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    Mild Vitamin A deficiency decreases DHEA and Pregnenolone by 40%

    Literature Review
    vitamin a dhea pregnenolone
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    • sphenoidS
      sphenoid
      last edited by

      So the euphoria/mania people experience on low A is the result of cortisol/estrogen/serotonin. Makes sense considering the live case study we’ve been witnessing.

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      • JulofEnochJ
        JulofEnoch @Mauritio
        last edited by

        @Mauritio

        Ich danke Ihnen für diese Studie und den Link zum Artikel.

        Greift nur hinein ins volle Menschenleben! Ein jeder lebt's, nicht vielen ist's bekannt, und wo ihr's packt, da ist's interessant.

        Ray Peat first-ever interview(July 1987 on UofO Student Radio)

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        • brightsideB
          brightside @Kvothe
          last edited by

          @Kvothe lmao

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          • L
            Lizb @Mulloch94
            last edited by

            @Mulloch94 thank you for your note on cholesterol.

            Buteyko:-

            I'm glad I have learned minimal, belly nasal breathing.

            I believe it has helped me avoid chest infections (I have bronchitasis).

            I know now how to pace myself and when to stop and slow down.

            It's the cleansing reactions that gave me difficulty and if I was doing it again I would choose a practitioner who had a gentler approach.

            My cleansing reactions:-

            It felt like an assault on my body

            • leaving me on the sofa for four days, for a day sometimes,

            -sleepless nights,

            • very weak, inability to do simple tasks because I just didn't have the breath to do them.

            • horrible mood

            The practitioner kept pushing and pushing me in order to experience these reactions.

            I honestly think that someone with bronchiectasis shouldn't be going into the realms of cleansing reactions and the pushing to hold the breath to extreme difficulty.

            I have experienced some amazing results with buteyko on occasion:-

            • tolerating very hot weather and being able to be working out in the sun without any difficulty.

            • walking up many steps, steep slopes as if I was walking on the flat (blew my mind that one)

            M 1 Reply Last reply Reply Quote 0
            • M
              Mulloch94 @Lizb
              last edited by

              @Lizb Thanks for the insights. I haven't been doing mine long, only about 5 weeks now. But it's became a viable replacement for bag breathing, which I never really cared for anyways. I'm still confused about all the various methods. For example, I've been doing the "breathe light" method and the "nose hold" method. I actually temporarily stopped these past few days due to a sickness I had, my nose and sinuses were stuffed, and it wouldn't have made for a very therapeutic experience. But hopefully I can start back tomorrow. It was really a breakthrough when I first started, helping me with my chronic hyperventilation (along with thyroid supplementation). I'm not sure I understand to the fullest extent what you mean by cleansing reactions, because the Youtube videos I've been watching on Buteyko hasn't mentioned anything about it. I did, however, notice my sleep was worse for the first couple weeks I did it. I'm still very much in the process of determining whether this practice will work for me or not, but so far the side effects have been mostly positive.

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              • DulkadirD
                Dulkadir
                last edited by

                that means it's working. ur body is detoxing, you just have to wait 40 years for the amazing effects to show themselves

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                • AmazoniacA
                  Amazoniac
                  last edited by

                  Poison A exorcism affects the synthesis of ascourgic acid (rats) and it reflects on the adrenals. But Grant speculates that ascourgic acid isn't needed as well. So, for animals to lower poison A and ascourgic acid at once is helpful, it means room for useful molecules.

                  From an earlier discussion..


                  Vitamin A: Not Required for Adrenal Steroidogenesis in Rats

                  "It has been shown (8) that there is an immediate decrease (up to 50 percent) in ascorbate synthesis which accompanies any significant depletion of liver vitamin A."

                  "The purpose of this was to demonstrate that functional and morphological changes occur in steroidogenic organs before any manifestations of peripheral vitamin A deficiency occur."

                  eb121cef-d1ad-4f12-839d-c8e43b010c3d-image.png

                  "Vitamin A-depleted rats maintained on a diet free of ascorbate had a decrease in the activity of adrenal 3β-hydroxysteroid dehydrogenase, and extensive adrenocortical degeneration. The use of an ascorbate supplement prevented the symptoms."

                  • Asteroidogenesis | Wikipedia

                  d85fea5e-142f-4f63-bdf3-8888f0a97704-image.png

                  486efb1c-02f8-4bcc-97ac-04d56d163bcc-image.png

                  "The morphological appearance of the gland from an animal supplemented with vitamin C and deficient in vitamin A (Fig. 1D) was indistinguishable from that of the control group (Fig. 1A)."

