Niclosamide reduces serotonin and glutamate
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Niclosamide a pro-metabolic drug that deserves more attention IMO.
It's an uncoupler, TLR4 antagonist , anti-fungal, Anti-viral, neuroprotective ,helps diabetes and fatty liver .. you name it. It shares structural similarity to aspirin as well.
I'm going to link the thread where we discussed our experiences with it on the former RPF:
https://lowtoxinforum.com/threads/niclosamide-for-fat-loss-uncoupling.42781/This study shows that it lowers serotonin and glutamate in physhological doses.
Maybe that's why some people reported better sleep and mood on it.
It should be helpful for people with excessive itching, as in seasonal allergies ."Additionally, the levels of mGluR1, mGluR5, 5-HT2, and TRPV1 were significantly reduced."
It might also have anti-fibrotic effects since it antagonizes the 5HT2 receptor.
Dare to think.
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Just another reminder, every time you guys link to that imposter forum, it makes it stronger and more present for G00gle.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
This format would be better. A step beyond that would be not to mention its name at all and have an abbreviation perhaps. Such as:
LTF DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
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@bio3nergetic said in Niclosamide reduces serotonin and glutamate:
Just another reminder, every time you guys link to that imposter forum, it makes it stronger and more present for G00gle.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
This format would be better. A step beyond that would be not to mention its name at all and have an abbreviation perhaps. Such as:
LTF DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
Calm down. It's still a good place as an archive . So the value of it as an archive is higher than trying to avoid it any cost so it has a tiny amount less traffic. My 2 cents.
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@Mauritio wow impressive one thanks. how are you taking it & what do you notice, if you still do? so far im thinking day on day off, after bowel movement, maybe pm use, 25mg-50mg, or to have handy for a serotonin state occasionally
thats a big effect on serotonin induced itching (could be very useful for lightening the effects of mast cell activation syndrome , as thats not just histamine mediated its through serotonin and others too via the TRPv trpa receptors). thats the best effect ive seen for this
an upside of only needing a small amount of a normal tablet assuming cant get powder, u get a lot less of all the shite its mixed with
it decreases the clearance of some compounds through inhibiting some kidney transporters, something to be aware of (& maybe day on day off is best)
https://www.sciencedirect.com/science/article/abs/pii/S0009279724000322
another reason should be good for cystic fibrosis, (on top of the anti fibrotic effect u mentioned) lowers the mucus secretion toward controls https://pmc.ncbi.nlm.nih.gov/articles/PMC10794189/#Sec2
and showing the anti fibrosis effect (reversed fibrosis / ED in penis of diabetic rats) https://academic.oup.com/jsm/article-abstract/21/12/1111/7822244?redirectedFrom=fulltext
"Both functional and molecular alterations in DMED were effectively reversed by Nic-treated diabetic rats without a glycemic alteration. Nic could be a promising candidate for the treatment of DMED due to its antifibrotic effects."https://aacrjournals.org/cancerres/article/71/12/4172/567782/Antihelminth-Compound-Niclosamide-Downregulates
showed a good slowing effect but not massive on fast growing tumor, but for a slow growing tumor it stopped growth for a while
(i guess tolerance built using 6 days a week for 18 days? controls surged then too so maybe not tolerance & less effective at end stage)
"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
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@bio3nergetic said in Niclosamide reduces serotonin and glutamate:
Just another reminder, every time you guys link to that imposter forum, it makes it stronger and more present for G00gle.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
This format would be better. A step beyond that would be not to mention its name at all and have an abbreviation perhaps. Such as:
LTF DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
I'm not an SEO expert, but doesn't only the first link from a website count for google? So 100,000 links from one website is as good as one?
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@Mauritio calm down? I'm afraid if I get any calmer I won't have a pulse. It's just a reminder, like I said. Do what you like.
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@Luke I know a bit about SEO, and believe it, the more links the more "popularity" signaling to g$$gle
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@cs3000 said in Niclosamide reduces serotonin and glutamate:
wow impressive one thanks. how are you taking it & what do you notice, if you still do? so far im thinking day on day off, after bowel movement, maybe pm use, 25mg-50mg, or to have handy for a serotonin state occasionally
No I stopped taking it 3 years ago due to constipation.
It reduced my necessary sleeping time and in the beginning it made my mood very good.
But both me and the women taking it in the thread above didn't continue to see the same benefits so there might be a good case for cycling it.
I think i took 100mg most of the time.Didn't you write something about cancer and pH? Niclosamide seems to affect that :
https://pubmed.ncbi.nlm.nih.gov/22474287/ -
This study also shows an anti-fibrotic effect. Not only that the anti-fibrotic effect was medicated via mTOR inhibition, which has its own host of benefits. So it seems like niclosamide might even qualify as an anti-,aging drug or something that is taken in frequently for its vast range of benefits like aspirin :
"Furthermore, NEN-activated noncanonical autophagy resensitized fibroblasts to apoptosis. The above findings demonstrated the potential antifibrotic effect of NEN mediated via modulation of the PI3K-mTORC1 and autophagy pathways. "
https://pubmed.ncbi.nlm.nih.gov/35159160/
Helps with calcification in vitro . Also via mTOR inhibition.
https://pubmed.ncbi.nlm.nih.gov/39515588/ -
What do you think of this one ? There's a few studies showing androgen receptor inhibition.
Although I don't remember any problems on that front. But surely something to keep in mind .
@cs3000
https://pubmed.ncbi.nlm.nih.gov/27049719/Dare to think.
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It might also be helpful for autism .
