moggy chicken log

alfredoolivas

alfredoolivas

week 14: 71.5kg down from 81.1kg, Salt and fluid restriction is definitely thermogenic. I can’t tell if appetite has changed.

Doing 12g of salt spread throughout the day. Weight jumped up to 72.2kg, mayhaps it’s coming down. I will keep on doing this. I scored high on Mensa denmark (121 IQ), so I think it’s a diet that supports cognition. That’s not even a flex btw, you read for my experiences, you get my experiences; the good and the bad

sunsunsun

wait, are you off GLP-1 ? if so why dont you use it?

secondly, nice work on the Mensa test

alfredoolivas

@sunsunsun I’ve been off for a year? That’s news? Not even trying to make a joke lol, I would have mentioned that I was taking them on this thread. My motility is too slow already, so I would be at greater risk of gastoparesis, I am not hyperphagic and there are anti dopamine side effects.

Thanks

LucH

@alfredoolivas said:

My motility is too slow already, so I would be at greater risk of gastoparesis

Resolor 0.5 mg one hour before bedtime to optimize a lazy MMC.
If dysbiosis:
Erythromycin and rifaximin both have potential roles in addressing a "lazy" gastrointestinal migrating motor complex (MMC), but they work through different mechanisms. Erythromycin, a prokinetic agent, directly stimulates the MMC and gastric emptying. Rifaximin, a poorly absorbed antibiotic, can improve symptoms associated with MMC dysfunction, particularly in cases of small intestinal bacterial overgrowth (SIBO) and related conditions like IBS-D, by reducing methane production and modulating the gut microbiota.

alfredoolivas

@LucH thanks boss. Resolor would work well, I take nicotine to have a bowel movement everyday and aparrently it works via serotonergic/ cholinergic mechanisms. does it stay local in the gut?

I did have 3 bowels movements on Monday. I was not taking aspirin and consumed pufa the day before. Do you think the lack of prostaglandins can cause constipation?

I don't think I have a gut overgrowth, my gut doesn't get bloated or I fart, it's just digestion is so slow sometimes...

LucH

@alfredoolivas said:

it's just digestion is so slow sometimes...

Yes, I understand: I see 2 possible problems:

lack of enzymes when overloaded. When my digestion is lazzy I take one caps (enzymedica lipogold). + one stimulation at the evening for bile. Only when required.
lazy MMC (interprandial digestion)
Targeting MMC dysfunction in lazy bowel syndrome
Resolor (prucalopride) is already a selective 5-HT₄ agonist — it is stimulating serotonin receptors, specifically the ones that drive propulsive motility and enhance MMC activity in the small bowel. So that box is already ticked, and ticked well.
Adding broader serotonergic stimulation won’t do the job.
Acetylcholine receptors
Well seen but not appropriate so. Why? Chasing acetylcholine receptors without fixing the MMC timing is like pressing the accelerator when the ignition isn't firing.
What actually targets the mechanism:

Motilin rhythm re-education— fasting windows timed to allow full MMC cycles (ideally 90–120 min of genuine inter-meal fasting, no snacking). Best 180-240 minutes.
• Ghrelin axis — ghrelin is a potent motilin-receptor agonist and MMC driver; avoiding late meal (after 8 PM) protects the biological rhythms.
• Prucalopride at the right time is already the most mechanistically precise pharmacological lever available. The best one. I've used it to re-inialize a lazy transit with dysbiosis (+ essential oils, with a protocol)

alfredoolivas

@LucH Gotcha thanks, please share the protocol if possible

LucH

@alfredoolivas said:

the protocol if possible

Yes, OK, but tomorrow.
Sth else: Adrenal stimulation
When I want to stimulate energy (within 2 hours after wake up), I massage the dorsal area where the adrenal glands are located with essential oil in a base (mainly black spruce essential oil, with Scots pine and andiroba) (épinette noire et pin sylvestre). Contraindication: hormone-like action (cancer).

