Separation in Pansterone bottle
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I have a new bottle of Pansterone that must have gotten cold during shipment because I can see some kind of precipitate if I put a flashlight up to the bottom of the bottle. It looks like some kind of crystals, not very big and not very many, but they are there.
On RPF @haidut suggested a few seconds in the microwave and then some vigorous shaking. Well, I tried that, and there are still crystals. Is there anything else I can do or this bottle doomed or did it just get a little too much DHEA/preg added, in which case, there isn't actually a problem?
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@engineer for me; 10 secs in microwave is needed.
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@alfredoolivas what microwave power? Mine is "1000W" but it is definitely more than that and 10 seconds might be a little too long
Update: I tried it on 6 seconds (I first did 4 seconds) and this appears to have gotten rid of most of the crystals. However, there are still a few left.
Update 2: It appears as though shaking might not be the best way to distribute the crystals because they don't flow through the solvent very well. I'm trying to lay the bottle on its side and periodically rotate it in order to maximize crystal distribution within the liquid.
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@engineer Mine is 1000W too I think
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Ok, looks like most of the DHEA/preg crystals are gone with the bottle flip trick...but looking at my 6 keto p4 bottle, it appears to have the same exact problem but microwaving it did NOT fix it this time. I just so happened to have received the tocopherol/MCT version earlier, and like expected, it precipitated. But a simple shake seems to have fixed that one.
Seems like the ethanol/SFA version of 6 keto p4 is a pretty terrible product!
Thinking of just megadosing whatever is left until it runs out, then filling it with MCT oil, any thoughts chat? Maybe I should get a milligram scale to quantify how much was actually lost
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@engineer It doesn't dissolve in MCT alone. You need pure tocopherol
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fwiw and maybe this will help you, but I can tell you that micronized DHEA dissolves just fine and stays in solution in straight EVOO at 5mg/ml. micronized progesterone ive dissolved at 30mg/ml in a mix of tocopherols and EVOO. The tocopherols and EVOO is a NOW product
(specifically that one, NOW has various sizes and mixes in different or similar bottle sizes that are all different so you have to carefully read the labels to see what you're getting). For the progesterone, 50mg/ml in the above actually precipitated out even at room temp.I haven't tried pregnenolone but chatgpt says 15-30mg/ml in straight olive oil so I would just do 10mg/ml.
And lastly, I am not a solution mixing expert, but apparently dissolving multiple substances in the same solvent can actually get more in there without a linear effect on max solubility. So i.e. a 5mg/ml DHEA in olive oil solution can still take some progesterone without reaching max solubility capacity for either. l
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@sunsunsun said in Separation in Pansterone bottle:
fwiw and maybe this will help you, but I can tell you that micronized DHEA dissolves just fine and stays in solution in straight EVOO at 5mg/ml. micronized progesterone ive dissolved at 30mg/ml in a mix of tocopherols and EVOO. The tocopherols and EVOO is a NOW product
(specifically that one, NOW has various sizes and mixes in different or similar bottle sizes that are all different so you have to carefully read the labels to see what you're getting). For the progesterone, 50mg/ml in the above actually precipitated out even at room temp.I haven't tried pregnenolone but chatgpt says 15-30mg/ml in straight olive oil so I would just do 10mg/ml.
And lastly, I am not a solution mixing expert, but apparently dissolving multiple substances in the same solvent can actually get more in there without a linear effect on max solubility. So i.e. a 5mg/ml DHEA in olive oil solution can still take some progesterone without reaching max solubility capacity for either. l
I will try this, but also of note is how my new 6 keto p4 MCT/tocopherol bottles are also filled with crystals. 10s in the microwave and lots of shaking later and they are still not dissolved. Is it possible that there are just always crystals because this is seriously annoying. If even MCT/tocopherol can't do it, maybe EVOO/tocopherol can't either.
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@engineer apparently 6 keto p4 is quite oil soluble and the range to try is 20-35mg/ml, so I would just do 15mg/ml. if you get a magnetic stirrer and a beaker just dump your idelabs bottle in there, and then dilute it with however much olive oil, and drop in the stirring capsule and set it on low and keep it away from too much natural light and let it run for a few hours. a little heat can speed it up a lot but it isn't really necessary.
apparently keeping dust out of it is important to prevent the solution crashing out into crystals like you're describing, so put a piece of paper on top of the open beaker as it runs and then store with a lid in whatever bottle you use.
if you buy a magnetic stirrer with a heat function be aware that the Chinese one I got has an insane heating function where even the lowest of the low setting is burning hot so maybe look for one with better temp controls. i can't imagine how hot mine would get if I put it on maximum heat.
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@sunsunsun said in Separation in Pansterone bottle:
Accurate concentrations -
Is the reason why the Idealabs version isn't dissolving because the concentration is too high? The Pansterone is now fully crystal free and that's 2mg/drop so something is clearly different with 6 keto
