@Fructose Additionally, the notion of maintaining a constant equilibrium in a complex system is open to question. The system is in a state of constant fluctuation, moving in and out of equilibrium. Consequently, the assumption of true equilibrium may be invalid. The equilibrium of a complex system can be readily disrupted by a multitude of factors.

With regard to CO2, it seems plausible that it functions as a stock-flow principle, analogous to a process such as pregnenolone from a technical standpoint. The body accumulates CO₂ to an optimal level, thereby facilitating the attainment of equilibrium within the system. Furthermore, evidence suggests that CO₂ is sequestered in bones, which lends support to the hypothesis that the body is constantly striving to maintain an optimal level of CO₂ within the system.

@LucH Yes i know about the toxic effects of estrogen and further cascades. I was just curious about this and see if i understand things correctly.

In the paper they mention decreased dihydroorotate dehydrogenase expression (after OVX), so estrogen should increase the activity of it. Dihydroorotate dehydrogenase catalyzes ubiquinon to ubiquinol and a reduced pool of ubiquinon is a marker of Reverse Electron Transport (RET). The RET leads to an increased ROS production, which leads, depending on the fatty acid structure (saturated vs. unsaturated) to more lipid peroxidation.

So if i understand this correctly, how on earth should estrogen be helpful in this situation? It should rather be toxic given the above mentioned information.

Hey,
I am seeking an explanation or insight into this paper. https://pubmed.ncbi.nlm.nih.gov/37116254/

How can estrogen protect against lipid peroxidation and alleviated ferroptosis? Ray said in his newsletter "Estrogen, iron, degenerative
aging, and progesterone" that high estrogen leads to iron accumulation, which could cause lipid peroxidation.

Hello,
Has anyone thought about using the system dynamics approach to model Peat's ideas on endocrinology, the Randle cycle, etc. ? I'm just wondering if it's a useful way to visualize the ideas.