LucH

@alfredoolivas said:

share the protocol if possible

For general purpose:
How to stimulate MMC (lazy interprandial movement)

Definition of MMC
When using a prokinetic as standalone solution or a combo with an antibiotic and which one (erythromycin or rifaximin).
How to use EO (dose and protocol)
*) The migrating motor complex (MMC)
MMC stands for migrating motor complex
MMC is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (= interprandial phase) (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic.
NB 1: I’ve used Resolor 0.5 mg, as prokinetic (1 tablet 1 mg cut into 2 pieces) which is classified as laxative but not used so).
NB2: When the gastro-intestinal problems last for more than 3 months, we have to suppose there is bacterial overgrowth or inappropriate colonic phyla in the second part of the colon. At his point, the need for antibiotic is required (medical assistance).
Rifaximin is the most commonly prescribed antibiotic for small intestinal bacterial overgrowth (SIBO) and is considered a good option for addressing lazy transit and bacterial overgrowth in the second part of the colon. Rifaximin is often the first-line treatment for SIBO, with studies showing eradication rates of up to 84% (with assistance of a healthcare professional).
NB: Erythromycin, as a prokinetic drug, accelerates gastric emptying in both healthy individuals with normal gastrointestinal function and in patients with critical gastroparesis

*) Which antibiotic
Erythromycin and rifaximin both have potential roles in addressing a "lazy" gastrointestinal migrating motor complex (MMC), but they work through different mechanisms. Erythromycin, a prokinetic agent, directly stimulates the MMC and gastric emptying. Rifaximin, a poorly absorbed antibiotic, can improve symptoms associated with MMC dysfunction, particularly in cases of small intestinal bacterial overgrowth (SIBO) and related conditions like IBS-D, by reducing methane production and modulating the gut microbiota.
Erythromicin Mechanism
Erythromycin acts as a motilin receptor agonist, stimulating the MMC and promoting gastric emptying. It induces premature MMCs at lower doses and can prolong their cycle length at higher doses.
Considerations: Erythromycin can cause side effects like diarrhea and nausea. It may also contribute to antibiotic resistance if used frequently.

Rifaximin Mechanism:
Rifaximin is a non-absorbable antibiotic that primarily acts within the gastrointestinal tract. It can reduce bacterial overgrowth, including methane-producing bacteria, which can be a factor in slow transit constipation.
Considerations: Rifaximin has a favorable safety profile with minimal systemic absorption and fewer side effects compared to other antibiotics.

Which to Choose?
The choice between erythromycin and rifaximin depends on the specific underlying cause of the "lazy" MMC and associated symptoms:
• If delayed gastric emptying is the primary issue:
Erythromycin is a good choice as a prokinetic agent to improve gastric motility and emptying.
• If SIBO, dysbiosis, or IBS-D are suspected or diagnosed:
Rifaximin is a good option to address bacterial overgrowth and related symptoms.
• In some cases, a combination of both might be considered:
For example, erythromycin could be used to improve gastric emptying, while rifaximin addresses SIBO.

LucH

Usual bacterial protocol
Unbalanced microbiota + excessive symptoms (irregular bowel movements, flatulence, gas)
See Dr. Antonio d’Oro for a full explanation to deal with a dysbiosis.
The distinction between fermentative and putrefactive dysbiosis is primarily made through gas odor, bowel movements, and specific biological tests:

Fermentative dysbiosis: The bacteria poorly break down carbohydrates (sugars). The gases produced are generally odorless, often associated with SIBO or IMO when the condition persists beyond 3 months.
Putrefactive dysbiosis (methane or hydrogen): The bacteria poorly break down proteins. The gases produced (ammonia, hydrogen sulfide, amines) are very foul-smelling (e.g., rotten egg smell), and bowel movements are generally slowed.
We have often to re-educate a lazy MMC (interprandial transit) and to clean the place.
*) Standard protocol
In short:
Resolor 0.5 mg (prucaloride) to stimulate transit. Re-education is required.
Resolor 0.5 mg + antibiotic (erythromycin and / or rifaximin)
Warning:
There may be a release of LPS toxins. It would be wise to learn how to support the liver and elimination organs to avoid panicking and unnecessarily increasing stress. Furthermore, nature abhors a vacuum (empty place). It would be wise to start planning how you will proceed after cleaning.

*) My protocol
The way to proceed is different if there is suspicion of candidiasis. We weaken the creature; we don't starve it, otherwise the price will be high. First weaken it, then beat it, and finally kill it with candida albicans.

