Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use
-
@cs3000 have you ever gotten around to trying blue lotus (or whatever alternative you came up with)?
I was intrigued by this post on another thread.
And it's relatively cheap, so I'll give it a shot.I'll probably try one of those two:
https://www.magic-mushrooms-shop.com/de/blue-lotus-extract-tincture.html
https://www.magic-mushrooms-shop.com/de/blue-lotus-nymphaea-caerulea.html#customer-reviews
-
This post is deleted! -
@NoeticJuice thanks for the reply.
If their flowers are the "real" one, their extract should be as well, right?
Maybe I'll get that, but 19$ shipping to Germany is pricey.I hear you, but I'm mainly interested in the anti-serotonin, pro-dopamine effect @Mulloch94 describes in the post I linked above. So whatever he had , I want. Unfortunately the company he linked doesn't ship to Germany.
-
This post is deleted! -
This post is deleted! -
@NoeticJuice said in Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use:
I feel like these two threads should be connected
"The dopamine system of healthy, highly creative people is similar to that found in people with schizophrenia"Well, hypomania is what we want , I guess .
-
@NoeticJuice said in Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use:
The mechanisms Mulloch94 wrote about are those of nuciferine and apomorphine, not necessarily those of the plant extract. But if you just want the same/similar subjective effects, then the product(s) you were thinking to buy could be fine.
But he did get those effects (anti-serotonin and pro-dopamine) from the plant extract, so there should be some nuciferine and apomorphine in there. Or at least something that works along similar lines.
-
@cs3000 ketanserin
-
@NoeticJuice said in Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use:
Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
From what I understand from this thread, along with the ones NoeticJuice mentioned, we should favor keeping 5ht2a relatively higher (compared to other 5ht receptors), since it antagonizes other 5 ht receptors and also decreases agonist effects on the D2 receptor
-
This post is deleted! -
This post is deleted! -
@NoeticJuice said in Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use:
A basic theory of psychosis and related phenomena:
- The left hemisphere is extremely perceptually dominant.
- The left hemisphere distorts what is given to it by the right hemisphere, leading to hallucinations, delusions and a breakdown of reality.
- In a system that is dysfunctional in this way, reducing signal filtering at the thalamus acts as increasing fuel for the delusions etc., while in a person whose hemispheres are better balanced, it would instead fuel creativity.
Even if this theory is true, it would still only be a general, bigger-picture view. There are probably refinements and a lot more detail that could be added. For example, the information in the OP of this thread could be integrated, and more about specific brain regions could be added.
Some additional notes:
- In schizophrenia, it might not just be about left-hemisphere dominance but also right-hemisphere damage/deficit.
- IIRC, schizophrenics generally have reduced myelination in the brain. If their right hemispheres have less white matter than normal, then their right hemispheres, in a way, might be less right-brained than the average right hemisphere. Increasing myelination might be something worth looking into.
Little or no salt and meat, plus more plants, fruits, and dairy products can contribute to a person being more prone to visions ,“hallucinations”, dreams,Sunlight and EMFs can also contribute. In my experience, visions, hallucinations, and dreams are either manifestations of the body's internal agency/agency attempt, which may include stored engrams/memories from the person's past experiences, engrams/memories from other living beings/sources, that have entered the person's body in the past and have been stored, or direct receptions of information/energy from external sources, whether foods, drugs, emf, the sun, the moon, other living beings, or supernatural beings, which can include past, present, and future informations. It is not necessarily optimal in the long term to be prone to these things, as it can be associated with reduced physical/mental resilience or even damage.
Yet , once a person is in that state, visions/hallucinations/dreams can have a positive effect and lead the person towards a better internal agency and a better energetic state. Visions/hallucinations/dreams can contain elements that indicate to the person what they need to return to an optimal energetic state
-
This post is deleted! -
@NoeticJuice i include schizophrenia or drug-induced psychosis in my comment above
-
While looking into studies on blue lotus (Nymphaea caerulea), I found a very interesting study on a plant from the same genus called N. lotus.
It was on mice with hyperprolactemia that received different dosages of N. Lotus, while bromocriptine served as the positive control group.
Not only was it able to lower prolactin, but at the highest dose, it lowered prolactin more than bromocriptine.At that dose it even lowered prolactin below the control groups value, which didn't receive prolactinergic medication .
They gave rats an HED of 30mg of Bromo, which is a hefty dose.
On top of that it also drastically increased mices progesterone. Again, outperforming bromocriptine and even the control group.
It also lowered estradiol.
I haven't done enough research yet, but that study alone makes me really want to try N. lotus.
https://scialert.net/fulltext/?doi=ajb.2017.91.98 -
Here's another study in male animals where it had a positive impact on male reproductive health. They didn't test hormones, but numbers of offspring drastically increased in the N. Lotus group and sperm health did as well.
https://ppj.phypha.ir/browse.php?a_code=A-10-935-1&slc_lang=fa&sid=1
-
@NoeticJuice said in Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use:
@user2 I was thinking more in the context of things like schizophrenia or drug-induced psychosis.
I think visions are facilitated by the right hemisphere. In the case of visions without psychosis, while the person still remains sane, there's less distortion, so they can be better used for one's own benefit. I think it's similar for dreams.
Whatever people see from taking drugs is almost certainly distorted to a greater or lesser degree.
If someone feel what he is seeing on drugs is real, it is real, real/reality is a feeling. If by distortion you mean not as real, not as true, illusory, it aint necessary any of these, potentially either the drug change the state/structure of the person temporary therefore the person perceive a different reality during this time, or what the person is seeing on drugs is the body inner agency/attempt to inner agency, and the differents drugs elements do manifest/are perceive as differents visual phenomenons, and it is all real
-
This post is deleted!
