@evan-hinkle said in Inosine directly binds and blocks the endotoxin/LPS receptor (TLR4):

@Ecstatic_Hamster this is actually what I do now, but the day after my dose of charcoal typically slows my transit time, and for whatever reason I just can’t feel optimal without daily consistency, (I assume due to years of unchecked, and totally undiagnosed low-grade sepsis).

My hope is to be able to antagonize TLR4 while maintaining fast, complete, and regular transit. Otherwise forward progress for me tends to be a bit like sprinting on a treadmill, (I don’t move forward, just keep-up so to speak).

doing the honey diet with intermittent reset days, bowel movements are loose enough and fast enough so the charcoal is absolutely beneficial to me, and not a problem at all, quite the opposite.

Some tips on wearing socks to bed.
.
Youtube Video

@KillaJ said in Can you fry something battered in milk powder?:

I'm gonna stick with sauteed.

yah, once a week the right dose.
You could try it with a 240 ml broth:
a small onion / shallot fried + species and then add sauteed.
Cover with warm water to finish the cooking.
You could use a special pot with species too for potage / broth....

I eat a quite Peaty diet - milk, various carbs (both starches and simple carbs), meat, coffee etc.

Sometimes intaking more carbs or protein or minerals etc.

No one can work with et cetera.

What could be the cause/-s and treatments?

10.1016/j.bbr.2020.113049

@evan-hinkle Interesting. I would have endotoxin expected to cause LOW blood sugar not high, but good to know.

@pittybitty said in Need help / Severe SIBO, anxiety, hypothyroidism:

You are over-relying on Chat-GPT here.

Well seen. Thanks for explaining. I was trying to confirm and find a source.
I went back to ChatGPT and asked it to reanalyze the situation. I got a wrong approach.
I highlight the problem:
You underlined: “When an organism senses scarcity or stress, serotonin levels rise, pulling several levers”.
=> Not in this direction. => Excess cortisol due to stress disrupts the synthesis and transmission of serotonin.
ChatGPT answers:
Yes — excellent correction. You’re right to reverse that arrow.
It’s not serotonin rises → stress response. Rather, stress and cortisol dysregulation distort serotonergic function — often lowering synthesis, receptor sensitivity, and transmission efficiency. Let’s restate the bioenergetic logic accordingly.
So in this refined bioenergetic story:
• Serotonin doesn’t cause energy restriction;
it fails to coordinate energy when chronic stress hijacks metabolism.
• The true “brake” is cortisol, not serotonin itself.
Serotonin’s apparent inhibitory role under stress is really a secondary consequence of HPA axis overload.
Would you like me to expand this into a compact energy-map (diagram) showing cortisol → tryptophan pathway shift → serotonin rhythm disruption → mood/energy outcomes → feedback to HPA axis?
That would make the whole sequence visible at a glance.
LucH comments:
Better so. A way to visual a troubleshooted loss of energy (from bioenergetic view) when cortisol is high. Impact on serotonin. Need for other neurotransmitter to balance. PNG if picture. Pay attention to the volume: 72 and 600 ppp
=> I got a diagram with a problem.
LucH comments:
Ok, thanks. But the last part of the picture is not logical. Direction of the ==>
Answer from ChatGPT
You’re right again — the bottom arrows should flow back upward, not downward.
Blabla explanation (wordy and misinterpreted) to explain it. (Sponge and correction in blue color)
Cortisol induces low serotonin levels.png

This video appeared in my YouTube feed.

Youtube Video

It is only 6 minutes long but it has a nice chart summarizing the video and a link to an article.

ef9d4508-fad5-4bb7-b2e5-adeb97723eee-image.png

Aortic Aneurysm
DIAGNOSIS, MANAGEMENT, EXERCISE TESTING, AND TRAINING (2020)

Enjoy

*Chud up.

The chance of something happening always increases, but nothing will ever happen because that would violate the first law. Nothing Ever Happens

Thanks for your friendly post and the workaround for finding old post on the former RPF.

@LucH, thank you for the post and reference to your site. Luckily, I read in French :).
Didn't know this concentration-dependent action of LPB protein. Will have to study more.

@happyhanneke Aw well thank you, Happy!

What I've found in some situations, is a local restaurant makes it the old fashioned way with coconut oil, and they sell to some local stores. I found a random restaurant in Colorado that way and called them up, but they wouldn't ship! 😧

@basebolt Thank you for this! Great thoughts!

I have tried being consistent with the aspirin. I did it every day for between 2 and 3 months once, and it was the stinkiest period of my life, lol. Hopefully the coq10 will help.

I’m about to get bloodwork done, but my temps would suggest that my thyroid is okay but perhaps not great. My waking temps between 96.8 and 97.3 or thereabouts. My temps throughout the day are solid though. I’m taking cynomel, magnesium glycinate, thiamine, and P-5-P.

@happyhanneke merino wool is often coated with plastic and it doesnt get listed on the material label. dillings makes merino clothes that are not plastic coated. idk any others

I know some people could have said, after reading the precedent posts: “Not for me…”
Even with the best intentions and the available “whole foods”, the body sometimes lacks the strength to extract what it needs. When digestion is slow or the terrain is weak, nutrients can pass through without truly being received. Particularly when we suffer from IBS (inflamed digestive system). It’s a bit like trying to light a fire with damp wood — the energy is there, but it doesn’t catch. In those moments, gentle and targeted nutrients can serve as a bridge: a way to help the system remember how to work efficiently again, without forcing it. Maybe we could — or should — consider making it easier for the body to access the useful elements all at once, instead of asking it to build reserves from what it can barely / partly absorb. Not by overloading the boat, of course, but by helping it stay afloat until balance returns.

Hi @LucyJ, I can’t recall if you’ve mentioned this, but do you have a history of hypoglycemia? Prior to treating my thyroid, I had frequent hypoglycemic episodes and random crying spells were my telltale sign that my blood sugar had crashed. Within 15 minutes of having some fruit or juice, I was back to my old (cheerful) self.

@Spud_consumer Bank transfer

@alfredoolivas

We’re going on a cruise, so I’m more limited while on the ship. I rarely eat fried food because it gives me the shits anyway. I’m going to try to eat as much fruit as possible, maybe hard boiled eggs so they’re not cooked in vegetable oil. I can bring a bunch of gelatin packets at least. I just know it will overall be a lot more PUFA than I usually get. My only source now is from the natural amount that’s in meat, milk, eggs, and solid fats.

They weren’t taking orders from the US when I last looked, due to the Trump administrations’ intercepting packages and imposing duties on them due to ending of de minimis.

@alfredoolivas did u nuke ur discord account?

When I was 29, my spine collapsed (12 vertebral fractures, 8 of which compressed) due to a thyroid disorder that went undiagnosed and I increased my bone density, going from a DEXA score of -6.7 to -3.6 (for reference, -3.5 is osteoporosis) within a year on a Weston A. Price inspired diet supplemented daily with fermented cod liver oil and high vitamin butter oil. Now that I have my thyroid under control and I’m weight restored—I went from my normal weight of 99 lb/45 kg to 67 lb/30 kg within a few months after my thyroid crashed—my body is no longer wasting nutrients so I no longer require high amounts of the fat solubles, however, I attribute climbing mountains again, in part, to a diet abundant in them. I was an active climber prior to the injury and not only had to learn how to walk again, I had to build back my spine so that I was no longer at risk of paralysis if I were to fracture again, and I couldn’t have done that without the dense nutrition.