Useful info on magnesium:
High-Dose Vitamin D Depletes Magnesium – Carolyn DEAN, MD ND.
https://mirzoune-ciboulette.forumactif.org/t2130-dynamique-entre-vitamine-d-magnesium-et-calcium#30339

Excerpt 1:
Magnesium expert Andrea Rosanoff, Ph.D., is one of the few people who understands the dynamic between vitamin D, magnesium, and calcium. She makes it the subject of her 2016 article, “Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?”

Excerpt 2:
Magnesium is required for many steps in vitamin D metabolism, including its conversion from its storage form (which is also the supplement form) to its active form. This means that taking extremely high doses of vitamin D can lead to magnesium deficiency without anyone realizing it.

@heyman said in Literature Review @haidut:

Pretty insane spamming imo

Nothing compared to 'ai' twitter.

Glycine inhibitory effects
http://raypeat.com/articles/articles/gelatin.shtml
Glycine's inhibitory effects appear to oppose estrogen's actions generally, in sensory and motor nerves, in regulating angiogenesis, and in modulating the cytokines and "chemokines" that are involved in so many inflammatory and degenerative diseases, especially tumor necrosis factor (TNF), nitric oxide (NO), and prostaglandins. Exposure to estrogen early in life can affect the health in adulthood, and so can an early deficiency of glycine. The degenerative diseases can begin in the earliest years of life, but because aging, like growth, is a developmental process, it's never too late to start the corrective process.

From the article “Gelatin, stress, longevity”. Ray Peat. 2009
http://raypeat.com/articles/articles/gelatin.shtml
The relief of pain and inflammation is likely to be almost immediate, resembling the anti-inflammatory effect of cortisol or aspirin.
A daily intake of 100 grams of gelatin wouldn't seem unreasonable, and some people find that quantities in that range help to decrease fatigue.
If a person eats a large serving of meat, it's probably helpful to have 5 or 10 grams of gelatin at approximately the same time, so that the amino acids enter the blood stream in balance.

@haidut said in Glaucoma may be a metabolic condition, vitamin B1 (thiamine) may treat it:

The study below adds more evidence to the claim that glaucoma is a metabolic condition, by showing that vitamin B1 levels are low in glaucoma patients that supplementation with vitamin B1 (and/or agmatine, another pro-metabolic substance) may treat the condition. This suggests that vitamin B1 and B3, being highly water-soluble, may make a good eye-drop product for treating a number of eye conditions, by improving (glucose) metabolism (which is their primary role) both locally in the eye and systemically.

Thank you for the study, Haidut; and glad to see you posting here. Can it be assumed adding agmatine to these drops would be beneficial as well?

If time allows, I would be curious as to your thoughts on recipe ratios, storage, and lifespan when making these drops homemade: all ingredients mixed in water.

@haidut
Thanks a lot for this and all the other posts, we missed you so much! I read the paper and even though the authors claim that the purpose of sleep is to dissipate electrons, I struggle to get if they have really proven that. With their manipulations, I think they clearly showed what Dr Peat always said that sleep is an energy demanding process. What do you think? Nevertheless I agree that it is probably a way to antagonise electron leakage from fat metabolism.

If you are considering supplementing with DHEA: here is a reminder

Peatbot.com: Young people produce about 12 to 15 milligrams of DHEA per day. This amount decreases by about 2 mg per day for every decade after the age of 30. By the age of 50, about 4 mg of DHEA per day is usually sufficient to restore the level of DHEA in the blood to a youthful level. In old age, the production of DHEA decreases significantly, to about 5% of the levels produced in youth.

Peatbot.com: Taking supraphysiological levels of DHEA long term can lead to several adverse effects. One potential issue is the enlargement of the liver, as DHEA can stimulate liver growth and is highly carcinogenic to the liver. It can also cause an increase in estrogen levels, which may lead to an imbalance in hormone levels and associated side effects. In some cases, this can result in liver problems and an increased risk of liver cancer. Additionally, excessive DHEA can lead to masculinizing effects in women, such as the growth of facial hair. It is important to avoid taking more DHEA than needed, as excess amounts can disturb the function of the thymus gland and the liver.