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Lisuride

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  • L
    Lothric
    last edited by Jul 25, 2024, 2:07 AM

    I have been trying Lisuride recently and it has been one of the most noticeable and beneficial things from IdeaLabs I have tried yet. It has substantially changed my mood, flow, drive, motivation. A real noticeable change. My wife even commented on how just upbeat I’ve been lately. Very unstressed and can handle stressful situations much much easier.

    With that being said is anyone aware of the downside of taking this for extended timeframes? Could it lead to dopamine down regulation? I’m imagining I already had low dopamine based on the beneficial this has been for me. But could it exasperate the issue and cause a dependence?

    B 1 Reply Last reply Jul 26, 2024, 7:06 PM Reply Quote 0
    • P
      PrinceTrebata
      last edited by Jul 26, 2024, 12:04 AM

      I don't think it could lead to long-term desensitization. Agonizing a dopamine receptor shouldn't be any different from agonizing a serotonin or androgen receptor. The biggest problem is the effects might not be as pronounced with continuous use, so you may need to cycle to continue feeling its effects. With Lisuride as well, I heard it's very potent and the effect is very noticeable, but it only lasts a little while in comparison to something like bromocriptine.

      1 Reply Last reply Reply Quote 0
      • B
        BeamsOfEnergy @Lothric
        last edited by Jul 26, 2024, 7:06 PM

        @Lothric do you use it topically or orally? What is your dose? Thanks

        L 1 Reply Last reply Jul 27, 2024, 12:03 AM Reply Quote 0
        • L
          Lothric @BeamsOfEnergy
          last edited by Jul 27, 2024, 12:03 AM

          @BeamsOfEnergy I’ve used it both. Usually I use topically on my wrists. Take 5-8 drops. Although the first time I only tried two. As others have said it seems to become less potent after extended uses so I’m going to cycle it

          1 Reply Last reply Reply Quote 0
          • J
            JulofEnoch
            last edited by Jul 28, 2024, 6:49 PM

            How long have you been taking lisuride?

            Greift nur hinein ins volle Menschenleben! Ein jeder lebt's, nicht vielen ist's bekannt, und wo ihr's packt, da ist's interessant.

            Ray Peat first-ever interview(July 1987 on UofO Student Radio)

            L 1 Reply Last reply Jul 28, 2024, 10:06 PM Reply Quote 0
            • L
              Lothric @JulofEnoch
              last edited by Jul 28, 2024, 10:06 PM

              @JulofEnoch I took it for a week. Effects started to get less pronounced so I’m cycling off this week. Going to try it again after this week.

              R 1 Reply Last reply Aug 9, 2024, 8:20 AM Reply Quote 0
              • R
                RandomUser @Lothric
                last edited by Aug 9, 2024, 8:20 AM

                @Lothric

                Are you back on Lisuride?

                L 1 Reply Last reply Aug 10, 2024, 1:08 AM Reply Quote 0
                • L
                  Lothric @RandomUser
                  last edited by Lothric Aug 10, 2024, 1:08 AM Aug 10, 2024, 1:08 AM

                  @RandomUser I take it periodically maybe once or twice. Effects are less noticeable but I’ve also been in an elevated mood ever since the first dose. I have read on the Peat forum that it is like LSD in the sense that it can shift your mindset for a long time so it might just be useful as a “as needed” tool. It does lower prolactin so I generally dose it after intimate time with my wife

                  O 1 Reply Last reply Mar 11, 2025, 9:28 PM Reply Quote 0
                  • O
                    of @Lothric
                    last edited by Mar 11, 2025, 9:28 PM

                    @Lothric I think they're wrong

                    1 Reply Last reply Reply Quote 0
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