses. They'll block CYP3A4, though, so not a sustainable thing to do.
Thanks. I hope I don't have to use them.
Not sure whether your CO hypothesis holds up after a trial with this much MB. Do you think your current extrapolations are becoming too far stretched? Perhaps very limited in their practical extent, even if theoretically true?
Except for the MB snafu, the theory is sound. It's no coincidence that my breathing became short and my neutrophils and macrophages got so active after I used the zapper with the lymphatics program chosen.
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I think that my struggles with sleeping will never go away unless my lungs are cleared of waterlogging or edema. That the edema is happening in the lungs does not mean it is confined to the lungs, as it can happen in the ankles and in the waist, but it is significant when it happens in the lungs especially that it powers the heart greatly and the lack of oxygen as a substrate has a great deal to do with heart failure.
Moreover, the lungs being waterlogged keeps it from deactivating serotonin, and when this happens, no amount of effort on my part is going to allow me to sleep. Already 3 days in without sleep, I take this issue as my job 1 before anything else.
Last night, I have no choice but to get back to mb treatment. I use s familiar dose at 16mb at midnight and spent the whole night monitoring for changes in spO2. It confirmed that mb did indeed increase my spO2 values greatly, confirming mb as an effective treatment.
However, despite using 3 drops of Cypro, I could not get myself to sleep. This means I have to find an mb dosage and frequency that would eventually result in dry lungs. Dry lungs would ensure serotonin is deactivated by the lungs. Not only can I sleep well, but my heart will pump much better.
Good that I have a tool to see if my lungs are dry- personal ECG that can graphically show a tall QRS wave.
I may be conservative and go with 3 x 16mg mb a day for now, and if I don't see much headway will increase dosage upward.
It's too bad I don't have the benefit of using doctors or even members here with the experience and insight I so need, but I will manage. It has happened to me before, so I am no stranger to it.
Thanks for your comments, advice, and support.
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No sooner than I closed the previous post did I began to question my approach.
Considering I had not slept for 3 days, and that I survived the 3 x 32mg dosing for a day, and that the recommended treatment is a one time intake of 50mg or even 70mg (based on 1mg/kg),
why am I holding off on using a one time dose when it has already been used and recommended?
So, at lunchtime, I will take a 50mg dose, while accounting for the 16mg I tookat midnight.
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I don't know if it will be useful to you (you've already been there and done that), but TonEBP/NFAT5 activation could help deactivating HO-1:
We found that TonEBP is a potent suppressor of HO-1 in human and mouse macrophages.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00850/full
The FXR might help too to rebuild heme:
FXR orchestrates the expression of multiple heme biosynthetic enzymes. Finally, human HepG2 cells and primary human hepatocytes treated with obeticholic acid, showed increased expression of several heme biosynthetic genes.
(In the liver...)
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I took in 50mg in100ml water yesterday in one sitting at 1pm. Gladly, nothing terrible happened. Expert for it causing my urine to trickle and mu urination became negligible. Fecal matter in small amounts.
My appetite was suppressed and desire to drink inhibited.
Because I had taken mb 2 and 3 days before I took this one time dose, I could not tell how different I would feel had I just taken this one-time dose.
But taking it in one dose seems the right way, as the strength seemed to have allowed mb to act as a diuretic, as I started to feel the effect it had on acting to dry the lungs. Still, my bloat remains, and my weight even increased by 3 kg I am hoping the diuretic effect would happen eventually. Will it take as long as a week?
The best part is my hardness of breath is gone, which one would expect when the lungs is drier. But not totally dry, as I could not see confirmation in my ECG's QRS wave, which is still depressed.
Will keep you posted.
Oh yes, I slept well last night. The drier lungs made the lungs get back it's work as a deactivate of serotonin.
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I could have gone at it at 1mg/kg of my bodyweight at 70 mg. Oh well.
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@NNight said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:
I don't know if it will be useful to you (you've already been there and done that), but TonEBP/NFAT5 activation could help deactivating HO-1:
We found that TonEBP is a potent suppressor of HO-1 in human and mouse macrophages.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00850/full
The FXR might help too to rebuild heme:
FXR orchestrates the expression of multiple heme biosynthetic enzymes. Finally, human HepG2 cells and primary human hepatocytes treated with obeticholic acid, showed increased expression of several heme biosynthetic genes.
(In the liver...)
Seems like the directions would be complicated, or materials not easily available. But thanks.
