Why does nitrix oxide decrease with aging?
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3390088/
Egashira et al. [57] reported more dramatic findings in the coronary circulation of aging adults whereby there was a loss of 75% of endothelium-derived nitric oxide in 70-80 year old patients compared to young, healthy 20 year olds.
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@wester130 Endothelium is comprised of eNOS. Young people are expected to have good levels. The detrimental form that is a mediator of stress and directly causes tissue breakdown and inflammation is the inducible iNOS.
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@bio3nergetic thanks
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@DavidPS what's your point?
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@wester130 said in Why does nitrix oxide decrease with aging?:
@DavidPS what's your point?
The title of the thread is focused on "Why" and the image that I posted shows the mechanisms of "How" and the consequences. Sorry for the confusion.
“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541)
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@DavidPS Always a gentleman!
Coincidentally I was looking into Citrulline Malate again, and remembered how Georgi mentioned that elevated levels of NO are carcinogenic and lower metabolism.
Always used to give me an amazing pump in the gym however.
Anyone else have any experience with Citrulline Malate?
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@Ismail you don't want the malate, you want the normal version,
l-citrulline
nitric oxide from watermelon seems helpful though
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Ray Peat's Newsletters
"Some of the obvious changes of aging, such as loss of muscle (Martinez-Moreno, et al., 2007) and gain of fat (Bahadoran, et al., 2015) and decreased sensitivity to insulin (Ropelle, et al., 2013), are produced by increased nitric oxide."
"In people with Parkinson’s disease, increased amounts of iron, nitric oxide, and prostaglandins have been observed."
"a diabetes-like state is created by nitric oxide damage, forcing the use of fatty acids instead of glucose for fuel."
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@Gardner did he differentiate between iNOS and eNOS?
