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    Fenclonine

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    • alfredoolivasA Away
      alfredoolivas @engineer
      last edited by

      @engineer I’m sure the taladafil came in handy

      engineerE 1 Reply Last reply Reply Quote 0
      • engineerE Offline
        engineer @alfredoolivas
        last edited by

        @alfredoolivas it hasn't quite happened yet but could soon.

        alfredoolivasA 1 Reply Last reply Reply Quote 1
        • hwisdomH Offline
          hwisdom @hwisdom
          last edited by

          selegiline is btw rlly goated it does live to the hype, better than bromantane imo

          MILF
          man I love fasting

          1 Reply Last reply Reply Quote 1
          • alfredoolivasA Away
            alfredoolivas @engineer
            last edited by

            @engineer inshallah

            engineerE 1 Reply Last reply Reply Quote 0
            • engineerE Offline
              engineer
              last edited by

              If pramipexole doesn't work out, it looks like you can also increase dopamine and (hopefully) lower serotonin through MCR agonism. That would mean a peptide like melanotan 2 or PT-141. I already have some melanotan 2 but the jury is still out on melanoma risk so that means PT-141.

              hwisdomH jamezb46J 2 Replies Last reply Reply Quote 0
              • engineerE Offline
                engineer
                last edited by

                Looks lik maybe MCR agonism is akin to a stress response?

                Appears as though metergoline is the way to go even though it mostly works on serotonin

                Now the challenge is finding bulk metergoline

                hwisdomH 1 Reply Last reply Reply Quote 0
                • hwisdomH Offline
                  hwisdom @engineer
                  last edited by

                  @engineer melanotan makes you black through NO stimulation btw, this is why it also gives u massive boners, prolactinogenic, not peaty, fuck melanotan all these mechanisms abt it are just speculations because "erm akshually melanin good!", didnt peter thiel like fund these popular peptides or smth idfk

                  MILF
                  man I love fasting

                  engineerE 1 Reply Last reply Reply Quote 0
                  • hwisdomH Offline
                    hwisdom @engineer
                    last edited by

                    @engineer metergoline is goated, any chinese nigga on echemi would sell it to you for around like 400$ a gram, 4mg a day for me gave me all the famous benefits of blocking serotonin at a significant rate, but if you can try getting ur hands on the brand name Liserdol product, its gonna be much easier

                    MILF
                    man I love fasting

                    1 Reply Last reply Reply Quote 0
                    • engineerE Offline
                      engineer @hwisdom
                      last edited by engineer

                      @hwisdom it doesnt specifically touch NO, it just stimulates melanocytes through mc1r which is normally agonized by alpha msh, and NO increases mc1r expression like you would expect in a stress state

                      https://grok.com/share/c2hhcmQtMw_7fd6d676-eb61-41b6-8bff-c75dc29acb22

                      remember, iNOS is bad and eNOS is fine

                      1 Reply Last reply Reply Quote 0
                      • engineerE Offline
                        engineer @alfredoolivas
                        last edited by engineer

                        @alfredoolivas said in Fenclonine:

                        @engineer inshallah

                        I just gave mami a Ray Peat starter kit

                        20260424_145843.webp

                        alfredoolivasA hwisdomH 2 Replies Last reply Reply Quote 1
                        • alfredoolivasA Away
                          alfredoolivas @engineer
                          last edited by

                          @engineer you don’t cheap out, I like it

                          1 Reply Last reply Reply Quote 0
                          • hwisdomH Offline
                            hwisdom @engineer
                            last edited by

                            @engineer I eat out my dogs asshole

                            MILF
                            man I love fasting

                            1 Reply Last reply Reply Quote 0
                            • jamezb46J Offline
                              jamezb46 @engineer
                              last edited by

                              @engineer Maybe you would like Bupropion for this purpose. It's easily available.

                              In time there is life but no knowledge; outside time there is knowledge but no life

                              hwisdomH 1 Reply Last reply Reply Quote 0
                              • hwisdomH Offline
                                hwisdom @jamezb46
                                last edited by

                                @jamezb46 it blocks serotonin like that???

                                MILF
                                man I love fasting

                                jamezb46J 1 Reply Last reply Reply Quote 0
                                • jamezb46J Offline
                                  jamezb46 @hwisdom
                                  last edited by

                                  @hwisdom It doesn't block serotonin but it increases dopamine and as Georgi has written many times whenever dopamine increases serotonin tends to decrease because of enzyme competition. There are exceptions but in general the above is true as a rule.

                                  In time there is life but no knowledge; outside time there is knowledge but no life

                                  alfredoolivasA 1 Reply Last reply Reply Quote 0
                                  • alfredoolivasA Away
                                    alfredoolivas @jamezb46
                                    last edited by

                                    @jamezb46 it blocks serotonin too, and it is a dopamine agonist. If anything it reduces dopamine

                                    1 Reply Last reply Reply Quote 0
                                    • W Offline
                                      wester130 @engineer
                                      last edited by

                                      @engineer extremely difficult to buy from those websites

                                      engineerE 1 Reply Last reply Reply Quote 0
                                      • engineerE Offline
                                        engineer @wester130
                                        last edited by engineer

                                        @wester130 what exactly is extremely difficult to buy?

                                        1 Reply Last reply Reply Quote 0
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