Posts made by Kat

I run HTMA tests and generally do not recommend to chelate metals unless drainage pathways are open. I support which elements/minerals are displaced by the heavy metals (based on the test results) by increasing them in the diet and possibly with supplementation based on the individual. I do use gentle binders to help with elimination but not strong chelators.

@Samyo have you dont any food sensitivity testing? Sounds to me like you have a histamine response and have a food sensitivity to mushrooms likely due to intestinal permeability. Histamine will interfere with sleep it binds to H1 receptors and H3 in the brain and decreases acetylcholine signaling interfering with REM sleep and it is also a neurotransmitter which promotes wakefulness so will keep you up. It is why anti-histamines make us drowsy they interfere with histamine binding to H1 in the brain.
I would say you should run a GI MAP, find out what is going on in your gut, run a food sensitivity test and find out what you are sensitive to (other than mushrooms which is clear) and get an OAT (organic acids test) to identify any other possible stressors contributing to your symptoms (which I am sure there are more this reaction is not the only one). HTMA would be helpful here since minerals play a key role and sounds lik your mineral balancing is skewed, esp with the skin sx and immune sx. Once you know what foods you are reactive to you can remove them for 90 days, you can optimize your gut health and intestinal flora and get rid of any pathogens identified in the testing, and address any imbalances found on the OAT. Then your clear immune flares to certain foods and imbalances will likely clear up.

Hi! I am just curious if anyone wants to explain Haidut's views on autoimmunity. I understand that there are some main mechanisms that can contribute to 'autoimmunity' which I think is really that the body has immune dysregulation due to a chronic stressor more than it is 'auto'. But this is my understanding: 1. Chronic inflammation leading to DAMPs and immune response responding accordingly however due to continued stimulus the DAMPs continue to be made and so tissue continues to be attacked, inflammation increases, and more DAMP and ROS production stimulating immune function further due to RAGE activation. This either contributes to gut inflammation or further dysbiosis there, which then activates further systemic inflammation via damaged tight junctions and LPS and further immune response. The intestinal permeability seems to be a prerequisite to me for any autoimmune reaction and failure of self recognition systems to maintain central and peripheral tolerance. Treg cells decrease due to increased IL-6 and Th17 cells are produced in higher numbers and histamine is constitutively being produced from chronic activation of mast cells. 2. this environment damages MHC class I complexes which then cause the immune cells to destroy those cells as they are indicating cellular damage. 3. Molecular mimicry - pathogenic presence such as prevotella, klebsiella, proteus, h pylori etc have similar structure to our own tissues and in the systemic inflammatory environment the ability to distinguish between self and non self when they are so closely similar is not able to be maintained and the immune system produces both Ta nd B cells which recognize self tissues. Gliadin can also be a main contributor here and has molecular similarity to many structures in the body including synapisn I, TPO, cartilage etc.
I understand that in the bioenergetic view and Haidut's view (of which I am a HUGE fan - I have learned so much from his work am super grateful and for his idealabs products) that autoimmunity in the current medical view is seen as 'idiotic' and that molecular mimicry does not play a role in these hyperinflamed conditions. I wanted to know what the view is of what is really happening, and if if molecular mimicry is not something that is considered to be occurring? Is it mostly DAMP activation that is thought to be happening? I have just seen a lot of literature about the molecular mimicry and though not a driving factor I think it does play a role and that the hyperinflamed environment leads to immune dysregulation at many points. I think the key is to restore gut barrier, eliminate pathogenic overgrowths or presence, and remove all stressors that are contributing to the chronic inflammation. I would love to hear some perspectives on this. Thank you!

Hi! I am curious if anyone has experience with looking at hyperthyroidism and osteoporosis? I have been looking into calcium metabolism and thyroid function to try and identify where a healing opportunity may be in an individual to get balance back to thyroid and thus calcium levels. It seems to me that supporting Ca regulation with K2 M4 would be beneficial, taking molecular hydrogen or MB to help with oxidative stress that may be occurring from TPO activation, and taking progesterone and DHEA to help with possible hormonal imbalances to counteract estrogen and cortisol which I would assume to be elevated in such a condition. This would have to come along with a diet that supports bioenergetic metabolism of course first and foremost. Does anyone have any thoughts on this? Is there a mechanism I should be aware of or relationship that could be involved here that would also be clear to address (I know PTH would also cause Ca levels to become high but addressing the cortisol and estrogen would likely help to support proper PTH balance?). Thanks for anyone who has thoughts on this!