@jamezb46 said in GABA powder:

The heart and digestive system both have GABA receptors, so even if oral GABA is not CNS-penetrant, who cares?

I'd like to try to put the ball back in the center.
The question is not to know/ confirm that GABA powder can or not cross the BBB, nor whether there are GABA receptors in the gastrointestinal tract and in the muscles (cardiomyocytes and the cardiac conduction system). Yes, there are some.
The main question here is that there is interaction between the microbiome and the vagus nerve. We know butyrate is a substitute for several strains.
Butyrate is the star among SCFAs (with propionate) as it upregulates the tight junction proteins (occludin, claudin-1 and -4and ZO-1 (zonulin): Tight junction expression, anti-inflammatory signaling (via HDAC inhibition) and hypoxic barrier maintenance (via oxygen consumption in colonocytes). Butyrate literally energizes the gut barrier.
So if we accept that the GABA shunt is a pathway for enhancing a well-balanced microbiota, no need to know / confirm that GABA powder can or cannot cross the BBB.
GABA → Succinate = substrate for some bacteria that convert it into butyrate, a key SCFA.
But we should know how and when to use GABA powder.
More info:
How is GABA powder useful for microbiota?
GABA → succinate → butyrate pathway: The Microbial Power Route.
How gut bacteria convert GABA through the shunt and succinate pathway to fuel and protect colonocytes of the linen walls
https://mirzoune-ciboulette.forumactif.org/t2153-english-corner-how-is-gaba-powder-useful-for-microbiota#30480

@jamezb46 said in pre workout / intra / post workout:

@BioEclectic Why do you think lactic acid produces DOMS?

From what i had read at the old RPF forum, though i always hold open the possibility that i have either misconstrued or misremembered whatever i had read.

Not sure if this applies but I do know it noticeably reduces work or shoe related foot soreness. Mag sulfate and Mag bicarbonate.

@alfredoolivas Im tryna apply it on my balls and this is where the issues actually come from not from drinking it

@ThinPicking yeah, I might try this. I think it has to do with the antipsychotics but they won’t do anything.
The only thing that makes me deeply sleep is the benzodiazepine Ativan/temesta.

the addition of whey protein to my diet seems to be promoting leanness

@beriberi least racially self-hating South American

@jamezb46
I agree that lean is the way to go, but achieving fat loss requires that fat be metabolized for energy when in said deficit. I don't know if aspirin may cause a great slowing of this by keeping the switch turned to carb burning.

I'm also not sure how much of a deficit is safe without causing issues with thyroid and stress hormones, but that's a whole story I suppose.

you need thiamine for oxidative metabolism not just t3, thiamine deficiency and hypothyroidism have identical symptoms, t3 uses thiamine alot faster so these studies may just be inducing beriberi

@Ecstatic_Hamster BTW, this is private, memories are stored on your device or encrypted if you choose to sync, so nobody can ever see them.

@LucH -Thanks for your cautionary words.

@evan-hinkle said in Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults:

There was one in particular that was mentioned at a dose of 80mg, (so it seemed like the researchers thought it was particularly significant).

I would not put too much credence in 80 mg. The study below shows that 70% cocoa dark chocolate consumption can benefit verbal episodic memory two hours post consumption in healthy young adults relative to a white chocolate control. These findings support the notion that everyday available portions (35 g or 35,000 mg) of dark chocolate can confer benefits to the brain in healthy consumers.

Beneficial Effects of Dark Chocolate for Episodic Memory in Healthy Young Adults: A Parallel-Groups Acute Intervention with a White Chocolate Control (2020)

I suspect that the 80mg was used for safety reasons. Perhaps to get the study approved. 🙄

This thread from the former RPF has some interesting links related to choline.

https://lowtoxinforum.com/threads/choline-an-essential-nutrient-for-public-health-that-were-not-getting-enough-of-in-our-diet.47355/

@engineer

No
Don’t bump up

In fact
Why taking isolated?
Food first
And if taking a singular vitamin or mineral
You should take judiciously and therapeutically for a very limited time

Taking something in such a dose -unnaturally -sets you up to throw yourself out of balance