Diclofenac gel to regrow hair on bald head and beard

wester130

strangely, Frankincense is one of the highest rated anti-fibrotic agents that can stop TGFb-1

maybe an alcohol tincture of it used topically, but you would smell like a christmas tree

Mossy

@wester130 said in Diclofenac gel to regrow hair on bald head and beard:

...but you would smell like a christmas tree

There are much worse things to smell like

wester130

top 20 anti fibrotics

Pirfenidone - 100%
Nintedanib - 98%
Nerandomilast - 96%
Losartan - 90%
Spironolactone - 85%
Rapamycin (Sirolimus) - 82%
Curcumin (high-bioavailability forms) - 75%
Gotu Kola (Centella asiatica standardized extract) - 74%
Frankincense/Boswellia (standardized) - 72%
Pentoxifylline - 70%
Berberine - 68%
Resveratrol - 65%
Quercetin - 60%
EGCG (Epigallocatechin gallate) - 58%
Silymarin (Milk Thistle) - 55%
Colchicine - 52%
Metformin - 48%
N-Acetylcysteine (NAC) - 45%
Sulforaphane - 42%
Apigenin - 40%

wester130

These are the best things for hyperkeratinization

Urea
Lactic Acid
Glycolic Acid
Salicylic Acid
Retinol/Retinoids
Centella Asiatica (Cica/Madecassoside)
Niacinamide
Ceramides
Hyaluronic Acid
Vitamin C
Peptides (e.g., copper or Matrixyl)
Azelaic Acid
Bakuchiol
Polyhydroxy Acids (e.g., gluconolactone)
Ammonium Lactate

What is the body reacting to? The first inflammation seen in Androgenetic Alopecia is in the upper infradfulindulum where hyperkeratinization is usually taking place. There are 5AR type one there and androgen receptors there. I see two possibilities: either DKK_1 downstream of the papilla is killing keratinocytes or hyperkeratinization from too much androgen stimulation is killing the keratinocytes and the dead keratinocyte cells still in the hair shaft that have not grown all the way out of the body are eliciting the immunological response. The inflammaition in Androgenetic Alopecia is in the upper one third of the follicle, not down in the papilla where you think it would be. Inflammation, as Harold pointed out, is like a bomb going off in the body. Tissues next to the effected tissue get hurt also. This is my opinion of course, but cannot figure out any other reason why the damge in androgenic alopeica is a "low" process. Classic autoimmune disorders see the effected tissue destroyed pretty damned fast (just a few years at most), not over a decade or two like men slowly balding with too much collagen secreted all around the organ as happens. Docj077 thought TGF beta was the primary culprit in baldness------I wish he still posted, he was bright.

wester130

this is interesting

https://immortalhair.forumotion.com/t9447-scalp-peeling-with-20-glycolic-acid-great-results

evan.hinkle

@wester130 that was interesting, and something that always rings an alarm for me is when it aligns with something Peat had mentioned. In this case I couldn’t help but think of the story of the man who regrew his hair when he fell in the fireplace and burned his scalp. I mean all he did was essentially give himself a very painful peel right?

wester130

@evan.hinkle removing the old collagen can be helpful, yes, by forcing fresher collagen to be produced

wester130

retinol only for hair growth??? maybe it is a collagen problem

https://pubmed.ncbi.nlm.nih.gov/3771854/

LetTheRedeemed

@wester130 retinol also supposedly has a role in thyroid transport (I think t3)

Mossy

@wester130 I forget the exact time period — maybe 7-10 years ago — there was a time when people were putting Retin-A on their scalps for potential hair growth. Retin-A is just what it sounds like, used by dermatologists to recondition skin. Back when I read about it, to my layman's mind, I assumed the Retin-A was just working similarly to salicylic acid, reconditioning the scalp, which was very popular in the hair loss community for a while; but maybe there was something to the vitamin A itself, not just the resurfacing.

For what it's worth, I feel like food based vitamin A, via liver, is one of the best Peaty things yet for me. I definitively feel noticeably better on it, with no side effects. I've just been thinking about this recently, about attempting to consume more liver for more vitamin A. They say your body craves what it needs.

wester130

@Mossy many companies are mixing Minoxidil with treitinoin, so it is positively affecting the collagen

i am not sure of what mechanism, maybe inflammation, maybe improving collagen,

Hearthfire

@wester130

I think treitinoin helps absorption, but also:

Chat GPT says:

Tretinoin (a retinoid) increases skin cell turnover and thins the outermost layer of the skin (stratum corneum), which can:
Increase scalp permeability
Allow more minoxidil to reach the follicles

Minoxidil must be converted into minoxidil sulfate by an enzyme in the scalp called sulfotransferase.
Some research suggests tretinoin may:
Increase sulfotransferase activity

Some peoples scalps don't have enough sulfotransferase, therefore treitinoin is used topically to convert it.

Alternatively, oral minoxdil can be taken if you're a non-responder to topical, because the liver has abundant sulfotransferase enzymes.

wester130

"In reference to the man who fell in a fireplace and regrew his hair - you can actually get your scalp skin burned off.
It is called a phenol peel, far stronger than an ordinary chemical peel.
It is not sold online, you cannot buy the ingredients, only specialist beauty centers will offer it."

wester130

has anyone ever considered scar gels for hair loss?

there is a lot of overlap with healing the skin and TGFb-1

many of them contain interesting ingredients that would stop inflammation in the scalp

LetTheRedeemed

@wester130 going down the turpentine rabit hole, I googled around and found some research on terpenes supposedly reducing types 1 and 3 collagen -- bakuchiol, according to google. this also said terpenes are used for wound healing. I'm willing to believe that turpentine can straight up strip the collagenous paint out of one's scalp, lol

part of me wants to put turpentine on my head.

LetTheRedeemed

@wester130 oh wow, ultrasound can break down fibrous tissue at the cellular level. There are clinics offering therapeutic scalp ultrasounds for hair health. https://onlinelibrary.wiley.com/doi/abs/10.1002/tee.23866

wester130

some research i am doing on essential oils and vasodilation

rosemary and menthol are not potent, neither is euclayptus, neither make the top 10

patchouliguaiols ,
citral,
carvacrol + thymol ,
eugenol
are the most potent vasodilators if you are looking at isolated chemicals

for patchouliguaiols, spikenard or simply patchouli oil would work

for citral, lemongrass or lemon verbena

for carvacrol + thymol , - oregano and thyme

for eugenol - clove essential oil would work

ginger, cinnamon, capscium, rosemary, menthol don't make the top 10 list.
rosemary for hair is the biggest scam going, look at the science, the chemicals in rosemary do not vasdodilate,

Gaston

@wester130 More horseshit from Big Rosemary.

CrumblingCookie

Rosemary (or sage) is not about vasodilation but about powerful anti-inflammatory activity by its diterpene carnosic acid, which is an antagonist to the human VDR and thus innate immunity. It may therefore work topically (to suppress symptoms for temporary healing but not to cure) for psoriasis and the like.

Hearthfire

@CrumblingCookie

It also kills bacteria and fungus and parasites (e.g. demodex mites). The vasodilation was never the main use for me.

And who cares if it's not the most potent vasodilator? It still produces some vasodilation. That's just a plus.

Anti-inflammatory + anti-bacteria/fungus/parasite + vasodilation. No way that's not going to be beneficial to your hair health/growth.