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    The Mysterious Case of Pufa Depletion

    Scheduled Pinned Locked Moved Bioenergetics Discussion
    pufadietthyroiddnp
    74 Posts 10 Posters 3.6k Views 10 Watching
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    • E Offline
      evan.hinkle @TexugoDoMel
      last edited by

      @TexugoDoMel excellent response! Thank you

      H 1 Reply Last reply Reply Quote 0
      • H Offline
        hcwilliams @evan.hinkle
        last edited by

        @texugodomel @alfredoolivas and people of the thread . Is there any reason to believe that uncouplers , especially strong ones, will increase cortisol and or adrenaline

        alfredoolivasA TexugoDoMelT 2 Replies Last reply Reply Quote 0
        • alfredoolivasA Offline
          alfredoolivas @hcwilliams
          last edited by

          @hcwilliams yes of course

          H 1 Reply Last reply Reply Quote 0
          • TexugoDoMelT Offline
            TexugoDoMel @hcwilliams
            last edited by

            @hcwilliams Well, it uncouples from ATP production so yes.

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            • H Offline
              hcwilliams @alfredoolivas
              last edited by

              @alfredoolivas said:

              @hcwilliams yes of course

              Do you think tren is an uncoupler? Based on anecdotal evidence of night sweats, a need for carbs, and it’s fat burning ability?

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              • engineerE Offline
                engineer @TexugoDoMel
                last edited by

                @TexugoDoMel said:
                Regardless of the diet, the body converts almost all stearic acid into oleic acid. Since it is generally difficult to find an oleic-rich food that doesn't also contain excessive amounts of linoleic acid, the best approach I’ve found is direct stearic acid supplementation; this allows you to increase oleic acid levels in proportion to the amount of stearic supplemented while adding zero PUFAs.

                Looks like you can buy pure stearic acid from Amazon et al. right now for prices similar to coconut oil. Has anyone tried using stearic acid in lieu of coconut or other oils to maximally gain its benefits? This seems like the kind of thing you'd ask Ray but I haven't seen anything in the archives regarding this.

                alfredoolivasA 1 Reply Last reply Reply Quote 0
                • alfredoolivasA Offline
                  alfredoolivas @engineer
                  last edited by

                  @engineer seems there is vastly different absorption rates of different waxes. @texugodomel could maybe weight in on this. IIRC, one type has 15% absorption

                  engineerE 1 Reply Last reply Reply Quote 0
                  • engineerE Offline
                    engineer @alfredoolivas
                    last edited by

                    @alfredoolivas so are you saying that if you cooked with pure stearic acid, you'd absorb only 15% of it? in other words, you get a free total fat reduction, or are you talking about absorption in the pure form?

                    alfredoolivasA 1 Reply Last reply Reply Quote 0
                    • alfredoolivasA Offline
                      alfredoolivas @engineer
                      last edited by

                      @engineer “I'm not a fan of consuming stearic acid from manufactured sources. "The efficiency with which human subjects digest stearoyl from cocoa butter still remains uncertain, while the digestion of total long-chain fat from this source is 0.89-0.95 g/g, high in comparison with 0.33 g/g for Salatrim 23CA and 0.15 g/g for tristearin in their prepared states." https://pubmed.ncbi.nlm.nih.gov/19087439/. According to this study, stearic acid in cocoa butter is 89-95% absorb-able, while staric acid from tristearin is 15% absorb-able. The fireinabottle stearic acid is mainly tristearin. The cocoa butter stearic acid is mainly stearoyl“

                      I remember this Reddit comment that’s all. Yeah.

                      1 1 Reply Last reply Reply Quote 0
                      • H Offline
                        hcwilliams
                        last edited by

                        Alright I’m starting my journey to pufa depletion in a year. I crunched some numbers and, assuming my total pufa stores are around 35-45% of total fat weight, I figure I can get that down to 8% in a year.

                        It’s gonna consist of dropping my total body weight stores to about 10-11lb of total BW, or around 8-10% body fat, then purposely gaining weight with saturated fat, then dropping total body weight back down to 10-11lb.

                        Each time I drop my body weight my total pufa stores also go down in weight. Then Purposely adding fat mass to my frame will dilute the percentage of pufa stores. Rinse wash repeat.

