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    Random, interesting studies

    Literature Review
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    • cs3000C
      cs3000 @Mauritio
      last edited by cs3000

      @Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
      as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)

      "world," as a source of new perceptions
      more https://substack.com/@cs3001

      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

      MauritioM alfredoolivasA 2 Replies Last reply Reply Quote 0
      • MauritioM
        Mauritio @cs3000
        last edited by

        @cs3000 Oh damn so close and yet so far 😄
        Do you have a source for it beeing indigestible for us ?

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        R cs3000C 2 Replies Last reply Reply Quote 0
        • MauritioM
          Mauritio
          last edited by Mauritio

          For those saying DNP is safe and only careless people die from it.

          https://www.ergo-log.com/safe-dnp-cycle-fatal-outcome.html

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          1 Reply Last reply Reply Quote 0
          • MauritioM
            Mauritio
            last edited by

            "This study concludes that the dietary recommendation to avoid consuming coconut oil due to its effects on lipid parameters is not justified,"

            https://www.ergo-log.com/coconut-oil-blood-vessels.html

            Dare to think.

            My X:
            x.com/Metabolicmonstr

            1 Reply Last reply Reply Quote 0
            • R
              random @Mauritio
              last edited by random

              @Mauritio said in Random, interesting studies:

              @cs3000 Oh damn so close and yet so far 😄
              Do you have a source for it beeing indigestible for us ?

              @Mauritio @cs3000 i have eaten honey comb multiples Times, a good part of the wax do not melt in the mouth even if you chew it very long, and the part that you swallow often end up as solid flakes in your intestins that cause intestinal irritations and nightmare if you swallow alot. Comb from more recent hives and recently harvested Can be much softer. If you look at hunters gatherers eating honey comb in documentary they spit back the comb. part of beekeepers use plastic/synthetic materials as a base for bees to build the hive on, therefore some honey comb contain a sheet of plastic/synthetic materials in the middle. It is possible you absorb part of what is in the wax, as wax that is colored like orange will end up white/yellowish if you chew it alot even if you dont swallow it

              1 Reply Last reply Reply Quote 2
              • cs3000C
                cs3000 @Mauritio
                last edited by cs3000

                @Mauritio
                one in dogs vs birds (fig 2 , its not policosanol tho general
                fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestion

                but looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
                but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
                https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02
                8e3275d1-bf2b-4741-b064-61a37927c3a5-image.png
                was still worth posting your post now i know more about it & wouldnt have

                @Mauritio said in Random, interesting studies:

                for it beeing indigestible for us ?

                👍 🐝

                study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/

                "world," as a source of new perceptions
                more https://substack.com/@cs3001

                "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                cs3000C MauritioM 2 Replies Last reply Reply Quote 0
                • cs3000C
                  cs3000 @cs3000
                  last edited by

                  @cs3000 if its extracted from sugarcane wax its mostly the free form policosanol with high % octacosanol and more digestible https://pubmed.ncbi.nlm.nih.gov/12423895/ maybe 7% as esters in the wax. has b-sitosterol which is anti androgen but <1% of the wax

                  "world," as a source of new perceptions
                  more https://substack.com/@cs3001

                  "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                  1 Reply Last reply Reply Quote 0
                  • alfredoolivasA
                    alfredoolivas @cs3000
                    last edited by

                    @cs3000 said in Random, interesting studies:

                    @Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
                    as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)

                    Doesn’t the hot water cause hydrolysis ?

                    cs3000C 1 Reply Last reply Reply Quote 0
                    • MauritioM
                      Mauritio
                      last edited by Mauritio

                      Anybody tried bees bread ?

                      In this study it did wonders for steroid health.
                      They gave mice on a HFD about 5-7g(HED) of bees bread and it completely rescued the levels of their steroidogenic enzymes.
                      Not only that, in many cases, giving them bees bread, increased the values above the normal control group.

                      Testosterone was increased by about 60% above control levels.
                      StaR mRNA levels doubled !
                      Unfortunately estrogen was increased as well, but only to the level of the control group not above that.

                      1000014499.jpg

                      https://journals.physiology.org/doi/full/10.1152/ajpendo.00093.2021?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

                      R L MauritioM 3 Replies Last reply Reply Quote 0
                      • R
                        random @Mauritio
                        last edited by random

                        @Mauritio said in Random, interesting studies:

                        Anybody tried bees bread ?

