Niclosamide reduces serotonin and glutamate
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Niclosamide a pro-metabolic drug that deserves more attention IMO.
It's an uncoupler, TLR4 antagonist , anti-fungal, Anti-viral, neuroprotective ,helps diabetes and fatty liver .. you name it. It shares structural similarity to aspirin as well.
I'm going to link the thread where we discussed our experiences with it on the former RPF:
https://lowtoxinforum.com/threads/niclosamide-for-fat-loss-uncoupling.42781/This study shows that it lowers serotonin and glutamate in physhological doses.
Maybe that's why some people reported better sleep and mood on it.
It should be helpful for people with excessive itching, as in seasonal allergies ."Additionally, the levels of mGluR1, mGluR5, 5-HT2, and TRPV1 were significantly reduced."
It might also have anti-fibrotic effects since it antagonizes the 5HT2 receptor.
Dare to think.
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Just another reminder, every time you guys link to that imposter forum, it makes it stronger and more present for G00gle.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
This format would be better. A step beyond that would be not to mention its name at all and have an abbreviation perhaps. Such as:
LTF DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
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@bio3nergetic said in Niclosamide reduces serotonin and glutamate:
Just another reminder, every time you guys link to that imposter forum, it makes it stronger and more present for G00gle.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
This format would be better. A step beyond that would be not to mention its name at all and have an abbreviation perhaps. Such as:
LTF DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
Calm down. It's still a good place as an archive . So the value of it as an archive is higher than trying to avoid it any cost so it has a tiny amount less traffic. My 2 cents.
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@Mauritio wow impressive one thanks. how are you taking it & what do you notice, if you still do? so far im thinking day on day off, after bowel movement, maybe pm use, 25mg-50mg, or to have handy for a serotonin state occasionally
thats a big effect on serotonin induced itching (could be very useful for lightening the effects of mast cell activation syndrome , as thats not just histamine mediated its through serotonin and others too via the TRPv trpa receptors). thats the best effect ive seen for this
an upside of only needing a small amount of a normal tablet assuming cant get powder, u get a lot less of all the shite its mixed with
it decreases the clearance of some compounds through inhibiting some kidney transporters, something to be aware of (& maybe day on day off is best)
https://www.sciencedirect.com/science/article/abs/pii/S0009279724000322
another reason should be good for cystic fibrosis, (on top of the anti fibrotic effect u mentioned) lowers the mucus secretion toward controls https://pmc.ncbi.nlm.nih.gov/articles/PMC10794189/#Sec2
and showing the anti fibrosis effect (reversed fibrosis / ED in penis of diabetic rats) https://academic.oup.com/jsm/article-abstract/21/12/1111/7822244?redirectedFrom=fulltext
"Both functional and molecular alterations in DMED were effectively reversed by Nic-treated diabetic rats without a glycemic alteration. Nic could be a promising candidate for the treatment of DMED due to its antifibrotic effects."https://aacrjournals.org/cancerres/article/71/12/4172/567782/Antihelminth-Compound-Niclosamide-Downregulates
showed a good slowing effect but not massive on fast growing tumor, but for a slow growing tumor it stopped growth for a while
(i guess tolerance built using 6 days a week for 18 days? controls surged then too so maybe not tolerance & less effective at end stage)
"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
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@bio3nergetic said in Niclosamide reduces serotonin and glutamate:
Just another reminder, every time you guys link to that imposter forum, it makes it stronger and more present for G00gle.
lowtoxinforum DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
This format would be better. A step beyond that would be not to mention its name at all and have an abbreviation perhaps. Such as:
LTF DOT com/threads/niclosamide-for-fat-loss-uncoupling.42781
I'm not an SEO expert, but doesn't only the first link from a website count for google? So 100,000 links from one website is as good as one?
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@Mauritio calm down? I'm afraid if I get any calmer I won't have a pulse. It's just a reminder, like I said. Do what you like.
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@Luke I know a bit about SEO, and believe it, the more links the more "popularity" signaling to g$$gle
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@cs3000 said in Niclosamide reduces serotonin and glutamate:
wow impressive one thanks. how are you taking it & what do you notice, if you still do? so far im thinking day on day off, after bowel movement, maybe pm use, 25mg-50mg, or to have handy for a serotonin state occasionally
No I stopped taking it 3 years ago due to constipation.
It reduced my necessary sleeping time and in the beginning it made my mood very good.
But both me and the women taking it in the thread above didn't continue to see the same benefits so there might be a good case for cycling it.
I think i took 100mg most of the time.Didn't you write something about cancer and pH? Niclosamide seems to affect that :
https://pubmed.ncbi.nlm.nih.gov/22474287/ -
This study also shows an anti-fibrotic effect. Not only that the anti-fibrotic effect was medicated via mTOR inhibition, which has its own host of benefits. So it seems like niclosamide might even qualify as an anti-,aging drug or something that is taken in frequently for its vast range of benefits like aspirin :
"Furthermore, NEN-activated noncanonical autophagy resensitized fibroblasts to apoptosis. The above findings demonstrated the potential antifibrotic effect of NEN mediated via modulation of the PI3K-mTORC1 and autophagy pathways. "
https://pubmed.ncbi.nlm.nih.gov/35159160/
Helps with calcification in vitro . Also via mTOR inhibition.
https://pubmed.ncbi.nlm.nih.gov/39515588/ -
What do you think of this one ? There's a few studies showing androgen receptor inhibition.
Although I don't remember any problems on that front. But surely something to keep in mind .
@cs3000
https://pubmed.ncbi.nlm.nih.gov/27049719/ -
It might also be helpful for autism .
They cite a different mechanism but it's helpfulness is not surprising it lowers glutamate and serotonin.