In short:

No food after 8 PM.
Essential oils to clean the place.
NB1: We have to reach the second part of the colon. So a delayed action is required. EO caps must be gastro-resistant.
NB2: I think this not enough to simply try to kill the beast. We won’t kill all the bacteria (hidden behind an entero-film) waiting to come back, but with a stronger selection. I’ve based my decision on an already experienced protocol by a forum moderator of my forum (darky35 => now mentioned as “invited”)
a) Soft approach: Dysbiosis Aroma (Salvia nutrition): Purify – balance – strengthen.
b) My approach: weakened nutritional approach + EO. E.g. Now food: Oregano oil softgels 90x (with fennel and ginger); peppermint softgels 90x (with fennel and ginger). + Mountain savory in case of dysentery (Satureja montana ssp montana carvacrolifera).
The first 48 hours, I drink water (no chlorine) with EO diluted. Shake well before use as essential oils are not soluble in water without a base (alcohol, fat or sugar). Drink every 2 hours. Details on my forum. See link beneath.

Info on my forum, in French (translator needed):
*) Comment stimuler des intestins paresseux lorsque la motilité est insuffisante avec un prokinétique (How to stimulate sluggish bowels when motility is insufficient with a prokinetic)
https://mirzoune-ciboulette.forumactif.org/t2115-comment-stimuler-des-intestins-paresseux-lorsque-la-motilite-est-insuffisante-avec-un-prokinetique#30238
*) Liens de témoignages de forumeurs sur le SIBO (testimony on how to deal with)
https://mirzoune-ciboulette.forumactif.org/search?search_keywords=sibo+&typerecherche=interne&show_results=topics
*) SIBO : l’invasion des mauvaises bactéries dans votre intestin. Pullulation bactérienne. (SIBO: the invasion of bad bacteria in your gut. Bacterial overgrowth).
https://mirzoune-ciboulette.forumactif.org/t1131-sibo-pullulation-bacterienne?highlight=sibo
=> Article du Dr D’Oro.

The microbiota is the center of our immunity.
If you regularly suffer from bloating, belching, flatulence, gastric reflux, abdominal pain and/or diarrhea, or even unexplained fatigue, most of these problems originate in the small intestine, where there is an excess of bacteria (SIBO).
There is a close link between bacterial overgrowth and celiac disease (irritable bowel syndrome or IBS).
SIBO, FODMAPs, gluten sensitivity, lactose intolerance, etc., all contribute to low-grade inflammation of the intestinal mucosa. However, low-grade inflammation weakens leaky gut. This opens the door to an autoimmune reaction.
Understand the process that leads to intestinal permeability.
*) Comment traiter les Sibo avec prokinétique et HE (How to treat SIBO with prokinetics and essential oils)
https://mirzoune-ciboulette.forumactif.org/t1990-comment-traiter-le-sibo-sifo-avec-prokinetique-et-he?highlight=sibo
With specialists like Prof. Marc Pimentel, Dr. Bella Lindemans, Dr. Nirala Jacobi, etc.
*) Journal de suivi de Luc. Démangeaison et histamine (LucH's progress log. Itching and histamine problems).
https://mirzoune-ciboulette.forumactif.org/t1985-demangeaison-histamine-journal-de-suivi
*) Source of the Info on MMC (Migrant Motor Complex) (=> interprandial motility)
“The complexity of the relationships between motility, transit and absorption is mainly due to the numerous parameters which characterize an intestinal contraction and to the nature of the intestinal contents.” (1)

Role of motility in intestinal transit and absorption
J Fioramonti 1, L Buéno. Presse Med. 1989 Feb 15;18(6):249-54.
*) Mécanisme des prokinétiques
https://www.lanutrition-sante.ch/decouvrez-limportance-des-prokinetiques-dans-les-troubles-digestifs/

alfredoolivas

@lettheredeemed just found 9 5mg semaglutide vials stashed under the sink of the cold moldy bathroom (insert darth vader gif).

alfredoolivas

@LucH thanks I’ll read it !!

user1

@alfredoolivas said:

@sunsunsun I’ve been off for a year? That’s news? Not even trying to make a joke lol, I would have mentioned that I was taking them on this thread. My motility is too slow already, so I would be at greater risk of gastoparesis, I am not hyperphagic and there are anti dopamine side effects.

Thanks

Since when digestion is so slow? To much salt can contribute to reflux, worsen digestion and goods staying to long in your stomach, even more so if you intentionally try to lower high potassium. And magnesium foods

alfredoolivas

@user1 since April, after I tried meldonium twice