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    Isoleucine restriction in mice increases metabolic rate and lifespan

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    • serotoninskepticS
      serotoninskeptic
      last edited by

      Scientists restricted one amino acid (isoleucine) in mice. This made them eat twice as much, have ~75% less fat mass, and live 33% longer.

      https://www.cell.com/cell-metabolism/abstract/S1550-4131(23)00374-1?ref=dailydevbytes.com

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      • L
        LetTheRedeemed
        last edited by

        interesting.

        googled this:
        "Isoleucine and valine inhibited the absorption of leucine, and leucine inhibited the absorption of isoleucine and valine."
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265085/#:~:text=Isoleucine and valine inhibited the,of the interfering amino acid.

        InsomniacI 1 Reply Last reply Reply Quote 0
        • InsomniacI
          Insomniac @LetTheRedeemed
          last edited by

          @LetTheRedeemed said in Isoleucine restriction in mice increases metabolic rate and lifespan:

          interesting.

          googled this:
          "Isoleucine and valine inhibited the absorption of leucine, and leucine inhibited the absorption of isoleucine and valine."
          https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265085/#:~:text=Isoleucine and valine inhibited the,of the interfering amino acid.

          That's a really good find.

          @Serotoninskeptic Thanks for posting. It's a shame sci-hub doesn't have the paper yet.

          serotoninskepticS L 2 Replies Last reply Reply Quote 0
          • serotoninskepticS
            serotoninskeptic @Insomniac
            last edited by

            @Insomniac Yes and gelatin just so happens to be deficient in isoleucine as well

            InsomniacI 1 Reply Last reply Reply Quote 0
            • L
              LetTheRedeemed @Insomniac
              last edited by

              @Insomniac 🙏

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              • InsomniacI
                Insomniac @serotoninskeptic
                last edited by Insomniac

                This post is deleted!
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