                        I did, it Can taste much better than basic honey comb that has only wax and honey, basic honey comb is often to acidic and taste aint the best in most case compare to some honey in jar and some beesbread

                        1 Reply Last reply Reply Quote 0
                        • L
                          lobotomize-me @Mauritio
                          last edited by lobotomize-me

                          @Mauritio honey /most bee products /chyrsin rich foods generally increase testosterone.

                          1 Reply Last reply Reply Quote 1
                          • cs3000C
                            cs3000 @alfredoolivas
                            last edited by cs3000

                            @alfredoolivas said in Random, interesting studies:

                            Doesn’t the hot water cause hydrolysis ?

                            apparently too slow by itself so they do extra processing

                            @Mauritio said in Random, interesting studies:

                            Anybody tried bees bread ?
                            In this study it did wonders for steroid health.

                            nice , & a potent effect really fast in a diabetes model. normalised by 3 days. fastest effect ive seen
                            STZ model = destruction of pancreas cells so i guess its most relevant to type 1 , or if someone with type 2 has lacking pancreatic islet cells too as part of their problem. full damage was done initially so shows good effect
                            f7a91ad7-462d-47b0-a878-76e754978cba-image.png
                            they used an extract ~30mg polyphenols 5mg flavanols per gram so maybe ~ 5g bee bread for 1g of extract
                            composition varies a lot by location if it was the polyphenols giving most of the effect even in same country by region,
                            theirs was high in kaempferol-3-O-di-rhamnoside Isorhamnetin-O-hexosyl-O-rutinoside

                            https://pmc.ncbi.nlm.nih.gov/articles/PMC8264221/#sec7

                            and if you believe the results,
                            they showed its acute effect (didnt lower blood sugar when not elevated)
                            540f89e2-7c50-4a14-9207-30b64b1762b7-image.png
                            Which is odd. because its not lowering glucose in non diabetic rats so its not acting like insulin right? unless things are effectively counteracting it in the normal group because it would be crashing otherwise from insulin secretion. (at 3hrs in the DW group they had lower blood sugar though 84 vs 92)
                            unlikely enough islet cells left from the damage to stimulate insulin secretion for such a drastic change in both of the groups, which is what GLB doe? idk maybe there is but they're clearly wrecked from such high glucose at 0hr. 3 hours isnt enough time to regenerate the islet cell damage

                            "world," as a source of new perceptions
                            more https://substack.com/@cs3001

                            "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                            alfredoolivasA 1 Reply Last reply Reply Quote 0
                            • alfredoolivasA
                              alfredoolivas @cs3000
                              last edited by

                              @cs3000 said in Random, interesting studies:

                              apparently too slow by itself so they do extra processing

                              Could I finely dice it up and put it in a pot of boiling water for 15 minutes, whilst it remains boiling for the entire 15 minutes? would that be effective?

                              cs3000C 1 Reply Last reply Reply Quote 0
                              • cs3000C
                                cs3000 @alfredoolivas
                                last edited by cs3000

                                @alfredoolivas i'd guess it takes a lot longer still but not sure ,
                                if youre interested in it for the octacosanol sugarcane wax is better only need a little already in a good form https://bioenergetic.forum/post/47406 supplements are around tho

                                "world," as a source of new perceptions
                                more https://substack.com/@cs3001

                                "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                                C 1 Reply Last reply Reply Quote 1
                                • MauritioM
                                  Mauritio
                                  last edited by Mauritio

                                  Again, TLR 4 /Endo­toxin implicated inInfections, not just bac­terial ones, but also viral.

                                  "TLR4-dependent viral entry was further validated by an anti-TLR4 antibody-mediated blocking experiment. It was noticed that TLR4 is necessary for the early events of viral infection, especially during the attachment and entry stages."

                                  https://pmc.ncbi.nlm.nih.gov/articles/PMC10157217/

                                  Endotoxin might not just be implicated in viral entry, but long term consequences of viruses .
                                  The drug larazotide is being researched for long covid symptoms. It basically works in a way that it prevents endotoxin from entering circulation .

                                  https://ichgcp.net/de/clinical-trials-registry/NCT05747534

                                  Dare to think.

