Pro Metabolic Substances Tier List
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@ethan 100mcg of T4, the liver produces 80% of T3 though
@lettheredeemed thats what T4 does lol. It’s like a drip of T3, and actually allows you to receive it every second in sub nano gram amounts. That’s what my passive aggressive comment to @lobotomize me was for lol -
@alfredoolivas is that enough t4 for your height and weight? is your TSH suppressed from this amount of t4? endogenously there is always some t3 being produced from the gland, so low dose probably isnt that harmful/catabolic
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@alfredoolivas lol yup. I do think I encountered more problems than I helped when I got on NDT a few years ago. after ketocarnivore (and a whole childhood of malnutrition and sugar avoidance), I think my liver was just shot and I needed direct t3. It’s just a super case by case basis, but I believe the avg person probably does fine on primarily t4 at lunch and dinner.
The one I’m really sour about is how they extracted calcitonin from NDT meds because they can prescribe that for it’s own cool properties. Long term when I’m rich I just want to take a high quality bovine blend NDT. Found a cool one for like 60+ bucks.
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@LetTheRedeemed lgs has a not-standardized one
I started my dog on it because she was on the low end of the t4 range and within 2 weeks she grew a mohawk of more fur from her head to her tail. or maybe it was the same fur but it just stood up nowhaven't measured her thyroid since tho so idk if its from that but it probably is I dont think I changed much else other than add low dose dhea
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Putting both Alcohol and Semaglutide in your S Tier is insane, especially when one of your own qualifications for that tier is "no drawbacks."
Both already have major established drawbacks, both from acute and chronic use. In addition to the potential problems that have already been established with Semaglutide, the drug hasn't even been on the market 10 years yet, meaning there could be other major issues that haven't even been discovered yet.
Beyond those issues, Alcohol isn't "pro metabolic." In itself, it is a toxin, and it produces an even more toxic substance (Acetaldehyde) when it is being processed to Acetyl CoA. It's highly reductive, helping to build up NADH. This directly opposes the actions of some of the other substances on your list, like Methylene Blue.
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@ZackVegas low doses of alcohol increases ATP production. There were zero drawbacks in MY Experience.
If this list was written on pure theory, then the whole list would be upside down.
But a few drinks and semaglutide I had no detrimental effects on me. So they are S tier. At least they were in March 2025
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@alfredoolivas Dinkov talked about how a few alcoholic drinks a day with food match optimal ethanol production by the body, and ethanol is one of the 2 or 3 substances that removes lipofuscin. Yes, all things with consideration and exception, use accordingly.
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@alfredoolivas what's a low dose
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@ZackVegas is methylene blue a perfect addition to an alcoholic mixed drink>?
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