Is Low Dose DHT Suppressive?

Nomanarch

I keep seeing anecdotal claims that physiological (non-replacement) DHT doses aren't suppressive and in fact permanently upregulates 5-AR. However I haven't found any studies supporting either claim (it could be a skill issue on my end, but I am critical of advocacy for exogenous hormone use that suppresses HPTA). So, is low dose DHT suppressive, and if not, is there any evidence for that claim? Does exogenous DHT supplementation permanently upregulate 5-AR (and might that make suppression worth it)?

CrumblingCookie

Here you are:

On the Role of Dihydrotestosterone in Regulating Luteinizing Hormone Secretion in Man

Impact level of dihydrotestosterone on the hypothalamic-pituitary-leydig cell axis in men

and as a bonus (+ Mauritio's linked studies about estrogen/aromatization but not DHT being the actually catabolic effector of high testosteron):
Prolactin secretion in the human male is increased by endogenous oestrogens and decreased by exogenous/endogenous androgens

Wrt ARs: Estrogens actually severely downregulate them. DHT both inhibits aromatization, seems to have some antagonizing effect on ERs IIRC, and it speeds up estrogen breakdown by EST estrogen sulfotransferase.
And as you will read in the links above, DHT (in stark contrast to synthetic AIs) penetrates across the blood--testis barrier to exert the aforementioned effects also there.

sunsunsun

@Nomanarch how could it be permanent up regulation lol

jamezb46

@CrumblingCookie

Pretty sure the aromatase inhibitor ATD (Androstatriendione) both inhibits aromatase and increases DHT by slowing the metabolic deactivation of DHT into the -diol metabolites

So, theoretically ATD + something like Proviron would be anabolic

https://en.wikipedia.org/wiki/1,4,6-Androstatriene-3,17-dione

https://pubmed.ncbi.nlm.nih.gov/3773531/

CrumblingCookie

@jamezb46 Does the inhibition of the -diol conversion make ATD notably better than ordinary exe?

I've yet tried neither proviron nor DHT. But I'd like to use the latter first, as a benchmark, and not so much for a heavily criticized lack of anabolism of DHT but for its anticipated restorative effects, at some time when there's less essential conditions on my plate. Along with ARA-290 and other stuff then.