                                  My X:
                                  x.com/Metabolicmonstr

                                  1 Reply Last reply Reply Quote 0
                                  • MauritioM
                                    Mauritio @cs3000
                                    last edited by

                                    @cs3000 said in Random, interesting studies:

                                    @Mauritio
                                    one in dogs vs birds (fig 2 , its not policosanol tho general
                                    fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestion

                                    but looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
                                    but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
                                    https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02
                                    8e3275d1-bf2b-4741-b064-61a37927c3a5-image.png
                                    was still worth posting your post now i know more about it & wouldnt have

                                    @Mauritio said in Random, interesting studies:

                                    for it beeing indigestible for us ?

                                    👍 🐝

                                    study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/

                                    Seems right. For some reason birds seem to be good at it. Humans not. Such a shame.

                                    And interesting studies you posted on Bee bread. Quite the strong effect indeed.

                                    Dare to think.

                                    My X:
                                    x.com/Metabolicmonstr

                                    1 Reply Last reply Reply Quote 0
                                    • MauritioM
                                      Mauritio
                                      last edited by Mauritio

                                      Im not convinced that low protein is dangerous and catabolic, mid - long term in people under 65.

                                      I recently posted a study showing 5 weeks of 8% protein in the diet did not cause muscle loss. After which someone said that isnt long enough .

                                      Now here's a study showing that 12 weeks of a very low 0.4g/kg/d, ~5%protein diet does not lower basal muscle protein synthesis!
                                      https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137183

                                      It seems to come down to age as well.
                                      Here it gets interesting: if you're under 65 and eating a high protein diet, that is strongly associated with death, cancer and diabetes . Over 65 it seems to be protective !

                                      "...aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality..."
                                      https://pmc.ncbi.nlm.nih.gov/articles/PMC3988204/

                                      Not sure why. Low protein diets can lead to lower thymus weight, as seen in this study (https://www.scielo.br/j/bjmbr/a/MGBdr7CsJTMQrf7Bhjbdv3z/?lang=en)
                                      And older people are more susceptible to infections and chronic inflammation .So maybe after 65 the increase
                                      in Protein and inflammatory amino acids is worth the trade off, for increased immunity and suppression of inflammation .
                                      Maybe it's simply the lesser of 2 evils at that point .
                                      What do you guys think?

                                      Dare to think.

                                      My X:
                                      x.com/Metabolicmonstr

                                      LucHL DavidPSD alfredoolivasA 3 Replies Last reply Reply Quote 1
                                      • LucHL
                                        LucH @Mauritio
                                        last edited by

                                        @Mauritio said in Random, interesting studies:

                                        What do you guys think?

                                        After 60 yrs, 2 - 5% % loss is usual, according to activity.
                                        Main causes to fight against (things happening in our bodies as we age that might contribute to sarcopenia):
                                        Reduction in nerve cells responsible for sending signals from the brain to the muscles to start movement.
                                        Lower concentrations of some hormones, including growth hormone, testosterone, and insulin-like growth factor
                                        Increases in inflammation, partly due to disease
                                        A decrease in the ability to turn protein into energy.

                                        So, if we can slow down these processes, we could better manage ...
                                        Law of nature: if not able to reproduce, if not able to transmit knowledge, we become a weight for society.
                                        Note I don't feel it that way 😉

                                        1 Reply Last reply Reply Quote 1
                                        • DavidPSD
                                          DavidPS @Mauritio
                                          last edited by DavidPS

                                          @Mauritio - I am wary of drawing conclusions from studies that lump people into groups based solely on their protein intake. It is too broad-brush for me. For example, is it the high protein or the skewed calcium to phosphorous ratio in the high protein group? Is it the high protein or the change in the glycine to methionine ratio?

                                          Aging is complex. For a more holistic approach, see Ray Peat's 2015 newsletter:

                                          https://wiki.chadnet.org/files/imprinting-and-aging.pdf

                                          ““Effective health care depends on self-care” - Ivan Illich, 👀
                                          ☂️

                                          MauritioM 1 Reply Last reply Reply Quote 1
                                          • alfredoolivasA
                                            alfredoolivas @Mauritio
                                            last edited by

                                            @Mauritio 64938ff9-2fa5-46b7-beba-7447749fa327-image.png
                                            In the first study, the 5% protein diet, caused 0.32% loss in free fat mass.

                                            Which is almost nothing right? very interesting.

                                            MauritioM 1 Reply Last reply Reply Quote 0
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