Idealabs Supplements Review
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I have been using a whole bunch of the Idealabs supplements for about a month and a half now, so here's my review of the following (ranked from best to "worst"):
- Pyrucet
- Lisuride
- 6-keto-p4
- Androsterone
- 11-keto-DHT
- Gonadin
- Kuinone
- Pansterone
Pyrucet
This is my favorite one by far. Whenever I take it with a cold glass of OJ I can feel myself burning the sugar much faster thanks to the increased PDH than when I don't take it. As a consequence, though, it means I can get extremely tired and hypoglycemic if I'm not on top of consuming carbs. I also seem to be getting more used to lower FFAs as I'm feeling the carb burning effect less than when I started. If you try one thing from Idealabs this should be on your shortlist because you can feel the effects right away and I predict it'll make the biggest difference for many.Lisuride
It's literally happiness in a bottle. No, it's not magic, but it does sort of lift you up if you're lethargic or not in the greatest mood. As a consequence of being a dopamine agnoist it smashes prolactin levels, and I could intimately feel the effects of that, if you know what I mean. The prolactin effect also persists longer than the 2 hour half life due to currently underesearched mechanisms. This is second only to pyrucet in terms of the effects you can feel.6-keto-p4
I have always had a chronic stress issue and this has resulted in chronically skyrocketed cortisol levels. In old photos I can tell this from how I looked. So, upon learning about this mystical progesterone derivative I just had to try it. I started with 15mg and could soon feel the cortisol getting blocked. Things that previously stressed me out now just feel meh. Also, as cortisol is what largely triggers fat breakdown into sugar, along with preventing muscle breakdown, it makes the hypoglycemia issue with pyrucet slightly worse. The fix is just to consume carbs constantly. I'm now taking 25mg a day and it may have helped me accidentally become a bodybuilder, but I'm not sure. 6-keto-p4 would be my favorite product here if not for how long you need to take it to notice effects and the sheer expense of taking 25mg+ a day. I'm thinking of bumping it up to 30mg.Androsterone
I originally got this for a pheromone effects. Well, I can't easily tell if it works as one or not, but whenever I used it on my arms (10-15mg) I could feel the GABAergic effects as well as plummeted estrogen levels. It really works!11-keto-DHT
I don't know how effective this one is. 11-keto is interesting in that it has a much longer half life than plain old DHT and is readily available. However, it's by far the most expensive thing here (as expensive as lisuride), so I've limited myself to 10mg a day. It may have made my facial or head hair grow faster but it's hard to tell for sure because androsterone did so as well. Let me know if I'm not just using enough.Gonadin
Similar story with Gonadin. I took it for about two weeks on its own and didn't notice much of change, although I don't have the bloodwork to say for sure. However, it may have been similar to when I took Tongkat Ali years ago where it took time to make a difference. Theoretically from the studies provided, it should make a difference, so that's why I'm still taking it with everything else.Kuinone and Pansterone
I can't assess these on their own because I use them together along with androsterone as in Haidut's Magic Androgen Trick. I believe that protocol has made a difference, but like with gonadin, I don't have the bloodwork to back it up. I normally use 6 drops of pansterone and 2 drops of kuinone per day but recently tried 9/3 drops.What I want to try next
I want to try Progestene, Metergoline, and Lapodin because progesterone appears to be a strong GR antagonist, metergoline might combine well with lisuride or be as good on its own, and emodin appears to be a cortisol production blocker. -
@engineer progesterone is a GR AGONIST
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@alfredoolivas really, so why does Haidut say progesterone is anabolic
Edit: iirc it's an stronger antagonist than even testosterone
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@alfredoolivas wut…
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i value kuinone way higher as its a reasonably priced way of getting what i think is legit k2 mk4 premixed . ive taken big doses and felt what i think are too much estrogen suppression , as well as liver detox effects
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@alfredoolivas yeah, well, Wikipedia might be fake news here
https://lowtoxinforum.com/threads/the-anti-cortisol-mechanism-of-progesterone.14590/
"...Cortisol binds both the glucocorticoid receptor and the mineralo corticoid receptor; progesterone binds both the progesterone receptor and the glucocorticoid receptor, for which it is an antagonist."
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@engineer If it were anti cortisol, we would see reductions in amino transferases such as ALT, AALP and GGT. They don't and may even increase it.
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@alfredoolivas so is Haidut's referenced study bogus?
another one:
https://www.lowtoxinforum.com/threads/the-anabolic-effects-of-progesterone.16381/
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@engineer It certainly isn't 85% as anabolic as methyltestosterone. Perhaps rodents convert progesterone into androgens via the backdoor pathway more than human
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@alfredoolivas does this have implications for 6-keto? If so, are there any other good GR antagonists comparable in safety to prog/6kprog?
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@engineer most steroids are really shitty at blocking the GR. Even trenbolone is a poor functional antagonist. Androgens exhibit their anti glucocorticoid effects by blocking the transport of the GR receptor to the nucleous.
Methyltrenbolone has the highest affinity iirc. It has such a long half life that it will constantly block it's receptor against the nanogram amounts of cortisol being produced every second.
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@alfredoolivas the big problem with all the trenbolone family members is the nasty secondary effects
https://lowtoxinforum.com/threads/trenbolone-experiences-log.37957
It sounds so good to have that much cortisol blocking but it otherwise isn't Peaty
Or is methyl tren different?
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@alfredoolivas hold on, since DHT is highly androgenic, doesnt that mean it would be anabolic as well? 11-keto is more resistant to metabolism so maybe it has a significant effect here? It appears as though 12 drops per day of 11-keto-DHT would cost the same as 25 drops of 6-keto-p4.
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Meldonium is wayyyyy better than pyrucet
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@heyman said in Idealabs Supplements Review:
Meldonium is wayyyyy better than pyrucet
what has Ray Peat said about it?
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@engineer It gets deactivated in muscle tissue. Even methylated DHT, mestanalone, which is resistant to metabolism, was classed as androgenic and not very anabolic
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@alfredoolivas now, even though it isn't directly anabolic, could it assist in achieving that goal by lowering cortisol and prolactin?
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@engineer I think prolactin is anabolic, if i remember correctly. It probably lowers cortisol via reduced AcTH
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@alfredoolivas cite some studies
I can't find anything saying prolactin is positive in anything but thymus regeneration and dopamine suppression/serotonin production
