Random, interesting studies

cedric

@Mauritio
From Wikipedia, the free encyclopedia
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.[1][2]

Relative to their phytoestrogen counterparts, phytoprogestogens are rare.[1] However, a number have been identified, including kaempferol, diosgenin (found in yam), apigenin (found in chasteberry),[1][3] naringenin, and syringic acid, among others.[2] In addition, 3,8-dihydrodiligustilide from Ligusticum chuanxiong is a potent progestogen (EC50 = 90 nM), whereas riligustilide is a weak progestogen (EC50 ≈ 81 μM).[4][5]

carrot salad by R.Peat delivers apigenin (phytoprogestogen) and absorbs estrogens
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full
" In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+-consuming glycoprotein CD38."
Progesteron synthesis depends on NAD as a cofactor as well as myo-inositol synthase .

Mauritio

@cedric said in Random, interesting studies:

From Wikipedia, the free encyclopedia
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.[1][2]

Yes I have posted this very paragraph in this thread before. Not sure how strong Diosgenins progestogenic effects are, it feels more androgenic.

I have posted about syringic acid and the Chinese herb progestogen as well.

Mossy

@dapose Good idea. I'll add this to my planned garden as a medicinal herb. @luch recommends this to calm the gut, and for anti-stress, vagus nerve support.

Mauritio

@Mossy I really liked the effects it did worsen sleep though.

dapose

@Mauritio @mossy i had a cup of lemon balm tea after lunch yesterday and it was very calming, similar to chamomile but not sleepy-calm. My guess is that lemon balm is better for day time stress, and chamomile better for after dinner nighty night time! 🫖

Mauritio

Vitamin K2 Protects Against Glucocorticoid-Induced Osteoporosis by Activating the NRF2/FSP1 Pathway to Inhibit Osteoblast Ferroptosis

https://pubmed.ncbi.nlm.nih.gov/41458254/

Mauritio

Possible plan serotonin antagonists on 5HT3:

'Many constituents, such as gingerol, galanolactone, citronellol, geraniol, CBD, THC, eugenol, and vanillin, are reported to inhibit nausea and vomiting due to their 5-HT3R antagonism."

https://pmc.ncbi.nlm.nih.gov/articles/PMC11184608/#sec10

Mauritio

Cysteine Sulfoxides(from onions) ehance progesterone production in vitro.

https://pubmed.ncbi.nlm.nih.gov/33066465/

Mossy

@Mauritio Thank you. As someone who is hyper sensitive to most things, that's good to know.

Mossy

@dapose Interesting. Good to know. Thank you.

lobotomize

@Mauritio shogaol is easily made from ginger powder you just put it in the oven with some acid dry it out for 60 minutes and it is usually a lot more beneficial than gingerol in 99% of cases

Mauritio

@lobotomize thanks. i use ginger candy or chocolate and IIIRC the ginger in there should be heated is probably already converted to shoal.

Mauritio

@Mossy another Peater said the same thing. So I don't seem to be the only one.
It's exceptional for colds/ flue, but somehow messes with sleep. Maybe GABA rebound effect ?