DNP - Soon to get Approved for Fat Loss in a Country Near You
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Most of us are aware of the recent push to develop "weight-loss" drugs that will help thin out the obese western population. The ones that are currently being used, the GLP-1's, do so through less than perfect means.
Many are aware of the recently discovered BAM-15, which has been studied in rodents as being protective against various metabolic conditions and stressors.
There is, however, to my knowledge, not a single human study using BAM-15, even though it is available on the black market.
What will be of interest to the members of this forum, however, is that Rivus Pharmaceuticals has developed an orally available prodrug to DNP they call HU6 (that's right - it converts to DNP). It has been studied in humans to significantly reduce liver fat associated with obesity and metabolic syndrome.
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00198-X/abstract
In fact, a Phase II trial has already been completed in which various doses were administered that closely mirror the underground doses of DNP to achieve weight loss. Liver fat reductions were significant and there were no deaths or serious adverse events.
Only a matter of time before Big Pharma slaps a new label on good old DNP, which since the '20's was used to lean out the fatties.
DNP
HU6
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@jamezb46 Seems to have alot of side effects, including cardiac ones.
"In those treated with HU6, flushing (19 [32%] participants), diarrhoea (15 [25%] participants), and palpitations (seven [12%] participants) were the most frequently reported TEAEs "
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True, I wouldn't use it myself. It should have similar safety profile to DNP itself. The innovation is that the conversion to DNP is slow which means there is more of a "controlled burn" than with DNP itself
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@jamezb46 Surely, given the 72 hour half life (iirc), the steady state concentration would be the same eventually?
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Do you have a reference for the human half life of 72 hours for oral administration?
According to the below report by the CDC, DNP given orally to dogs does not accumulate.
"The time course of plasma concentrations of 2,4-DNP following oral administration to dogs (one per
dose) at 5, 12.5, or 25 mg/kg gave no evidence of a trend towards higher plasma levels with continued
daily dosing (Kaiser 1964). Hence, 2,4-DNP did not appear to accumulate."https://www.atsdr.cdc.gov/toxprofiles/tp64-c3.pdf
Likewise,
"The half-time for
absorption of 2,4-DNP following gavage administration of a single 22.5 mg/kg dose to mice was
0.5 hours based on serum concentrations of 2,4-DNP measured 1, 3, 6, 12, and 24 hours after dosing
(Robert and Hagardom 1983). Similarly, peak plasma concentrations occurred within the first 0.5–
2 hours of gavage doses up to 22.5 mg/kg in mice (Robert and Hagardom 1985) or 25 mg/kg/day in rats
(Perry et al. 2015a,b), and within the first 0.5–4 hours of oral doses up to 125 mg/kg in dogs (Kaiser
1964) "So, oral DNP does indeed seem to be rapidly absorbed.
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@jamezb46 Not 72 hours, that was off the top of my head. But there seems to be so much variance of reportedhalve lives
https://pmc.ncbi.nlm.nih.gov/articles/PMC4534549/#sec9
"The elimination half-life (t 1/2) of 2,4-DNP was (88.78±14.66) h in the routine HP group, while the t 1/2 was only (54.58±12.92) h in the intensive HP group. The t 1/2 of 2,4-DNP in the intensive HP group was apparently shorter than that in the routine HP group, with statistical significance (t=4.535, P=0.001)."
But the FDA says: "The elimination half-lives for the terminal phase were estimated at 10.3 hours for 2,4-DNP, 46.2 hours for 2-amino-4-nitrophenol, and 25.7 hours for 4-amino-2-nitrophenol."
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It definetley does accumalate though, which is why deaths are never instant - at least to my knowledge - so it must have quite a long half life.
