How to lower Adrenaline
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@BlueMeth Are you speaking to me? I'll assume yes.
Cypro: I've been there and done that. I took a tiny bit (1 drop, 2? I've slept since then). Anyhow, the next morning 9:00-9:30 am, I was so loopy I couldn't function. So I researched it.
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"Do not use cyproheptadine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine."What does an MAO inhibitor do?
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"Monoamine oxidase inhibitors are responsible for blocking the monoamine oxidase enzyme. The monoamine oxidase enzyme breaks down different types of neurotransmitters from the brain: norepinephrine, serotonin, dopamine, and tyramine. MAOIs inhibit the breakdown of these neurotransmitters thus, increasing their levels and allowing them to continue to influence the cells that have been affected by depression.[6]"I believe that I reacted badly to Cyproheptadine because I had a thiamine deficiency which resulted in serotonin build up in my brain synapses. In other words, the thiamine deficiency caused the same issue as an mao inhibitor.
additionally:
About Methylene Blue:
Methylene blue increases the risk of serotonin toxicity.also this one: https://www.apsf.org/article/methylene-blue-and-the-risk-of-serotonin-toxicity/
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"Serotonin toxicity is a result of inappropriately high levels of synaptic serotonin and its severity directly relates to the concentration of serotonin (5-HT) in the synaptic spaces in nervous tissue. Both serotonin releasers like methamphetamine and serotonin reuptake inhibitors (SRIs) have the potential to induce severe serotonin toxicity when administered with MAO inhibitors. Selective and non-selective serotonin reuptake inhibitors increase serotonin by preventing its clearance from the intraneuronal synaptic space. MAO inhibitors prevent intraneuronal metabolism of serotonin, leading to increased release of serotonin from neurons. SRIs by themselves, even if taken in overdose, do not usually precipitate the severe form of serotonin toxicity. However, normal therapeutic SRI doses along with even a single dose of an MAOI like methylene blue may lead to serotonin toxicity as a result of the combination of increased 5-HT release and reduced synaptic 5-HT clearance.9"
-end paste-Thiamine is needed to clear serotonin from the brain synapses. I was living with a thiamine deficiency for a very long time (decades). My brain serotonin was very high because of this. I wasn't taking ssri's but my serotonin was so high that I was unable to tolerate serotonergic foods like bananas and pineapple. The addition of a tiny dose of methylene blue was toxic to my system. It made me feel pretty awful.
I've recovered from the problem I had with brain serotonin overload via taking thiamine hcl. I am now able to enjoy the occasional banana without issue whereas before I could not.
So thanks anyway but I'll pass on the cypro (and the methylene blue too) and I'll stick with the thiamine hcl (and the magnesium glycinate).
Here's an article for your consideration:
https://www.hormonesmatter.com/serotonin-syndrome-thiamine-connection/ -
Agree with what's already mentioned about salt. Having a teaspoon of salt in some water, making sure it's properly dissolved, has been the most potent thing for immediate results for me.
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@mostlylurking I remember from the RP Forum that you're a huge fan of thiamine and convinced that thiamine deficiency is behind most people's problems. I'm not so sure about that. The list of symptoms of thiamine deficiency is basically every symptom under the sun, and I know that Ray Peat was never terribly convinced that thiamine was the be all and end all. I asked him about it once and he said it's most likely hypothyroidism. He advocated for dosages between 10-100 mg a day. There is a very long list of people who believed they had beri beri and started taking high dose thiamine and experienced nothing but misery and a host of new problems, which I know the thiamine cheerleaders simply call "the paradoxical reaction" (or something to do with methylation or not having the right co-factors etc), but it never went away and they had to give up. They're in a facebook group and it's depressing reading. Do me a favour mate and PLEASE don't spam every thread on this new forum with the beri beri guff!
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And FWIW, cypro is known to make people feel loopy, sluggish etc in the beginning. It's an almost universal reaction, and it passes when the body adjusts. Given how heavily impacted by excess serotonin you seem to have been, I wouldn't write cypro off based on one standalone experiment. Cypro acts on serotonin like nothing else, and as a result, a host of other down river symptoms given what a master manipulator serotonin is.
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@BlueMeth Thanks for sharing.
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@A-Former-User said in How to lower Adrenaline:
I remember from the RP Forum that you're a huge fan of thiamine and convinced that thiamine deficiency is behind most people's problems. I'm not so sure about that. The list of symptoms of thiamine deficiency is basically every symptom under the sun, and I know that Ray Peat was never terribly convinced that thiamine was the be all and end all. I asked him about it once and he said it's most likely hypothyroidism. He advocated for dosages between 10-100 mg a day. There is a very long list of people who believed they had beri beri and started taking high dose thiamine and experienced nothing but misery and a host of new problems, which I know the thiamine cheerleaders simply call "the paradoxical reaction" (or something to do with methylation or not having the right co-factors etc), but it never went away and they had to give up. They're in a facebook group and it's depressing reading. Do me a favour mate and PLEASE don't spam every thread on this new forum with the beri beri guff!
I should just ignore you because you are being a first class jerk. But I've decided to respond instead.
#1: Ray Peat recommended thiamine quite a lot actually; he just never wrote a full article about it. Here are a few links for your consideration:
Thiamine mentioned in Ray Peat's written work
Vitamin B1 (thiamine) mentioned in Ray Peat's written work
Thiamine mentioned in Ray Peat's audio interviews
Vitamin B1 (thiamine) mentioned in Ray Peat's audio interviews
#2 This forum is named the Bioenergetic Forum for a reason.
https://www.nature.com/subjects/bioenergetics
"Bioenergetics is the branch of biochemistry that focuses on how cells transform energy, often by producing, storing or consuming adenosine triphosphate (ATP). Bioenergetic processes, such as cellular respiration or photosynthesis, are essential to most aspects of cellular metabolism, therefore to life itself."Ray Peat focused a lot on the concept that if cellular energy is optimized then health follows.
It will probably come as a shock for you to learn that thiamine is required for cellular energy. Thiamine acts as a co-enzyme in several steps in the Krebs cycle which is how cellular energy (ATP) happens.
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