Terrible Progest-E reaction. NEED to sort it out.
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What @zorba990 wrote.
Possibly hand that panethine also to your relative perhaps you share common SMVT phenotypes.
@thelion said in Terrible Progest-E reaction. NEED to sort it out.:
NAFLD, and celiac disease, including a maternal relative with an intolerance to aspirin due to it causing constipation.
@zorba990 How do you feel excess acetylcholine? Swelling of mucosa and a runny nose with overall increased peripheral circulation and warmth and feeling whiny? Calcium-pantothenate dissolves really quickly btw so you could use the contents of capsules instead of solid tablets.
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I am not scientifically savvy enough to provide any other description than that I get constipation-like symptoms as well from progesterone, and the mucosa issues, but manifested in dryness of the nasal passages, not runny nose. Maybe it is intermittent — runny, then dry; but I forget exactly. It's been years since I've taken progesterone. All in all, I get what has chronically been an issue in my life — what I'd call dryness related symptoms.
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At which doses does The lion experience this? Even small doses topically? Has The lion tried any methods of inducing a bowel movement (like high dose magnesium or carrot salad) when these symptoms happen and even that doesn't work?
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@thelion Word.
Have you tried other formulations of progesterone, like Idealabs progestene or whatever it's called?
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@Mossy
In the mentioned context of Acetylcholine that overall dryness of yours could be a sign of generally low ACh levels.
If you're up for an adventure you could hypothetically seek an anesthesiologist to i.v. inject you with ACh in order to feel and observe your bodily reactions to elevated levels of it. As such a vague diagnostic approach publically doesn't really count as a valid reason I doubt anyone's up to do that "just for fun", though. -
The lion says rawr
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Nothing to add here that is earth shattering:
But
Think of progesterone as pro-gestation
With that
Constipation is very common- a big issue during pregnancy for many womenSimply lay off
You could try upping your carbs or even kcal to see if you tolerate it better
But that takes intentionality and time -
It might have to with bile acids and the gallbladder.
There is a progesterone metabolite that modulates the bile metabolism in such a way that it can cause cholestasis symptoms, constipation is one of them.
IIRC it had to with the bile acid receptor FXR.You could try increasing your fiber intake via carrots, bamboo shoots or oat bran.
You could also try adding a bit of olive oil to your diet since the fatty acids in it have a tendency to cause a stronger bile release than coconut oil.
Another option would be trying FXR agonists like bile acids, androsterone, cafestol, ... -
@CrumblingCookie
Thank you for the information. It was interesting to read of ACh being a possible factor. My first thought was to attempt to get this with food; or as @zorba990 mentions, pantothenic acid or pantethine forms of vitamin B5. But, the last 15 years has all but put me off of all supplements. I simply can't take them without adverse effects. So, for now, this ACh experiment will have to wait. Though I will make note of it.
