@sushi_is_cringe wtf crazy plot twist! Now everything makes more sense. Here I was thinking I was taking to some obese dude who couldn't put the fork down. Now the reason for his appetite struggles and poor response to thyroid are clear. Like hitting the gas pedal with no fuel.

Alfredo, I hope you come to realize you don't need all those drugs to maintain a killer physique. Seriously, you don't want to end up like Zyzz.

@alfredoolivas Touched a nerve? You can do as you please with your body. I didn't diagnose you, I only said it appears you have thyroid hormone resistance if you think you need 300mcgs. It's not healthy and would put your blood levels of T3 far far beyond the upper end of normal.

I wrote what I did in the spirit of harm reduction. I think extreme doses of thyroid is ill-advised and potentially life threatening and I'm certain everyone here would agree that Dr. Peat would have opposed the idea.

I recommended an endo that's cool with NDT because the ones that aren't are usually only test tsh and prescribe synthroid. They might even prescribe ozempic so you wouldn't have to inject some sus product from China. I also think it's wise to consult with someone who has experience in the field and who can run blood tests and provide feedback if you're going to monkey around with hormones.

Again, best of luck

He clearly failed to "detox" thoroughly before trying the official Ray Peat diet.

What issues was/is he having? I know he would bounce around from extreme to extreme but I don't remember what he was trying to cure. Whatever it is must be pretty severe.

@alfredoolivas Do whatever you want. Stack DNP, clenbuterol, orlistat, cloprostenol, or any other drug that you find positive studies on. Why not even bump your T3 dose up to 1mg a day since you don't believe it's cardiotoxic. Elite bodybuilders very rarely exceed 150mcg but they aren't nearly as advanced as you.

I really don't care what you do or think I just don't want anyone to believe it's OK to dose that high because you, an individual with apparent thyroid hormone resistance, posted the abstracts of a few studies and claimed to have done it without issue. There are a whole litany of side effects: tachycardia and palpitations, along with jitters and nervousness, are the most prominent. Hypertension, angina, muscle weakness, insomnia, diarrhea, sky high SHBG, and sweating are some others. Fortunately I don't think anyone with an intact sense of self-preservation is going to listen to you.

Since you put so much faith in studies, why don't you adopt the keto diet? Plenty of studies show its efficacy in appetite suppression and weight loss.

Wow, you're the Ray Peat subreddit mod? Lmao! Ray Peat would have spat out his coffee if he had heard someone was running a forum under his name promoting all the drugs you do.

One day you're going to look back with regret for putting all this shit in your body. I know you won't listen but my parting words of advice are to consider working with an endocrinologist that's willing to prescribe NDT.

Good luck

@alfredoolivas So you lack the willpower and discipline to overcome your hunger during a cut and therefore need to take a novel big pharma drug? Got it.

No matter how much or by what means you boost your metabolism, you're going to lose muscle mass if your metabolic rate exceeds the rate at which your body is able to mobilize stored lipids. Same goes for simple calorie restriction. I don't know if this is the cause of the reported muscle loss on ozempic. It could be something else causing it. All I know is that the people I've seen that have lost weight on ozempic don't look quite right.

You mean your experience with a weak or fake product? Try it again with cynomel if you dare. One study using metabolically-deranged mega fatties does not concretely prove your point. Do you not believe in thyrotoxicosis? What about thyroid storm? Mere superstition from overly cautious endocrinologists, right? I've known people who have experienced thyrotoxicosis and they all found it quite scary. Perhaps you should meet with an endocrinologist yourself if you believe you're truly hypothyroid. That way you could have labs done and ensure you get genuine hormones.

Before singing the praises of semaglutide, don't you think you ought to achieve your goal weight first and maintain it a good while after discontinuing?

@alfredoolivas Testosterone is for favorable nutrient partitioning and lean mass preservation as you said. T3 absolutely will ramp up fat loss, beyond just the maintenance of the normal metabolic rate in a deficit, as long as you don't out eat the metabolic boost. I've seen it work first hand in others. Done right, it's a gradual thing but so is any lasting weight loss. Muscle loss isn't really a concern with proper diet and training so long as you aren't seriously overdosing.

If you took 300mcg for a few days without your heart beating out of your chest and without severe jitters then you either have really weak product or some sort of thyroid hormone resistance. 300mcg is reckless and advise anyone reading this not to try it.

And for the record, there were multiple reports on the old RPF that tironene is unstable or outright bunk. Since you're taking it you could have some blood work drawn to verify if you're curious. At 100mcg a day your total T3 level should be more than double the top of the range.

Anyway, good luck with your weight loss goals and your biohacking experiments.

@alfredoolivas They absolutely do in supraphysiological doses. Try perusing some bodybuilder forums. I wouldn't recommend you try high t3 though as it will send your appetite through the roof.

Yes, yes 3500cal in a pound of fat, assuming that you burn it exclusively. Is ozempic known to preserve lean mass and bone density compared to a solid exercise and diet plan alone?

@alfredoolivas I'm pretty certain semaglutide increased WAT along with brown. If you feel comfortable taking it then don't let me stop you. My point of contention is that the long term effects aren't fully known and rebound upon discontinuation is a real possibility.

How could testosterone and T3 not work on you? Sounds like a dosage or authenticity issue

Wow, that's a lot of drugs. I'd like to see your medicine cabinet lol. I don't know why you'd even consider ozempic as a weight loss shortcut when you've got t3 and testosterone on your list. Hell, I'd take DNP over semaglutide without second thought if I was desperate enough to lose weight.

Besides the side effects listed by Novo Nordisk and the media coverage of ozempic face and gastroparalysis, semaglutide sets you up for serious rebound. Some people even find that it stops working while you're on it. I'll have to dig up the study I found a while ago that showed that semaglutide prevented existing fat cells from storing lipids while causing a proliferation of new fat cells. Sounds like a recipe for disaster to me.

Have you tried drinking more coffee? I always feel my sharpest after a couple of espresso shots alongside a hearty breakfast.