Aspirin dangerous for kidneys?
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Is it true that cyclooxygenase enzyme blockers (like aspirin) harm kidneys through reducing blood flow to the kidneys by their reduction of prostaglandins?
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Aspirin and kidneys
While generally considered safe at low doses for heart health (81-100mg), higher doses or prolonged use can negatively impact kidney function and, in rare cases, lead to liver issues.
However, retention of uric acid and creatinine caused by aspirin in doses of 75 to 325 mg/d has been seen by elderly people (aged 56 to 98 years) in a study for 2 weeks. (1)
Kidney function is often slower by old people (excretion flow).- DOI: 10.1016/S0002-9343(03)00436-4 (Science Direct, 2003).
Early and late effects of low-dose aspirin on renal function in elderly patients
Aspirin is a blood thinner since it has an impact on platelet aggregation (coagulation). It reduces blood flow.
It has an impact too on the detox pathway Cyp450: It means that toxins take more time to get out through the kidneys. Like with curcumin and naringenin from grapefruit. And a lot of more molecules. Mind if you combine several medicines...Thus, aspirin could complicate kidney function, particularly in individuals with pre-existing kidney issues or when taken in high doses, on a regular base.
Once a week I take a mix K1 and K2 when I take white willow bark extract (salicyline).
K2 MK4 every two days 1 mg ( 1 000 mcg).Aspirin and kidney function and prostaglandins (Google IA)
Aspirin, like other nonsteroidal anti-inflammatory drugs (NSAIDs), can affect kidney function by inhibiting prostaglandin synthesis (cox-1 & 2). Prostaglandins are important mediators of various physiological processes, including those in the kidney. Aspirin's inhibition of prostaglandin production, specifically COX enzymes, can lead to reduced renal blood flow and glomerular filtration rate, potentially impacting kidney function.
Prostaglandins play a crucial role in maintaining normal kidney function. They help regulate blood flow to the kidneys, control sodium and water excretion, and influence the release of hormones like renin.Impact on Renal Blood Flow
Prostaglandins help dilate blood vessels in the kidneys, ensuring adequate blood flow. When aspirin inhibits prostaglandin synthesis, it can lead to vasoconstriction (narrowing of blood vessels), reducing blood flow to the kidneys. Reduced renal blood flow due to aspirin's action can decrease glomerular filtration in the kidneys.Comment (LucH): Said in another way, toxins take more time to be filtrated. Accumulation is then possible. The effects of aspirin on kidney function are generally reversible upon discontinuation of the drug, 2 weeks after the stop.
- DOI: 10.1016/S0002-9343(03)00436-4 (Science Direct, 2003).
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@Adsquest yes. I quit taking over 600mg and try to stay here or less when needed. I was looking up this exact question. I was having some bladder/kidney pain. Not sure if k2 will prevent this.
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@Corngold said in Aspirin dangerous for kidneys?:
I was having some bladder/kidney pain
Were you taking HD vitamin D3 or eating veggies high in oxalate? This could explain the difficulty in managing "lithiasis problems".
Useful info
Vitamin K and Lithiasis (e.g. calcium stones)
While there's no direct link between vitamin K and lithiasis (stone formation), some research suggests that vitamin K2 may play a role in preventing calcification in some tissues, especially when taking HD vitamin D3. This could be relevant in the context of certain types of lithiasis, like kidney stones, where calcium deposits are involved.
doi: 10.3390/nu13020691 2021 NIH – The Medical Benefits of Vitamin K2 on Calcium-Related Disorders.Aspirin and Sodium
Aspirin's impact on sodium balance is complex and influenced by its effects on prostaglandin synthesis.
Prostaglandins, particularly PGE1 and PGE2, play a role in regulating sodium and water excretion in the kidneys. We’ve seen aspirin has an impact on Cox-1 & 2, through PGE1 pathway.
Studies suggest that PGE1 can inhibit sodium transport in the kidneys, potentially leading to increased sodium excretion. Possibility. Aspirin's inhibition of prostaglandin synthesis can, therefore, indirectly affect sodium balance, although the exact mechanisms and extent of this effect are still being investigated.
Some studies suggest that aspirin can reduce sodium reabsorption in the kidneys, while others show no significant effect. Renal sodium excretion could be impaired by weak mechanism of sodium management, with an additional effect from blockade of prostaglandin.
DOI: 10.1016/0090-6980(75)90011-8 1975 NIH – Effects of aspirin on renal sodium excretion, blood pressure, and plasma and extracellular fluid volume in salt-loaded rats. -
@LucH no, and also wasn't going heavy on milk which has d3. I think it's mostly from taking 600mg or more daily for about 2 - 3 weeks. I've also noticed occasionally easy bruising on legs or arm when taking aspirin.