                  "Similar hyperplasia and tissue destruction found in rabbits and guinea pigs on a scorbutic diet (23) were indistinguishable from that produced by prolonged stimulation of adrenocorticotrophic hormone (ACTH) in stress (24). Selye and Stone suggested that this syndrome was caused by extensive demands on the adrenal cortex as a result of long-term or overstimulation by ACTH (25). Staining for adrenal cholesterol showed undetectable amounts in group 2 (Fig. 1G), implying that less than 3 to 6 percent 7-hydroxycholesterol was present (26); the group deficient in vitamin A but with vitamin C replaced (Fig. 1H) and the control (Fig. 1F) group showed varied degrees of staining, an indication that 12 to 25 percent hydroxycholesterol and 40 to 50 percent total lipids were present. ACTH lowers adrenal cholesterol, and depletion occurs in long-term stimulation (27). Also, the decrease in adrenal cholesterol in scurvy is attributed to diminished acetylation in the body (28) with decreased acetate uptake and utilization by the adrenal (29). Vitamin A is nonessential for cholesterol biosynthesis (2, 30)."

                  I now have a support page!

                  MauritioM 1 Reply Last reply Reply Quote 0
                  • MauritioM
                    Mauritio @Amazoniac
                    last edited by Mauritio

                    @Amazoniac
                    It is very interesting that Vitamin C ameliorates some of the issues of a Vitamin A deficiency, which implies that Vit. A deficiency causes oxidative stress in some way, which Vitamin C reverses. This hypothesis would be further validated if there were studies showing that other anti-oxidants like selenium or Vitamin E can do the same thing.

                    Table 2 however shows that while Vitamin C restored 3bHSD and thus androstenedione concenctation,the Vitamin A deficient and VItamin C supplemented group 3, had a cortisol blood level that was more than 50% higher than group 1, which received Vitamin A. So the addition of Vitamin C seems to restore the steroid production, but move them more into a stress hormones state.

                    With that beeing said , it would be good to see how other hormones like pregnenolone, testosterone or prolactin change on those diets.

                    Dare to think.

                    My X:
                    x.com/Metabolicmonstr

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                    • P
                      Peatly
                      last edited by

                      UV Radiation Induces Vitamin A Deficiency in Skin

                      A successful depopulation agenda requires high excess death rates, lower birth rates and for the majority to vilify those that question it.

                      MauritioM 1 Reply Last reply Reply Quote 0
                      • MauritioM
                        Mauritio @Peatly
                        last edited by

                        @Peatly said in Mild Vitamin A deficiency decreases DHEA and Pregnenolone by 40%:

                        UV Radiation Induces Vitamin A Deficiency in Skin

                        Peat has a very old newsletter where he says that UV rays cause a film of free radicals on hair (and skin) that can persist for a few hours ,even after leaving the sun. Just a few seconds of red light will neutralize the free radicals.

                        Dare to think.

                        My X:
                        x.com/Metabolicmonstr

                        P 1 Reply Last reply Reply Quote 0
                        • P
                          Peatly @Mauritio
                          last edited by Peatly

                          @Mauritio Thank you.

                          I just found this quote from the mega master newsletter

                          "Recently, the polyunsaturated oils have been identified as the main thing in cells that radiation interacts with, to cause cellular damage. Vitamin E, taken internally or even applied to the skin, has been found to reduce the damage produced by exposure to ultraviolet radiation, which is logical, since it interrupts the chain reactions of toxic free-radicals produced when unsaturated oils are oxidized by radiation or other injury. Aspirin has been found to have a similar effect in reducing the harmful effects which develop in the skin after sunlight overexposure. Coconut oil has been used for generations in “ suntan lotions, ” and whether it is absorbed through the skin or eaten as a food, it clearly has a protective antioxidant function. Carotene seems to work with vitamin E in the skin to reduce injury by ultraviolet radiation. Caffeine also has shown a protective action against radiation, but its mechanism of action isnʼt clearly understood." Townsend Letter for Doctors & Patients, June 1996, Page 83 – 85

                          Dr. Peat also said he stopped burning in the sun after supplementing vitamin D, getting lots of milk and limiting PUFA.

                          A successful depopulation agenda requires high excess death rates, lower birth rates and for the majority to vilify those that question it.

                          MauritioM 1 Reply Last reply Reply Quote 0
                          • MauritioM
                            Mauritio @Peatly
                            last edited by

                            @Peatly said in Mild Vitamin A deficiency decreases DHEA and Pregnenolone by 40%:

                            @Mauritio Thank you.

                            I just found this quote from the mega master newsletter

                            "Recently, the polyunsaturated oils have been identified as the main thing in cells that radiation interacts with, to cause cellular damage. Vitamin E, taken internally or even applied to the skin, has been found to reduce the damage produced by exposure to ultraviolet radiation, which is logical, since it interrupts the chain reactions of toxic free-radicals produced when unsaturated oils are oxidized by radiation or other injury. Aspirin has been found to have a similar effect in reducing the harmful effects which develop in the skin after sunlight overexposure. Coconut oil has been used for generations in “ suntan lotions, ” and whether it is absorbed through the skin or eaten as a food, it clearly has a protective antioxidant function. Carotene seems to work with vitamin E in the skin to reduce injury by ultraviolet radiation. Caffeine also has shown a protective action against radiation, but its mechanism of action isnʼt clearly understood." Townsend Letter for Doctors & Patients, June 1996, Page 83 – 85

                            Dr. Peat also said he stopped burning in the sun after supplementing vitamin D, getting lots of milk and limiting PUFA.

                            Good one.

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

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