They cite a different mechanism but it's helpfulness is not surprising it lowers glutamate and serotonin. -
@Mauritio its mostly inhibiting just the variant there (not normal androgen receptors) splice variants lack parts that de-activate them so continually active https://www.nature.com/articles/nrurol.2015.13
ironically depleting androgens in prostate cancer can induce more of them (and more significant amounts in the extracted cells part but idk how much they contribute)
https://aacrjournals.org/clincancerres/article/20/6/1590/211454/Rapid-Induction-of-Androgen-Receptor-SpliceAR-FL (normal receptors) arent getting inhibited much but AR- variants gone
|1 found mild estrogenic activity in vitro in cancered cell lines which doesnt match with the in vivo anti tumor activity,
but mainly on ERRy and ERRa estrogen related receptor, 30% max transcriptional activity of estradiol on estrogen receptors, (maybe displacing estrogens for milder effect lower transcription? but potent on ERRs in these cells)
,https://www.sciencedirect.com/science/article/abs/pii/S0300483X21001281
They found some hormone reducing effects in fish but idk how relevant to mammals
In adrenocortical cancer cells it reduced hormones production at nM concentration,
https://academic.oup.com/jcem/article/103/10/3706/5056322
- It has a mutagenic effect at higher end dose
humans show lymphocyte abnormalities from treatment at higher end dose. apparently its lethal in 100% of some strains of mice injected at low dose 7.5mg/kg. needs to be transformed in the gastrointestinal tract first & go through the liver https://pubmed.ncbi.nlm.nih.gov/3278217/
orally 60mg/kg ~300mg-400mg human dose starts to give a rise in abnormal sperm
its a mild effect there but thats only with 5 consecutive daysin humans the mutagenic effects on lymphocytes with 1g-2g for a day then 6 days of 500mg increased. (i'd guess red blood cells might be more vulnerable) doi: 10.1016/0165-7992(86)90015-1)
so to be on the safer side i wouldn't take >100mg of this regularly, 25mg has effects. and maybe good to have a few days off a week just incase.
@Mauritio said in Niclosamide reduces serotonin and glutamate:
Didn't you write something about cancer and pH? Niclosamide seems to affect that :
https://pubmed.ncbi.nlm.nih.gov/22474287/cool thanks , yeah lowering pH to a certain level helps make the apoptosis process more effective
"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
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@cs3000 ok thanks !
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@bio3nergetic if you look at the traffic it's all but dead anyway, let the pain go young warrior.
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@cs3000 said in Niclosamide reduces serotonin and glutamate:
and showing the anti fibrosis effect (reversed fibrosis / ED in penis of diabetic rats) https://academic.oup.com/jsm/article-abstract/21/12/1111/7822244?redirectedFrom=fulltext
"Both functional and molecular alterations in DMED were effectively reversed by Nic-treated diabetic rats without a glycemic alteration. Nic could be a promising candidate for the treatment of DMED due to its antifibrotic effects."The antifibrotic effect can be expected with ANY drug or substance antagonizing serotonin receptors. This has been well-established, even acknowledged by conventional medicine, though perhaps not as widely as we might hope. It has been known for at least 50 years that children suffering from cystic fibrosis, fibrosis, or liver disorders have significantly higher serotonin levels in their blood and central nervous system, coupled with a deficiency in monoamine oxidase A. The promotion of fibrosis is characteristic of 5-HT2A and 5-HT2B, and their hyperactivation leads to the expression of fibrosis-related genes.
In this study (https://www.sciencedirect.com/science/article/abs/pii/S2405457721000292), the effect of cyproheptadine on appetite in children with cystic fibrosis was evaluated, which unsurprisingly resulted in an increase in BMI. However, the researchers also noted a "mild improvement" in lung function, which they attributed to improved nutrition rather than to cyproheptadine's serotoninolytic action—something I believe is a misinterpretation.
I would recommend that anyone dealing with fibrosis-related issues adopt a diet that supports proper central serotonin regulation. I don’t believe that medication is always necessary in every case, although it can be a valuable tool. Serotonin is merely a signaling molecule, and regardless of how one views it, its canonical harmfulness is directly linked to its excessive signaling.
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Took 50mg niclosamide today . Resulted in strong fatigue and low energy. Hypoglycemia and hunger increases as well.
Probably better to take in the evening.Edit: i ate an insane amount of food yesterday and still woke up weighing exactly the same as the day before .
I also slept very well and feel refreshed. Maybe taking it in the last part of the day is more sustainable. The malaise I felt yesterday might also be some sort of microbial die off.Dare to think.
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@Mauritio said in Niclosamide reduces serotonin and glutamate:
Took 50mg niclosamide today . Resulted on strong fatigue and low energy. Hypoglycemia and hunger increase as well.
Probably better in the evening.Do you take thiamine? I recommend taking it, as niclosamide can uniquely activate AMPK and disrupt the proton gradient. Higher glucose intake will likely have a compensatory effect, but it does not guarantee that the redox balance will return to normal levels.
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@war4512 said in Niclosamide reduces serotonin and glutamate:
@Mauritio said in Niclosamide reduces serotonin and glutamate:
Took 50mg niclosamide today . Resulted on strong fatigue and low energy. Hypoglycemia and hunger increase as well.
Probably better in the evening.Do you take thiamine? I recommend taking it, as niclosamide can uniquely activate AMPK and disrupt the proton gradient. Higher glucose intake will likely have a compensatory effect, but it does not guarantee that the redox balance will return to normal levels.
I only take whatever is in a few drops ofEnergin.
l noticed thatmy Buteyko Pause increased significantly,meaning I could hold my breath longer. It seems to increaseCO2 not sure if via uncoupling or another mechanism. I suspect it might be a carbonic anhydrase inhibitor similarly to acetozolamide and Aspirin.next time ill probably try a snaller dose to avoid hypoglycemia.
