Diclofenac gel to regrow hair on bald head and beard
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strangely, Frankincense is one of the highest rated anti-fibrotic agents that can stop TGFb-1
maybe an alcohol tincture of it used topically, but you would smell like a christmas tree
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@wester130 said in Diclofenac gel to regrow hair on bald head and beard:
...but you would smell like a christmas tree
There are much worse things to smell like
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top 20 anti fibrotics
- Pirfenidone - 100%
- Nintedanib - 98%
- Nerandomilast - 96%
- Losartan - 90%
- Spironolactone - 85%
- Rapamycin (Sirolimus) - 82%
- Curcumin (high-bioavailability forms) - 75%
- Gotu Kola (Centella asiatica standardized extract) - 74%
- Frankincense/Boswellia (standardized) - 72%
- Pentoxifylline - 70%
- Berberine - 68%
- Resveratrol - 65%
- Quercetin - 60%
- EGCG (Epigallocatechin gallate) - 58%
- Silymarin (Milk Thistle) - 55%
- Colchicine - 52%
- Metformin - 48%
- N-Acetylcysteine (NAC) - 45%
- Sulforaphane - 42%
- Apigenin - 40%
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These are the best things for hyperkeratinization
Urea
Lactic Acid
Glycolic Acid
Salicylic Acid
Retinol/Retinoids
Centella Asiatica (Cica/Madecassoside)
Niacinamide
Ceramides
Hyaluronic Acid
Vitamin C
Peptides (e.g., copper or Matrixyl)
Azelaic Acid
Bakuchiol
Polyhydroxy Acids (e.g., gluconolactone)
Ammonium LactateWhat is the body reacting to? The first inflammation seen in Androgenetic Alopecia is in the upper infradfulindulum where hyperkeratinization is usually taking place. There are 5AR type one there and androgen receptors there. I see two possibilities: either DKK_1 downstream of the papilla is killing keratinocytes or hyperkeratinization from too much androgen stimulation is killing the keratinocytes and the dead keratinocyte cells still in the hair shaft that have not grown all the way out of the body are eliciting the immunological response. The inflammaition in Androgenetic Alopecia is in the upper one third of the follicle, not down in the papilla where you think it would be. Inflammation, as Harold pointed out, is like a bomb going off in the body. Tissues next to the effected tissue get hurt also. This is my opinion of course, but cannot figure out any other reason why the damge in androgenic alopeica is a "low" process. Classic autoimmune disorders see the effected tissue destroyed pretty damned fast (just a few years at most), not over a decade or two like men slowly balding with too much collagen secreted all around the organ as happens. Docj077 thought TGF beta was the primary culprit in baldness------I wish he still posted, he was bright.
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@wester130 that was interesting, and something that always rings an alarm for me is when it aligns with something Peat had mentioned. In this case I couldn’t help but think of the story of the man who regrew his hair when he fell in the fireplace and burned his scalp. I mean all he did was essentially give himself a very painful peel right?
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@evan.hinkle removing the old collagen can be helpful, yes, by forcing fresher collagen to be produced
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retinol only for hair growth??? maybe it is a collagen problem
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@wester130 retinol also supposedly has a role in thyroid transport (I think t3)
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@wester130 I forget the exact time period — maybe 7-10 years ago — there was a time when people were putting Retin-A on their scalps for potential hair growth. Retin-A is just what it sounds like, used by dermatologists to recondition skin. Back when I read about it, to my layman's mind, I assumed the Retin-A was just working similarly to salicylic acid, reconditioning the scalp, which was very popular in the hair loss community for a while; but maybe there was something to the vitamin A itself, not just the resurfacing.
For what it's worth, I feel like food based vitamin A, via liver, is one of the best Peaty things yet for me. I definitively feel noticeably better on it, with no side effects. I've just been thinking about this recently, about attempting to consume more liver for more vitamin A. They say your body craves what it needs.
