Oof okay, DHT’s 3-keto can’t be esterified without reducing it, and thatd just tank its activity, I kno im retarded but the responses here are just dogmatic lecturing “take your test and shut up.” It’s condescending and kills any real discussion. I’m not trying to just follow the same old path everyone’s been on since the 50s.where’s the progress?? if you’re not open to exploring new ideas why even engage??

@alfredoolivas do you think changing the position of the ester to 3a or 3b cause it to cleave slower? Or maybe a double ester

@alfredoolivas adamantyl steroids are less hepatotoxic and have fewer sides than most esters, which could let you dose higher safely. So even if the release is slower, you might still get more total exposure over time. I’m also scratching my head at the study, how can the half-life of adamantyl be shorter compared to other steroids when we know the adamantane ring is so stubborn to metabolize on its own? A 2012 study in Steroids (Vol. 77, Issue 5) noted that “adamantane derivatives exhibit remarkable stability against enzymatic degradation, often extending half-lives significantly” (p. 419). Maybe the dosing or assay setup skewed things here?

been kicking around this crazy thought after digging into some old papers, what if you took something like androsterone, or even DHT, and stuck an adamantyl ester on the 3α spot? That bulky adamantane chunk could stretch the half-life out crazy long, maybe 8 weeks or more.

It has to be androsterone for this, it’s cheap, easily sourced, and I like that GABA calming thing it does, plus the pheromone angle. With the adamantly ester we'd be looking at a biological half life of days, or even weeks! The slow release is what’s got me hooked on this idea, could stack up effects without torching your liver like orals do.

If we used DHT instead results would be insane, 5-10x testosterone’s kick, no estrogen mess, but creating a novel steroid that would likely put most pharma steroids to shame would be taking some serious heat

My main concerns would be a prolonged GABA "buzz" if you take it everyday, the fact that it takes so long to clear out the body makes testing slightly dangerous.

Thoughts?

https://pubmed.ncbi.nlm.nih.gov/5867938/

https://en.m.wikipedia.org/wiki/Bolmantalate