                        I am Rays biggest Peater

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                        • 1 Offline
                          16characterstwas @alfredoolivas
                          last edited by

                          @alfredoolivas on the stearic acid issu i think I remember haidut citing studies and say ing it helped for himself but then later discovered he developed a tolerance-like thing for it, so it didn't work asmuch. I'll see if i can find those discussions

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                          • alfredoolivasA Offline
                            alfredoolivas
                            last edited by

                            @texugodomel you’re twitter got suspended? If you have a new account and would like shoutouts to regain your following let us know !

                            alfredoolivasA 1 Reply Last reply Reply Quote 0
                            • alfredoolivasA Offline
                              alfredoolivas @alfredoolivas
                              last edited by

                              I think I got your handle wrong mate, ignore me 😂✌️

                              1 Reply Last reply Reply Quote 1
                              • H Offline
                                hcwilliams
                                last edited by

                                @texugodomel I've been thinking about what you've said on this thread.

                                Despite my attempt at a quick dilution, will my cellular lipid structure maintain the same 2-6 year half life of pufa?

                                TexugoDoMelT 1 Reply Last reply Reply Quote 0
                                • TexugoDoMelT Offline
                                  TexugoDoMel @hcwilliams
                                  last edited by

                                  @hcwilliams

                                  No. This is an estimate extrapolated from another situation and is based on removing only PUFAs from the diet while keeping everything else the same.

                                  If you accelerate total weight loss, or accelerate it by other means, this “half-life rule” does not apply

                                  H 1 Reply Last reply Reply Quote 0
                                  • H Offline
                                    hcwilliams @TexugoDoMel
                                    last edited by

                                    @TexugoDoMel wow, the human body has incredible adaptation

                                    I wonder why, then, Ray expressed interest in personally supplementing with Dipalmitoylphosphatidylcholine (DPPC) and Distearoylphosphatidylcholine (DSPC) which help saturate lipid cardiolipin.

                                    ...Expressing interest far enough into his low pufa diet for it to have... negligible effects at best (?)

                                    alfredoolivasA TexugoDoMelT 2 Replies Last reply Reply Quote 0
                                    • alfredoolivasA Offline
                                      alfredoolivas @hcwilliams
                                      last edited by alfredoolivas

                                      @hcwilliams bro if you just ate extremely low fat and locked in with a calorie deficit, you would of dropped a percentage in LA bodyfat by now, just do it and stop overthinking. Don’t be lazy

                                      H 1 Reply Last reply Reply Quote 0
                                      • H Offline
                                        hcwilliams @alfredoolivas
                                        last edited by

                                        @alfredoolivas bro I’m just asking questions

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                                        • TexugoDoMelT Offline
                                          TexugoDoMel @hcwilliams
                                          last edited by TexugoDoMel

                                          @hcwilliams

                                          Ray recommended the slow approach.

                                          -Remove PUFAs from the diet
                                          -More carbs
                                          -Antilipolytics (B3, aspirin, etc.)
                                          -Other “saturators” (such as policosanol and perhaps the ones you mentioned)
                                          -T3 supplementation(which has a PUFA-depleting effect when you've already limited them in your diet)

                                          That way, you limited the PUFAs’ access to the mitochondria and could safely eliminate them through glucuronidation.

                                          The effect is the same as what I mentioned in one of my earlier comments. If a sample were taken, the tissues would have very low levels of PUFAs, so you could eliminate them in a controlled manner, which isn’t the case for most peaters, since losing fat isn’t really a concern for most of them. In that case, every time too much stored PUFAs were released, the situation would change.

                                          If someone has the patience to wait 4–6 years for that, I don't see why they shouldn't plan for gradual weight loss as well. You can easily lose 10–20 kg over that time without even worrying about it. Peaters madness

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                                          • H Offline
                                            hcwilliams
                                            last edited by hcwilliams

                                            @alfredoolivas @texugodomel ive been digging thru some of yalls posts and twitter and it looks like im not the only one on this pufa depletion journey lol

                                            Screenshot 2026-09-28 at 11.50.27 PM.png

                                            can someone explain whats going on with this fella here^^? seems like he would be pretty saturated by now? is he on thyroid medication?

                                            H TexugoDoMelT 2 Replies Last reply Reply Quote 0

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