Random, interesting studies
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@alfredoolivas
Nice catch, this might be important. So it's actually something in the seeds, not the laxative effect.Just saw you can also buy Chia seeds as powder.
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Plant Pregnenolone
The Malaysian plant Holarrhena curtisii contains actual pregnenolone. Its properties also sound somewhat anti-serotonergic.
It also contains alkaloids with steroidal activity
https://pubmed.ncbi.nlm.nih.gov/9834146/
Another alkaloid from the same genus can convert into Pregnenolone in vivo
https://www.researchgate.net/publication/248216582_In_vivo_conversion_of_a_steroidal_alkaloid_holaphyllamine_to_pregnenolone
This paper shows that plants con convert steroids into each other and contain different ratios of known steroids.
Digitalis grandiflora for example contains pregnenolone, progesterone, 17α-hydroxypregnenolone, DHEA, and testosterone
https://pure.mpg.de/rest/items/item_3524574_6/component/file_3528676/content
Holarrhena pubescens another plant from the same genus has anti malarial effects, which rely on the pregnene-type steroidal alkaloids
https://pubmed.ncbi.nlm.nih.gov/29172699/Interesting effects of Holarrhena pubescens on diabetes, also anti-microbial and anti-inflammatory
https://www.mdpi.com/2218-273X/10/9/1341#Conessine, a steroidal alkaloid from Holarrhena pubescens has antiviral, antiplasmodial, anti-inflammatory, and neuroprotective effects.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6496801Conessine is a histamine H3-antagonist
https://pubmed.ncbi.nlm.nih.gov/26924015/ -
Hormones activate one of the bitter Taste receptors.
". androsterone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate with 0.1 µM and adrenosterone as well as pregnenolone with 0.3 µM, respectively, showed threshold concentrations in the submicromolar range."
https://pmc.ncbi.nlm.nih.gov/articles/PMC12915477/#nyas70172-sec-0080
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio they taste awful unless dissolved in tocopherol lol
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That is interesting about Chia seeds. Especially from a Peat perspective. (Or maybe I should say from my novice understanding of Peat.) Anything with seeds I've avoided since learning of Peat.
Could the powder of a Chia seed even be different from simply grinding the seeds?
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@Mossy Peat even said he can't see any value whatsoever in chia seeds, which is weird because they contain a lot of polyphenols, fiber and minerals, so there is at least some nutritional value there.
And he said if someone feels better from them it's probably the laxative effect, which is more or less ruled out in the above study.
So I still dont understand how it has these effects.
And it doesnt seem to be just the grounded seeds. There's another study I posted which used chia seed extract, which was very beneficial as well.
And IIRC another one used whole chia seeds.I think the powder and grounded seeds should be very similar. Unless the powder is somehow defattened. But suppose they would state that.
There was a thread on here recently that Omega 3s are essential and you need them for certain things. Ive only skimmed it, but maybe it has something to do with that.
So following the true method of knowledge I will order some grounded chia seeds and see for myself.
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@Mauritio Appreciate your thoroughness. It will be interesting to see what effect they have on you. I don't like the taste and feel of chia seeds, but maybe they could be used as a food supplement, like I do with liver.
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@Mauritio 5ht1a 1b both downreg sero produc
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Mauritio said:
A casual 7x increase in testosterone while it decimates prolactin. Not bad.
In the testosterone study they used 0.025g/L of chia powder in drinking water, which is an extremely low dose. This should approximately correspond to an HED of ~70mg.
Wild that even had an effect at all at that dosage.
There's another study using the same dosing protocol also in rabbits. So HED ~ 70mg.
And it shows strongly lowered cortisol, insulin, leptin and triglycerides. With a small increase in TSH.
It also drastically lowered one protein which is part of the HSP70 family. Peat used to write about the dangers of heat shock proteins, so lowering should be a good sign.
https://www.nature.com/articles/s41598-024-82175-3#Tab5
Many studies with Chia seeds use HEDs of 5/10/or even 50g. Often showing that the 10g or higher dose is most effective. While the lower dosage is relatively ineffective.
The above studies show that (at least in rabbits) a microdose might be all you need.
70mg/ day increased testosterone and lowered cortisol strongly.
If you want to replicate the study, measure 70mg with a mg scale and put in a big bottle of water and sip throughout the day. That is the closest thing to what they did in the studies.
So that way, you could get the benefits without overloading on PUFAs. -
@Mauritio I await a report of your experience
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