@jimmynelson said:
When I was on cyproheptadine (very low doses) for a couple months I ate like a monster but I did have resolution of some long standing issues which I think were being held up in "healing" by stress hormones.
What was this "very low dose?" When I first experimented with cypro, I tried doing 1mg per day. I only lasted a couple of weeks, as I had this zombie like tiredness that would persist for most of the morning. Might just have been very tired in general all day, can't really remember. I stopped, and things got back to normal.
Later, I decided I would use some higher doses (starting at 4mg, going up to 8mg) and thought I would just push through the tiredness, however long it was. To my surprise, it was much milder this time, and only lasted about 3 days or so. After a while, some doses of cypro actually gave energy.
I think there is something to an initial "loading dose." Others on the old RPF mentioned the same sort of thing, that 4-8 mg as a starting dose caused minimal tiredness, but 1 mg caused much more tiredness. I think some suggested cutting back to 1mg after a week or two of loading, but I just kept it at 4-8mg, and saw good results. I think one RPF member even said Dr. Peat recommended a loading dose protocol similar to this, but I never saw or heard any direct quote from Peat in this regard.
Another potential option is selegiline. It's an MAO-B inhibitor, so it prevents the breakdown of dopamine, as opposed to being a Dopamine Agonist.