Estradiol increases binding of DHT in prostate two fold in vivo
-
Regulation of cytoplasmic dihydrotestosterone binding in dog prostate by 17 beta-estradiol.
"17 beta-estradiol enchances androgen-induced prostate growth in the castrate dog to a degree comparable to that seen in spontaneous prostatic hypertrophy. To investigate the mechanism of this synergism, cytosol androgen binding was measured by a density gradient technique in prostates of control and 17 beta-estradiol-treated castrate dogs. [3H]Dihydrotestosterone was bound principally to a moiety that averaged 8.6S in size. Approximately twofold enhancement of this binding by 17 beta-estradiol was demonstrable after 1 wk of treatment with 750 microgram/wk and after 3 wk with 75 microgram/wk. Under conditions in which binding in the 8S region was demonstrable with dihydrotestosterone and testosterone no binding of 3 alpha-androstanediol or progesterone was detectable. Thus, enhancement by 17 beta-estradiol of a prostate cytosol androgen-binding protein occurs under circumstances in which 17 beta-estradiol enhances androgen-mediated prostatic growth."
-
@alfredoolivas this is exactly why you don't want to plummet E2 too low with an AI.
-
@alfredoolivas this is exactly why you don't want to plummet E2 too low with an AI.
Really? So you can experience rapid prostrate growth to the point where it becomes problematic?
The whole point of this study was an attempt to replicate some of the conditions of BPH. The castrated dogs injected with estrogen may have seen tighter binding of DHT in the prostrate, but this isn't necessarily a good thing. The prostate may have been attempting to protect itself from a massive amount of stress hormone, and sucked up as much protective DHT as it could find.
Remember, these were freshly castrated dogs, and the all the dogs were sacrificed after six weeks, some much sooner. We don't know what would have happened had things progressed longer, but it's reasonable to to assume that DHT levels would have dropped and the effect of the supplemental estrogen would have been unopposed over a longer timeframe.
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login