The anti-cortisol mechanism of trenbolone
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I think tren only cycles may be good, because OVX with tren was often more effective than tren by itself.
Lowering endogenous sex steroids like progesterone, estradiol and test WITH tren can be even more anti-lipolitc.
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@sunsunsun my inuition may be correct
@sunsunsun said in moggy chicken log:
@alfredoolivas but why u think androstane avoidance is le good
@alfredoolivas said in moggy chicken log:
@sunsunsun intuition
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@alfredoolivas y tho
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@sunsunsun What are your questions?
It's really effective in quite low doses. Heifer to HED dose is pretty similar. If 2.85mg of TBA a day (the estimated amount when they were slaughtered) had 28% less FAS, smaller fat cells or 700mcg doses having 63% less GR expression & less cortisol, 2mg having 75% less GR in rats. It also decreases FFA & Lipolysis in fat, whilst having these moderate fat loss effcts in these low doses, which is quite rare.
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Trenboloen decreases aromatase:
" The results indicated that 17β-trenbolone exposure decreased the number of primordial germ cells at 1 dpf and 3 dpf, decreased expression of ovarian differentiation-related genes foxl2 and cyp19a1a at 60 dpf, increased expression of testis differentiation-related genes dmrt1"
"Cyp19a1a (cytochrome P450, family 19, subfamily A, polypeptide 1a) is a crucial gene in teleost fish that encodes gonadal aromatase, an enzyme responsible for converting androgens into estrogens to drive ovarian development."
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@alfredoolivas are you using LDT right now to achieve moggy chicken?
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Decreases metabolic rate. This could be becayse they were eating less. T3 dropped by 0.3. So it doesn't cause fat loss by increasing metabolism. Mifeprestone also doesn't increase the metabolic rate and causes weight loss, so it could be due to supression of lipogenic pathways and less appetiete
Also found this interesting part
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"A combined implant of 17 beta-estradiol trenbolone acetate in young male goats decreased blood glucose and insulin 28 d after treatment, but had no effect on growth or thyroid hormones. No relation was found between hormonal concentrations and growth performance."
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Trenbolone greatly decreases corticosterone and ACTH, whreas testosterone increases it!!!
https://pubmed.ncbi.nlm.nih.gov/2170557/]]0.1296mg/kg HED.
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"Interestingly, potent anabolic steroid trenbolone bound to the glucocorticoid receptor with an affinity almost as high as that of corticosterone, the endogenous glucocorticoid in the rat " not cortisol ik
10.1016/0022-4731(86)90109-3 -
https://avmajournals.avma.org/view/journals/ajvr/52/2/ajvr.1991.52.02.282.xml?tab_body=pdf
Trenbolone derivative, via being a progestin, can treat endotoxinemia
"Evaluation of progesterone deficiency as a cause of fetal death in mares with experimentally induced endotoxemia"
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decreased cholesterol and FFA
10.2527/1993.71102659x -
It seems to decrease cholesterol, prolactin, increase heart rate slightly and temps remain neutral.
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Decreases desaturase enzymes (estradiol was added to too). Other studies show it increases SFA to MUFA ratio
10.2527/jas.2006-280 -
decreases beta 1, beta 3 adrenaline receptors but increase beta 2
10.1111/j.1439-0396.2007.00675.x
I hypothesise that it is adrenergic but anti cortisol, because of the study that suggested it was excitable and calcium handling may be altered
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It decreases brain aromatase
It increases ERb, but so does the aromatase inhibitor fedarazole
10.1897/08-082.1
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Increases gonad size
10.1016/j.marenvres.2009.09.009 -
"co-treatment with 17-TBOH and flutamide (an AR antagonist) also results in anti-estrogenic activity in female fathead minnows"
"17-TBOH, alone or in combination with 17- E2, has been shown to increase the cross-sectional area (CSA) of type I, but not type II, skeletal muscle fibers and induce a fiber switch from more glycolytic to more oxidative fibers, J.F. Yarrow et al. / Steroids 75 (2010) 377–389 381 indicating an increase in the oxidative capacity of skeletal muscle [152,189]. "
"As a result of its anti-glucocorticoid actions, 17-TBOH produces a more robust inhibition of protein degradation than does testosterone, which only slightly reduces protein degradation while increasing protein synthesis "
"Preliminary evidence from our laboratory indicates that the enanthate ester of 17-TBOH protects against hypogonadism induced cancellous bone loss to the same extent as supraphysiological testosterone
"In our hands, the lipolytic effects of 17-TBOH-enanthate are even more potent than that of supraphysiological testosterone-enanthate (unpublished laboratory results)"
10.1016/j.steroids.2010.01.019
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Trenbolone is a Carbonic Anhydrase Inhibitor
10.3109/14756366.2011.584535
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Decreases desaturase enzymes
10.2527/jas.2011-3496
