Low dose Test?
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Are we not doing test (in small, peaty doses with vit e, to reduce potential for aromatization) because we think it will compromise endogenous production after cessation of the exogenous? We seem all quite confident that the thyroid gland resumes endogenous production post cessation of exogenous supplementation - is there any reason to think the gonads would be different?
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@Cristiano said in Low dose Test?:
Are we not doing test (in small, peaty doses with vit e, to reduce potential for aromatization) because we think it will compromise endogenous production after cessation of the exogenous? We seem all quite confident that the thyroid gland resumes endogenous production post cessation of exogenous supplementation - is there any reason to think the gonads would be different?
Odpowiedz
Administration of exogenous testosterone may lead to inhibition of the hypothalamic-pituitary-testicular (HPG) axis, which results from a feedback mechanism. When testosterone levels in the blood increase, the hypothalamus and pituitary gland reduce the production of hormones that regulate testicular function (LH and FSH), which can lead to a reduction in the natural production of testosterone by the testicles.
In the case of the thyroid gland, thyroid hormone supplementation (e.g. levothyroxine) also affects the hypothalamic-pituitary-thyroid axis, but the mechanisms are slightly different. After discontinuation of exogenous thyroid hormone supplementation, normal thyroid function usually returns, unless there is damage to the gland or other permanent pathological changes.
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@Fructose thanks gpt...
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@Cristiano said in Low dose Test?:
gpt...
I don't use AI. I just try to inform about such things transparently.
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Well, I'm not sure that's really accurate.
There is lots of evidence that the hippocamal neurons responsible for producing GnRH do not really have a negative feedback loop with the endogenous endpoint androgens (DHT, T) themselves per se, but rather with estrogen.
When introducing anabolic compounds with inherent estrogenicity such as nandrolone, they probably have their own negative HPTA feedback, but it does not appear to be the case with testosterone itself.
That is why steroidal AIs such as exemestane (Aromasin) work. They reduce the conversion of testosterone to estrogen thus removing the negative feedback that estrogen has with the HPTA.
If you were right about testosterone having a negative feedback, then there would be no way that exemestane would work. But it does.
You could try taking testosterone powder either in milk at around 30mg/day with around 200mg P5 together with an AI such as androsterone and see if you get "shut down" (I don't think you will
In time there is life but no knowledge; outside time there is knowledge but no life
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@jamezb46 Could you use 6-Keto-P4 in place of the P5? Have you tried this stack yourself? Could DHT be added to the stack and at what ratios?
The earth speaks to us all, Just listen
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@Sugarnotsnow
The P5 comes from a study @haidut posted on the RP forum.
I think anything that opposes estrogen either at the receptor or by inhibiting aromatase would work. Whether 6 keto p4 would work is anyone’s guess.
Why do you want to use DHT? Just use T + Androsterone.
I am in the process of making my own T in vitamin E at 10% concentration so stay tuned for the results. Plan is to take around 25 mg per day combined with androsterone as needed for estrogen management ( I doubt I’ll need this - I’m fairly lean and muscular) and possible with pansterone. I’ll post when I have some data to report back on from that experiment
In time there is life but no knowledge; outside time there is knowledge but no life
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@jamezb46 Ive used DHT and had good experience with it. Never used androsterone. Would they both play a similar role in this stack as an AI?
The earth speaks to us all, Just listen
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@Sugarnotsnow
Yes, both DHT and Androsterone are AIs. From peoples experience in the Forum, androsterone is a fairly potent one.
In time there is life but no knowledge; outside time there is knowledge but no life
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@jamezb46 Okay thank you. Do you take both of them every day? Or cycle on and off?
